linifanib
Ligand Summary
Name: linifanib
PubChem: 11485656
Guide to Pharmacology: 5657
ChEMBL: CHEMBL223360
LyCHI: JUWYAYT6Q9TY
Target Activities
FLT3
Receptor-type tyrosine-protein kinase FLT3
21 Activities
Items per page:
1 – 10 of 21
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 8.4 | |||||
Kd | 9.2 | |||||
Kd | 9.2 | Nat. Biotechnol., (2008) 26:1:127 | ||||
Kd | 9.2 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.89 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.59 | Nat. Biotechnol., (2008) 26:1:127 | ||||
Kd | 8.59 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.57 | Nat. Biotechnol., (2008) 26:1:127 | ||||
Kd | 8.57 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
IC50 | 8.4 | J Med Chem, (2018) 61:12:5073 | ||||
KDR
Vascular endothelial growth factor receptor 2
15 Activities
Items per page:
1 – 10 of 15
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 8.4 | |||||
IC50 | 8.64 | ACS Med. Chem. Lett., (2014) 5:5:592 | ||||
IC50 | 8.4 | J. Med. Chem., (2007) 50:7:1584 | ||||
IC50 | 8.4 | J. Med. Chem., (2007) 50:7:1584 | ||||
IC50 | 8.4 | Bioorg. Med. Chem. Lett., (2008) 18:1:386 | ||||
IC50 | 8.4 | J Med Chem, (2018) 61:12:5073 | ||||
IC50 | 8.3 | Bioorg. Med. Chem., (2011) 19:14:4173 | ||||
IC50 | 8.21 | ACS Med. Chem. Lett., (2014) 5:5:592 | ||||
IC50 | 8.15 | Bioorg. Med. Chem. Lett., (2012) 22:14:4654 | ||||
IC50 | 8.15 | Bioorg. Med. Chem., (2013) 21:11:2856 | ||||
KIT
Mast/stem cell growth factor receptor Kit
15 Activities
Items per page:
1 – 10 of 15
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 7.85 | |||||
Kd | 8.77 | Nat. Biotechnol., (2008) 26:1:127 | ||||
Kd | 8.77 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.72 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.7 | Nat. Biotechnol., (2008) 26:1:127 | ||||
Kd | 8.7 | Eur. J. Med. Chem., (2011) 46:6:2043 | ||||
Kd | 8.7 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.42 | Nat. Biotechnol., (2008) 26:1:127 | ||||
Kd | 8.42 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
IC50 | 7.85 | J Med Chem, (2018) 61:12:5073 | ||||
CSF1R
Macrophage colony-stimulating factor 1 receptor
6 Activities
Items per page:
1 – 6 of 6
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 8.52 | |||||
IC50 | 8.52 | J. Med. Chem., (2007) 50:7:1584 | ||||
IC50 | 8.52 | J Med Chem, (2018) 61:12:5073 | ||||
Kd | 8.47 | Nat. Biotechnol., (2008) 26:1:127 | ||||
Kd | 8.47 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Ki | 8.1 | None, None:None:None | ||||
FLT1
Vascular endothelial growth factor receptor 1
5 Activities
Items per page:
1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 8.52 | |||||
IC50 | 8.52 | J. Med. Chem., (2007) 50:7:1584 | ||||
IC50 | 8.52 | J Med Chem, (2018) 61:12:5073 | ||||
Kd | 8.12 | Nat. Biotechnol., (2008) 26:1:127 | ||||
Kd | 8.12 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
FLT4
Vascular endothelial growth factor receptor 3
5 Activities
Items per page:
1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 6.72 | |||||
Ki | 8 | None, None:None:None | ||||
IC50 | 7.9 | J. Med. Chem., (2013) 56:17:6991 | ||||
Kd | 7.8 | Nat. Biotechnol., (2008) 26:1:127 | ||||
Kd | 7.8 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
PDGFRB
Platelet-derived growth factor receptor beta
4 Activities
CDK8
Cyclin-dependent kinase 8
3 Activities
PDGFRA
Platelet-derived growth factor receptor alpha
3 Activities
CDK19
Cyclin-dependent kinase 19
2 Activities
MUSK
Muscle, skeletal receptor tyrosine-protein kinase
2 Activities
RET
Proto-oncogene tyrosine-protein kinase receptor Ret
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 5.72 | |||||
TEK
Angiopoietin-1 receptor
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 6.77 | |||||
FRK
Tyrosine-protein kinase FRK
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 7.7 | None, None:None:None | ||||
CMPK1
UMP-CMP kinase
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.22 | Science, (2017) 358:6367:None | ||||
SMO
Smoothened homolog
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 7.06 | J Med Chem, (2017) 60:17:7447 | ||||