Pharos : Ligand Details - LXRDJN426DS6

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Ligand Summary

Ligand Structure

Rendered image for the query structure

Synonyms & Links

Name: adavosertib

PubChem: 24856436

Guide to Pharmacology: 7702

ChEMBL: CHEMBL1976040

LyCHI: LXRDJN426DS6

Target Activities

Explore Associated and Predicted Targets

WEE1

Tchem

Wee1-like protein kinase

5 Activities

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1 – 5 of 5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8.29

Kd	8.49		J Med Chem, (2017) 60:18:7863	28792760

IC50	8.28		Bioorg Med Chem, (2018) 26:14:4014	29941193

Kd	7.92		Science, (2017) 358:6367:None	29191878

Kd	7.87		J Med Chem, (2017) 60:18:7863	28792760

WEE2

Tchem

Wee1-like protein kinase 2

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.41		J Med Chem, (2017) 60:18:7863	28792760

Kd	7.57		J Med Chem, (2017) 60:18:7863	28792760

JAK3

Tclin

Tyrosine-protein kinase JAK3

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.58		J Med Chem, (2017) 60:18:7863	28792760

PLK1

Tchem

Serine/threonine-protein kinase PLK1

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.52		J Med Chem, (2017) 60:18:7863	28792760

ADK

Tchem

Adenosine kinase

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.89		Science, (2017) 358:6367:None	29191878