EPZ004777
Ligand Summary
Name: EPZ004777
PubChem: 56962336
Guide to Pharmacology: 7377
ChEMBL: CHEMBL2169919
LyCHI: KVPTVLBPCCC6
Target Activities
DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific
16 Activities
Items per page:
1 – 10 of 16
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 9.4 | |||||
Kd | 9.6 | J. Med. Chem., (2015) 58:4:1596 | ||||
Ki | 9.52 | J. Med. Chem., (2013) 56:22:8972 | ||||
Ki | 9.52 | MedChemComm, (2013) 4:5:822 | ||||
Ki | 9.52 | J. Med. Chem., (2015) 58:4:1596 | ||||
Ki | 9.52 | J. Med. Chem., (2015) 58:4:1596 | ||||
Ki | 9.52 | Bioorg Med Chem Lett, (2016) 26:18:4518 | ||||
IC50 | 9.4 | Eur. J. Med. Chem., (2012) 56:None:179 | ||||
IC50 | 9.4 | Bioorg. Med. Chem., (2013) 21:7:1787 | ||||
IC50 | 9.4 | MedChemComm, (2012) 3:2:135 | ||||