ibudilast
Ligand Summary
Name: ibudilast
PubChem: 3671
Guide to Pharmacology: 7399
ChEMBL: CHEMBL19449
LyCHI: LKDZKNG3A4N3
Target Activities
PDE4A
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
4 Activities
Items per page:
1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.27 | |||||
IC50 | 7.27 | J. Med. Chem., (2008) 51:18:5471 | ||||
IC50 | 7.27 | J Med Chem, (2020) 63:19:10594 | ||||
EC50 | 6.05 | J. Med. Chem., (2011) 54:9:3331 | ||||
PDE4B
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
3 Activities
PDE4C
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
3 Activities
PDE4D
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
2 Activities
PDE3A
cGMP-inhibited 3',5'-cyclic phosphodiesterase A
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 3.52 | |||||
PDE5A
cGMP-specific 3',5'-cyclic phosphodiesterase
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 3.99 | |||||
CYP1A2
Cytochrome P450 1A2
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
AC50 | 6.2 | None, None:None:None | ||||
CYP2D6
Cytochrome P450 2D6
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
AC50 | 7.4 | None, None:None:None | ||||