Serotonin
Ligand Summary
Name: Serotonin
PubChem: 5202
PubChem: 160436
Guide to Pharmacology: 5
ChEMBL: CHEMBL39
ChEMBL: CHEMBL535832
LyCHI: MNAP8MWU6R2P
Target Activities
HTR1A
5-hydroxytryptamine receptor 1A
48 Activities
Items per page:
1 – 10 of 48
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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EC50 | 9.3 | J. Med. Chem., (2006) 49:1:125 | ||||
Ki | 9.21 | Bioorg. Med. Chem., (2012) 20:15:4862 | ||||
EC50 | 9.15 | Bioorg. Med. Chem. Lett., (2006) 16:8:2101 | ||||
Ki | 9.05 | Bioorg. Med. Chem., (2013) 21:4:856 | ||||
Ki | 9.04 | Bioorg Med Chem Lett, (2016) 26:16:4052 | ||||
EC50 | 9 | J. Med. Chem., (2006) 49:1:125 | ||||
Ki | 8.96 | MedChemComm, (2017) 8:8:1690 | ||||
IC50 | 8.92 | J. Med. Chem., (2003) 46:19:4188 | ||||
Ki | 8.92 | Bioorg Med Chem, (2019) 27:18:4163 | ||||
Ki | 8.9 | J. Med. Chem., (2008) 51:10:2887 | ||||
HTR2C
5-hydroxytryptamine receptor 2C
35 Activities
Items per page:
1 – 10 of 35
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
EC50 | 10.05 | J. Med. Chem., (2009) 52:7:1885 | ||||
EC50 | 10.05 | ACS Med. Chem. Lett., (2011) 2:12:929 | ||||
EC50 | 9.77 | J Med Chem, (2017) 60:14:6273 | ||||
EC50 | 9.74 | J Med Chem, (2017) 60:14:6273 | ||||
EC50 | 9.72 | Eur J Med Chem, (2019) 182:None:111626 | ||||
EC50 | 9.72 | Eur J Med Chem, (2019) 182:None:111626 | ||||
EC50 | 9.68 | J. Med. Chem., (2015) 58:4:1992 | ||||
EC50 | 9.46 | Bioorg. Med. Chem. Lett., (2013) 23:11:3411 | ||||
EC50 | 9.4 | Bioorg. Med. Chem. Lett., (2013) 23:11:3411 | ||||
EC50 | 9.39 | J Med Chem, (2020) 63:9:4579 | ||||
HTR7
5-hydroxytryptamine receptor 7
33 Activities
Items per page:
1 – 10 of 33
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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8.3 | ||||||
Ki | 9.96 | Eur. J. Med. Chem., (2013) 63:None:85 | ||||
Ki | 9.89 | J. Med. Chem., (2011) 54:15:5320 | ||||
Ki | 9.77 | J Med Chem, (2017) 60:1:349 | ||||
Ki | 9.66 | J. Med. Chem., (2008) 51:22:7094 | ||||
IC50 | 9.6 | Bioorg. Med. Chem., (2016) 24:8:1793 | ||||
IC50 | 9.6 | Bioorg Med Chem, (2017) 25:2:471 | ||||
IC50 | 9.54 | Eur. J. Med. Chem., (2013) 63:None:85 | ||||
IC50 | 9.33 | J Med Chem, (2017) 60:1:349 | ||||
IC50 | 9.31 | Bioorg. Med. Chem., (2013) 21:10:2764 | ||||
HTR2A
5-hydroxytryptamine receptor 2A
28 Activities
Items per page:
1 – 10 of 28
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
- | 8.9 | |||||
EC50 | 9.57 | Eur J Med Chem, (2019) 182:None:111626 | ||||
EC50 | 9.56 | Eur J Med Chem, (2019) 182:None:111626 | ||||
EC50 | 9.29 | J Nat Prod, (2020) 83:2:461 | ||||
EC50 | 9.29 | J Nat Prod, (2020) 83:2:461 | ||||
EC50 | 8.82 | Bioorg. Med. Chem. Lett., (2013) 23:11:3411 | ||||
EC50 | 8.81 | Bioorg. Med. Chem. Lett., (2013) 23:11:3411 | ||||
EC50 | 8.8 | J Med Chem, (2018) 61:22:10017 | ||||
EC50 | 8.73 | J. Med. Chem., (2015) 58:4:1992 | ||||
EC50 | 8.63 | J Med Chem, (2017) 60:14:6273 | ||||
HTR2B
5-hydroxytryptamine receptor 2B
22 Activities
Items per page:
1 – 10 of 22
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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8 | ||||||
EC50 | 9.3 | J. Med. Chem., (2009) 52:7:1885 | ||||
EC50 | 9.07 | ACS Med. Chem. Lett., (2011) 2:12:929 | ||||
EC50 | 9.07 | Eur J Med Chem, (2019) 182:None:111626 | ||||
EC50 | 9.07 | Eur J Med Chem, (2019) 182:None:111626 | ||||
