Pharos : Ligand Details

Target Activities

FLT3

Tclin

Receptor-type tyrosine-protein kinase FLT3

21 Activities

Items per page:

1 – 10 of 21

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.39999962		16648571

Kd	9.19999981		22037378

Kd	9.2	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	9.2	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.89	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.59	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	8.59	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.57	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	8.57	Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	8.4	J Med Chem, (2018) 61:12:5073	29266937

KDR

Tclin

Vascular endothelial growth factor receptor 2

15 Activities

Items per page:

1 – 10 of 15

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.39999962		16648571

IC50	8.64	ACS Med. Chem. Lett., (2014) 5:5:592	24900886

IC50	8.4	J. Med. Chem., (2007) 50:7:1584	17343372

IC50	8.4	J. Med. Chem., (2007) 50:7:1584	17343372

IC50	8.4	Bioorg. Med. Chem. Lett., (2008) 18:1:386	18023347

IC50	8.4	J Med Chem, (2018) 61:12:5073	29266937

IC50	8.3	Bioorg. Med. Chem., (2011) 19:14:4173	21708468

IC50	8.21	ACS Med. Chem. Lett., (2014) 5:5:592	24900886

IC50	8.15	Bioorg. Med. Chem. Lett., (2012) 22:14:4654	22726931

IC50	8.15	Bioorg. Med. Chem., (2013) 21:11:2856	23618709

KIT

Tclin

Mast/stem cell growth factor receptor Kit

15 Activities

Items per page:

1 – 10 of 15

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.8499999		16648571

Kd	8.77	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	8.77	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.72	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.7	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	8.7	Eur. J. Med. Chem., (2011) 46:6:2043	21429632

Kd	8.7	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.42	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	8.42	Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	7.85	J Med Chem, (2018) 61:12:5073	29266937

CSF1R

Tclin

Macrophage colony-stimulating factor 1 receptor

6 Activities

Items per page:

1 – 6 of 6

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.52000046		16648571

IC50	8.52	J. Med. Chem., (2007) 50:7:1584	17343372

IC50	8.52	J Med Chem, (2018) 61:12:5073	29266937

Kd	8.47	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	8.47	Nat. Biotechnol., (2011) 29:11:1046	22037378

Ki	8.1	None, None:None:None

FLT1

Tclin

Vascular endothelial growth factor receptor 1

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.52000046		16648571

IC50	8.52	J. Med. Chem., (2007) 50:7:1584	17343372

IC50	8.52	J Med Chem, (2018) 61:12:5073	29266937

Kd	8.12	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	8.12	Nat. Biotechnol., (2011) 29:11:1046	22037378

FLT4

Tclin

Vascular endothelial growth factor receptor 3

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	6.71999979		16648571

Ki	8	None, None:None:None

IC50	7.9	J. Med. Chem., (2013) 56:17:6991	23937569

Kd	7.8	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	7.8	Nat. Biotechnol., (2011) 29:11:1046	22037378

PDGFRB

Tclin

Platelet-derived growth factor receptor beta

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.17999983		16648571

Kd	8.72	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	8.72	Nat. Biotechnol., (2011) 29:11:1046	22037378

Ki	8.4	None, None:None:None

CDK8

Tchem

Cyclin-dependent kinase 8

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.15999985		26502155

Ki	9	None, None:None:None

IC50	7.85	J Med Chem, (2018) 61:12:5073	29266937

PDGFRA

Tclin

Platelet-derived growth factor receptor alpha

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.38	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	8.38	Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	7.82	J Med Chem, (2017) 60:12:5099	28541695

CDK19

Tchem

Cyclin-dependent kinase 19

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.92000008		26502155

IC50	7.62	J Med Chem, (2018) 61:12:5073	29266937

MUSK

Tchem

Muscle, skeletal receptor tyrosine-protein kinase

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	8	Nat. Biotechnol., (2011) 29:11:1046	22037378

RET

Tclin

Proto-oncogene tyrosine-protein kinase receptor Ret

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	5.71999979			16648571

TEK

Tclin

Angiopoietin-1 receptor

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.76999998			16648571

FRK

Tchem

Tyrosine-protein kinase FRK

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.7		None, None:None:None

CMPK1

Tchem

UMP-CMP kinase

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.22		Science, (2017) 358:6367:None	29191878

SMO

Tclin

Smoothened homolog

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.06		J Med Chem, (2017) 60:17:7447	28787156