Pharos : Ligand Details

Target Activities

Explore Associated and Predicted Targets

HTR1A

Tclin

5-hydroxytryptamine receptor 1A

48 Activities

Items per page:

1 – 10 of 48

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
EC50	9.3	J. Med. Chem., (2006) 49:1:125	16392798

Ki	9.21	Bioorg. Med. Chem., (2012) 20:15:4862	22748706

EC50	9.15	Bioorg. Med. Chem. Lett., (2006) 16:8:2101	16458504

Ki	9.05	Bioorg. Med. Chem., (2013) 21:4:856	23332346

Ki	9.04	Bioorg Med Chem Lett, (2016) 26:16:4052	27396505

EC50	9	J. Med. Chem., (2006) 49:1:125	16392798

Ki	8.96	MedChemComm, (2017) 8:8:1690

IC50	8.92	J. Med. Chem., (2003) 46:19:4188	12954071

Ki	8.92	Bioorg Med Chem, (2019) 27:18:4163	31383628

Ki	8.9	J. Med. Chem., (2008) 51:10:2887	18433113

HTR2C

Tclin

5-hydroxytryptamine receptor 2C

35 Activities

Items per page:

1 – 10 of 35

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
EC50	10.05	J. Med. Chem., (2009) 52:7:1885	19284718

EC50	10.05	ACS Med. Chem. Lett., (2011) 2:12:929	22778800

EC50	9.77	J Med Chem, (2017) 60:14:6273	28657744

EC50	9.74	J Med Chem, (2017) 60:14:6273	28657744

EC50	9.72	Eur J Med Chem, (2019) 182:None:111626	31445232

EC50	9.72	Eur J Med Chem, (2019) 182:None:111626	31445232

EC50	9.68	J. Med. Chem., (2015) 58:4:1992	25633969

EC50	9.46	Bioorg. Med. Chem. Lett., (2013) 23:11:3411	23602445

EC50	9.4	Bioorg. Med. Chem. Lett., (2013) 23:11:3411	23602445

EC50	9.39	J Med Chem, (2020) 63:9:4579	32282200

HTR7

Tclin

5-hydroxytryptamine receptor 7

33 Activities

Items per page:

1 – 10 of 33

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
	8.3		8394987

Ki	9.96	Eur. J. Med. Chem., (2013) 63:None:85	23466604

Ki	9.89	J. Med. Chem., (2011) 54:15:5320	21726069

Ki	9.77	J Med Chem, (2017) 60:1:349	27997171

Ki	9.66	J. Med. Chem., (2008) 51:22:7094	18983139

IC50	9.6	Bioorg. Med. Chem., (2016) 24:8:1793	26988801

IC50	9.6	Bioorg Med Chem, (2017) 25:2:471	27876250

IC50	9.54	Eur. J. Med. Chem., (2013) 63:None:85	23466604

IC50	9.33	J Med Chem, (2017) 60:1:349	27997171

IC50	9.31	Bioorg. Med. Chem., (2013) 21:10:2764	23582449

HTR2A

Tclin

5-hydroxytryptamine receptor 2A

28 Activities

Items per page:

1 – 10 of 28

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
-	8.9		8534270

EC50	9.57	Eur J Med Chem, (2019) 182:None:111626	31445232

EC50	9.56	Eur J Med Chem, (2019) 182:None:111626	31445232

EC50	9.29	J Nat Prod, (2020) 83:2:461	32077284

EC50	9.29	J Nat Prod, (2020) 83:2:461	32077284

EC50	8.82	Bioorg. Med. Chem. Lett., (2013) 23:11:3411	23602445

EC50	8.81	Bioorg. Med. Chem. Lett., (2013) 23:11:3411	23602445

EC50	8.8	J Med Chem, (2018) 61:22:10017	30383372

EC50	8.73	J. Med. Chem., (2015) 58:4:1992	25633969

EC50	8.63	J Med Chem, (2017) 60:14:6273	28657744

HTR2B

Tclin

5-hydroxytryptamine receptor 2B

22 Activities

Items per page:

1 – 10 of 22

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
	8		8450835

EC50	9.3	J. Med. Chem., (2009) 52:7:1885	19284718

EC50	9.07	ACS Med. Chem. Lett., (2011) 2:12:929	22778800

EC50	9.07	Eur J Med Chem, (2019) 182:None:111626	31445232

EC50	9.07	Eur J Med Chem, (2019) 182:None:111626	31445232

EC50	9.04	J. Med. Chem., (2015) 58:4:1992	25633969

EC50	8.97	Bioorg. Med. Chem. Lett., (2013) 23:11:3411	23602445

EC50	8.96	Bioorg. Med. Chem. Lett., (2013) 23:11:3411	23602445

EC50	8.84	J Med Chem, (2017) 60:14:6273	28657744

EC50	8.84	J Med Chem, (2017) 60:14:6273	28657744

HTR1B

Tclin

5-hydroxytryptamine receptor 1B

20 Activities

Items per page:

1 – 10 of 20

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
-	8.1		1557407

Ki	8.96	J. Med. Chem., (2008) 51:12:3609	18507369

Ki	8.4	J. Med. Chem., (1996) 39:1:314	8568822

Ki	8.4	J. Med. Chem., (1994) 37:18:2828	8071931

Ki	8.4	Eur. J. Med. Chem., (2013) 63:None:85	23466604

EC50	8.33	Bioorg. Med. Chem. Lett., (1998) 8:11:1407	9871775

Ki	8.32	J. Med. Chem., (2003) 46:2:265	12519065

EC50	8.32	J. Med. Chem., (1996) 39:25:4920	8960551

Ki	8.3	J. Med. Chem., (2003) 46:24:5117	14613313

IC50	8.3	J. Med. Chem., (1992) 35:23:4503	1447752

HTR6

Tchem

5-hydroxytryptamine receptor 6

16 Activities

Items per page:

1 – 10 of 16

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
-	7.9		9225298

IC50	7.56	J. Med. Chem., (2010) 53:6:2521	20170099

Ki	7.48	J. Med. Chem., (2014) 57:11:4543	24805037

Ki	7.48	Eur. J. Med. Chem., (2015) 92:None:221	25557493

EC50	7.36	J Med Chem, (2018) 61:22:10017	30383372

Ki	7.3	Eur. J. Med. Chem., (2013) 63:None:85	23466604

Ki	7.21	J Med Chem, (2017) 60:1:349	27997171

Ki	7.19	J. Med. Chem., (2003) 46:14:2795	12825922

Ki	7.16	Med Chem Res, (2005) 14:1:1

Ki	7.12	J. Med. Chem., (2000) 43:5:1011	10715164

HTR1D

Tclin

5-hydroxytryptamine receptor 1D

10 Activities

Items per page:

1 – 10 of 10

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	9.3	J. Med. Chem., (2008) 51:12:3609	18507369

Ki	8.77	J. Med. Chem., (1996) 39:1:314	8568822

Ki	8.7	J. Med. Chem., (1999) 42:3:526	9986723

IC50	8.52	J. Med. Chem., (1990) 33:8:2087	2374139

IC50	8.52	Bioorg. Med. Chem. Lett., (1995) 5:20:2391

Ki	8.52	J. Med. Chem., (1990) 33:2:755	2299641

Ki	8.32	J. Med. Chem., (1995) 38:18:3602	7658447

Ki	8.3	Bioorg. Med. Chem. Lett., (1998) 8:11:1407	9871775

Ki	8.3	J. Med. Chem., (1996) 39:25:4920	8960551

Ki	8.26	J. Med. Chem., (1994) 37:18:2828	8071931

HTR4

Tclin

5-hydroxytryptamine receptor 4

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
-	7.7		8813606

	7.2		8946946

EC50	7.92	J. Med. Chem., (2009) 52:8:2214	19334715

Ki	7.53	Eur. J. Med. Chem., (2009) 44:7:2952	19223092

EC50	7	Nature, (2007) 450:7169:553	18033297

HTR3A

Tclin

5-hydroxytryptamine receptor 3A

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
EC50	6.85	Bioorg. Med. Chem. Lett., (2011) 21:1:58	21146988

EC50	6.75	Bioorg. Med. Chem. Lett., (2011) 21:1:58	21146988

EC50	6.34	J. Med. Chem., (2007) 50:19:4616	17722904

EC50	6.3	J. Med. Chem., (2007) 50:19:4616	17722904

HTR1F

Tclin

5-hydroxytryptamine receptor 1F

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
-	8		8380639

	7.2		8384716

EC50	8.1	J. Med. Chem., (2001) 44:24:4031	11708905

HTR5A

Tchem

5-hydroxytryptamine receptor 5A

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
	6.6		7682702

IC50	7.1	J. Med. Chem., (2005) 48:22:6887	16250647

Ki	7.09	Eur. J. Med. Chem., (2013) 63:None:85	23466604

HTR1E

Tchem

5-hydroxytryptamine receptor 1E

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	8.4	J. Med. Chem., (1990) 33:2:755	2299641

Ki	7.97	Bioorg. Med. Chem. Lett., (2014) 24:2:576	24365159

Ki	7.96	Bioorg. Med. Chem. Lett., (2014) 24:2:576	24365159

DRD1

Tclin

D(1A) dopamine receptor

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
-	5			1826762

DRD5

Tchem

D(1B) dopamine receptor

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
	5.5			1826762

SLC36A1

Tchem

Proton-coupled amino acid transporter 1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	2.2			16126914