EC50 | 9.04 | J. Med. Chem., (2015) 58:4:1992 | ||||
EC50 | 8.97 | Bioorg. Med. Chem. Lett., (2013) 23:11:3411 | ||||
EC50 | 8.96 | Bioorg. Med. Chem. Lett., (2013) 23:11:3411 | ||||
EC50 | 8.84 | J Med Chem, (2017) 60:14:6273 | ||||
EC50 | 8.84 | J Med Chem, (2017) 60:14:6273 | ||||
HTR1B
5-hydroxytryptamine receptor 1B
20 Activities
Items per page:
1 – 10 of 20
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
- | 8.1 | |||||
Ki | 8.96 | J. Med. Chem., (2008) 51:12:3609 | ||||
Ki | 8.4 | J. Med. Chem., (1996) 39:1:314 | ||||
Ki | 8.4 | J. Med. Chem., (1994) 37:18:2828 | ||||
Ki | 8.4 | Eur. J. Med. Chem., (2013) 63:None:85 | ||||
EC50 | 8.33 | Bioorg. Med. Chem. Lett., (1998) 8:11:1407 | ||||
Ki | 8.32 | J. Med. Chem., (2003) 46:2:265 | ||||
EC50 | 8.32 | J. Med. Chem., (1996) 39:25:4920 | ||||
Ki | 8.3 | J. Med. Chem., (2003) 46:24:5117 | ||||
IC50 | 8.3 | J. Med. Chem., (1992) 35:23:4503 | ||||
HTR6
5-hydroxytryptamine receptor 6
16 Activities
Items per page:
1 – 10 of 16
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
- | 7.9 | |||||
IC50 | 7.56 | J. Med. Chem., (2010) 53:6:2521 | ||||
Ki | 7.48 | J. Med. Chem., (2014) 57:11:4543 | ||||
Ki | 7.48 | Eur. J. Med. Chem., (2015) 92:None:221 | ||||
EC50 | 7.36 | J Med Chem, (2018) 61:22:10017 | ||||
Ki | 7.3 | Eur. J. Med. Chem., (2013) 63:None:85 | ||||
Ki | 7.21 | J Med Chem, (2017) 60:1:349 | ||||
Ki | 7.19 | J. Med. Chem., (2003) 46:14:2795 | ||||
Ki | 7.16 | Med Chem Res, (2005) 14:1:1 | ||||
Ki | 7.12 | J. Med. Chem., (2000) 43:5:1011 | ||||
HTR1D
5-hydroxytryptamine receptor 1D
10 Activities
Items per page:
1 – 10 of 10
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 9.3 | J. Med. Chem., (2008) 51:12:3609 | ||||
Ki | 8.77 | J. Med. Chem., (1996) 39:1:314 | ||||
Ki | 8.7 | J. Med. Chem., (1999) 42:3:526 | ||||
IC50 | 8.52 | J. Med. Chem., (1990) 33:8:2087 | ||||
IC50 | 8.52 | Bioorg. Med. Chem. Lett., (1995) 5:20:2391 | ||||
Ki | 8.52 | J. Med. Chem., (1990) 33:2:755 | ||||
Ki | 8.32 | J. Med. Chem., (1995) 38:18:3602 | ||||
Ki | 8.3 | Bioorg. Med. Chem. Lett., (1998) 8:11:1407 | ||||
Ki | 8.3 | J. Med. Chem., (1996) 39:25:4920 | ||||
Ki | 8.26 | J. Med. Chem., (1994) 37:18:2828 | ||||
HTR4
5-hydroxytryptamine receptor 4
5 Activities
Items per page:
1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
- | 7.7 | |||||
7.2 | ||||||
EC50 | 7.92 | J. Med. Chem., (2009) 52:8:2214 | ||||
Ki | 7.53 | Eur. J. Med. Chem., (2009) 44:7:2952 | ||||
EC50 | 7 | Nature, (2007) 450:7169:553 | ||||
HTR3A
5-hydroxytryptamine receptor 3A
4 Activities
Items per page:
1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
EC50 | 6.85 | Bioorg. Med. Chem. Lett., (2011) 21:1:58 | ||||
EC50 | 6.75 | Bioorg. Med. Chem. Lett., (2011) 21:1:58 | ||||
EC50 | 6.34 | J. Med. Chem., (2007) 50:19:4616 | ||||
EC50 | 6.3 | J. Med. Chem., (2007) 50:19:4616 | ||||
HTR1F
5-hydroxytryptamine receptor 1F
3 Activities
HTR5A
5-hydroxytryptamine receptor 5A
3 Activities
HTR1E
5-hydroxytryptamine receptor 1E
3 Activities
DRD1
D(1A) dopamine receptor
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
- | 5 | |||||
DRD5
D(1B) dopamine receptor
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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5.5 | ||||||
SLC36A1
Proton-coupled amino acid transporter 1
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 2.2 | |||||