Pharos : Ligand Details

Target Activities

HTR7

Tclin

5-hydroxytryptamine receptor 7

22 Activities

Items per page:

1 – 10 of 22

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
EC50	7.77	J. Med. Chem., (2014) 57:15:6879	25073094

Ki	8.09	J. Med. Chem., (2003) 46:14:2795	12825922

Ki	8.22	Eur J Med Chem, (2016) 123:None:180	27475109

EC50	8.24	Eur J Med Chem, (2016) 123:None:180	27475109

EC50	8.24	Eur J Med Chem, (2016) 123:None:180	27475109

Ki	8.4	J. Med. Chem., (2003) 46:14:2795	12825922

Kd	8.4	Eur. J. Med. Chem., (2014) 85:None:716	25128671

Ki	8.5	J. Med. Chem., (2003) 46:24:5117	14613313

IC50	8.59	J. Nat. Prod., (2003) 66:4:535	12713409

IC50	8.82	J. Med. Chem., (2008) 51:14:4150	18588282

HTR1A

Tclin

5-hydroxytryptamine receptor 1A

22 Activities

Items per page:

1 – 10 of 22

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
EC50	7.41	J. Med. Chem., (2013) 56:11:4671	23675993

EC50	7.56	Bioorg. Med. Chem., (2015) 23:15:4824	26081758

EC50	7.81	Eur J Med Chem, (2016) 123:None:332	27487565

Ki	8	J. Med. Chem., (2012) 55:14:6375	22738316

Ki	8.02	Eur. J. Med. Chem., (2013) 69:None:920	24161678

IC50	8.22	J. Med. Chem., (1989) 32:3:543	2918500

IC50	8.25	J. Med. Chem., (1989) 32:3:543	2918500

IC50	8.28	J. Med. Chem., (1992) 35:23:4503	1447752

Ki	8.4	J. Med. Chem., (2003) 46:24:5117	14613313

EC50	8.43	J. Med. Chem., (2003) 46:19:4188	12954071

HTR1B

Tclin

5-hydroxytryptamine receptor 1B

17 Activities

Items per page:

1 – 10 of 17

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
EC50	7.52	J. Med. Chem., (1990) 33:8:2087	2374139

IC50	7.54	J. Med. Chem., (2008) 51:22:7094	18983139

Ki	7.75	J. Med. Chem., (2008) 51:22:7094	18983139

IC50	7.8	J. Med. Chem., (2008) 51:14:4150	18588282

Ki	7.85	J. Med. Chem., (2011) 54:15:5320	21726069

IC50	7.92	Bioorg. Med. Chem., (2013) 21:10:2764	23582449

Ki	8.15	J. Med. Chem., (1995) 38:18:3602	7658447

Ki	8.17	Bioorg. Med. Chem. Lett., (1998) 8:11:1407	9871775

IC50	8.19	Eur. J. Med. Chem., (2013) 63:None:85	23466604

IC50	8.3	J. Med. Chem., (1992) 35:23:4503	1447752

HTR2C

Tclin

5-hydroxytryptamine receptor 2C

16 Activities

Items per page:

1 – 10 of 16

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.09	J. Med. Chem., (1990) 33:8:2087	2374139

Ki	7.1	J. Med. Chem., (2013) 56:3:1211	23301527

Ki	7.1	J. Med. Chem., (2013) 56:3:1211	23301527

EC50	7.29

EC50	7.29	None, (2004) None:None:None

Ki	7.3	J. Med. Chem., (2003) 46:24:5117	14613313

EC50	7.36	J. Med. Chem., (2013) 56:3:1211	23301527

EC50	7.36	J. Med. Chem., (2013) 56:3:1211	23301527

Ki	7.46	J. Med. Chem., (1987) 30:1:1	3543362

Ki	7.7	J. Nat. Prod., (2006) 69:10:1421	17067154

HTR6

Tchem

5-hydroxytryptamine receptor 6

14 Activities

Items per page:

1 – 10 of 14

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	7	Bioorg. Med. Chem. Lett., (2004) 14:17:4569	15357994

IC50	7	Eur. J. Med. Chem., (2013) 63:None:85	23466604

Ki	7	Bioorg. Med. Chem. Lett., (2016) 26:9:2333	26996373

Ki	7.03	J. Med. Chem., (2008) 51:22:7094	18983139

Ki	7.08	J. Med. Chem., (2011) 54:15:5320	21726069

Ki	7.11	Bioorg. Med. Chem. Lett., (2000) 10:20:2295	11055342

Ki	7.12	J. Med. Chem., (2000) 43:5:1011	10715164

Ki	7.16	Med Chem Res, (2005) 14:1:1

Ki	7.19	J. Med. Chem., (2003) 46:14:2795	12825922

Ki	7.3	Eur. J. Med. Chem., (2013) 63:None:85	23466604

HTR2A

Tclin

5-hydroxytryptamine receptor 2A

11 Activities

Items per page:

