Pharos : Ligand Details - K4MA9GZJG58A

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Ligand Summary

Ligand Structure

Rendered image for the query structure

Synonyms & Links

Name: US8937193, 6i

ChEMBL: CHEMBL1269107

LyCHI: K4MA9GZJG58A

Target Activities

Explore Associated and Predicted Targets

BCL2L1

Tchem

Bcl-2-like protein 1

7 Activities

Items per page:

1 – 7 of 7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.12		J Med Chem, (2017) 60:3:821	27749061

Ki	7.12		Eur J Med Chem, (2019) 177:None:63	31129454

Ki	6.64		J. Med. Chem., (2010) 53:22:8000	21033669

IC50	6.47		J. Med. Chem., (2010) 53:22:8000	21033669

IC50	6.47		None, (2015) None:None:None

Kd	6.35		J. Med. Chem., (2010) 53:22:8000	21033669

Kd	6.35		None, (2015) None:None:None

MCL1

Tchem

Induced myeloid leukemia cell differentiation protein Mcl-1

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.6		J Med Chem, (2017) 60:3:821	27749061

Ki	7.6		Eur J Med Chem, (2019) 177:None:63	31129454

Ki	6.8		J. Med. Chem., (2010) 53:22:8000	21033669

IC50	6.62		J. Med. Chem., (2010) 53:22:8000	21033669

IC50	6.62		None, (2015) None:None:None

BCL2

Tclin

Apoptosis regulator Bcl-2

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.51		J Med Chem, (2017) 60:3:821	27749061

Ki	7.51		Eur J Med Chem, (2019) 177:None:63	31129454

Ki	6.72		J. Med. Chem., (2010) 53:22:8000	21033669

IC50	6.54		J. Med. Chem., (2010) 53:22:8000	21033669

IC50	6.54		None, (2015) None:None:None

BCL2A1

Tchem

Bcl-2-related protein A1

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.91		J Med Chem, (2017) 60:3:821	27749061

Ki	6.37		J. Med. Chem., (2010) 53:22:8000	21033669

IC50	6.19		J. Med. Chem., (2010) 53:22:8000	21033669

IC50	6.19		None, (2015) None:None:None