1 – 10 of 11

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
EC50	7.33	Eur J Med Chem, (2016) 123:None:332	27487565

EC50	7.73

EC50	7.73	None, (2004) None:None:None

EC50	7.8	J. Med. Chem., (2013) 56:11:4671	23675993

Ki	7.85	Bioorg. Med. Chem. Lett., (2004) 14:9:2367	15081042

Ki	7.85	Bioorg. Med. Chem. Lett., (2006) 16:3:677	16257207

EC50	7.96	Bioorg. Med. Chem. Lett., (2006) 16:3:677	16257207

Ki	8.09	J. Med. Chem., (2003) 46:19:4188	12954071

Ki	8.09	J. Med. Chem., (2006) 49:1:318	16392816

EC50	8.73	J. Med. Chem., (2015) 58:4:1992	25633969

HTR2B

Tclin

5-hydroxytryptamine receptor 2B

10 Activities

Items per page:

1 – 10 of 10

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	7.87	Bioorg. Med. Chem. Lett., (2014) 24:6:1489	24582985

Ki	7.89	J. Med. Chem., (2003) 46:19:4188	12954071

Ki	7.89	J. Med. Chem., (2006) 49:1:318	16392816

Ki	7.92	Bioorg. Med. Chem. Lett., (2004) 14:9:2367	15081042

Ki	7.92	Bioorg. Med. Chem. Lett., (2006) 16:3:677	16257207

EC50	8.82	Bioorg. Med. Chem. Lett., (2006) 16:3:677	16257207

EC50	8.96	Bioorg. Med. Chem. Lett., (2013) 23:11:3411	23602445

EC50	8.97	Bioorg. Med. Chem. Lett., (2013) 23:11:3411	23602445

EC50	9.04	J. Med. Chem., (2015) 58:4:1992	25633969

	8		8450835

HTR1D

Tclin

5-hydroxytryptamine receptor 1D

9 Activities

Items per page:

1 – 9 of 9

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	8.26	J. Med. Chem., (1994) 37:18:2828	8071931

Ki	8.3	Bioorg. Med. Chem. Lett., (1998) 8:11:1407	9871775

Ki	8.32	J. Med. Chem., (1995) 38:18:3602	7658447

IC50	8.52	Bioorg. Med. Chem. Lett., (1995) 5:20:2391

IC50	8.52	J. Med. Chem., (1990) 33:8:2087	2374139

Ki	8.52	J. Med. Chem., (1990) 33:2:755	2299641

Ki	8.7	J. Med. Chem., (1999) 42:3:526	9986723

Ki	8.77	J. Med. Chem., (1996) 39:1:314	8568822

Ki	9.3	J. Med. Chem., (2008) 51:12:3609	18507369

HTR4

Tclin

5-hydroxytryptamine receptor 4

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
EC50	7	Nature, (2007) 450:7169:553	18033297

Ki	7.53	Eur. J. Med. Chem., (2009) 44:7:2952	19223092

-	7.69999981		8813606

	7.2		8946946

HTR1E

Tchem

5-hydroxytryptamine receptor 1E

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	7.96	Bioorg. Med. Chem. Lett., (2014) 24:2:576	24365159

Ki	7.97	Bioorg. Med. Chem. Lett., (2014) 24:2:576	24365159

Ki	8.4	J. Med. Chem., (1990) 33:2:755	2299641

HTR5A

Tchem

5-hydroxytryptamine receptor 5A

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	7.09	Eur. J. Med. Chem., (2013) 63:None:85	23466604

	6.6		7682702

HTR1F

Tclin

5-hydroxytryptamine receptor 1F

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Publications (PubMed IDs)
-	8	8380639

	7.2	8384716

ADORA3

Tchem

Adenosine receptor A3

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.1		J. Med. Chem., (2005) 48:22:6887	16250647

DRD1

Tclin

D(1A) dopamine receptor

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
-	5			1826762

DRD5

Tchem

D(1B) dopamine receptor

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
	5.5			1826762

SLC36A1

Tchem

Proton-coupled amino acid transporter 1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	2.2			16126914