Pharos : Ligand Details

Target Activities

Items per page:

1 – 10 of 13

FLT3

Tclin

Receptor-type tyrosine-protein kinase FLT3

18 Activities

Items per page:

1 – 10 of 18

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.7	Bioorg. Med. Chem., (2011) 19:14:4173	21708468

IC50	7.7	Bioorg. Med. Chem. Lett., (2012) 22:14:4654	22726931

IC50	7.7	Bioorg. Med. Chem., (2013) 21:11:2856	23618709

Kd	7.8	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.96	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.96	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	8.06	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.06	Nat. Biotechnol., (2008) 26:1:127	18183025

IC50	8.3	J. Med. Chem., (2007) 50:7:1584	17343372

Kd	8.57	Nat. Biotechnol., (2011) 29:11:1046	22037378

KIT

Tclin

Mast/stem cell growth factor receptor Kit

14 Activities

Items per page:

1 – 10 of 14

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.68	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.68	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	7.77	Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	7.8	Eur. J. Med. Chem., (2010) 45:1:393	19892442

IC50	7.8	J. Med. Chem., (2007) 50:7:1584	17343372

Kd	8.42	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.42	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	8.7	Eur. J. Med. Chem., (2011) 46:6:2043	21429632

Kd	8.7	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.7	Nat. Biotechnol., (2008) 26:1:127	18183025

KDR

Tclin

Vascular endothelial growth factor receptor 2

11 Activities

Items per page:

1 – 10 of 11

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.55	J. Med. Chem., (2008) 51:13:3777	18557606

Kd	8.09	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.09	Nat. Biotechnol., (2008) 26:1:127	18183025

IC50	8.15	Bioorg. Med. Chem. Lett., (2012) 22:14:4654	22726931

IC50	8.15	Bioorg. Med. Chem., (2013) 21:11:2856	23618709

IC50	8.21	ACS Med. Chem. Lett., (2014) 5:5:592	24900886

IC50	8.3	Bioorg. Med. Chem., (2011) 19:14:4173	21708468

IC50	8.4	Bioorg. Med. Chem. Lett., (2008) 18:1:386	18023347

IC50	8.4	J. Med. Chem., (2007) 50:7:1584	17343372

IC50	8.64	ACS Med. Chem. Lett., (2014) 5:5:592	24900886

CSF1R

Tclin

Macrophage colony-stimulating factor 1 receptor

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.47	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.47	Nat. Biotechnol., (2008) 26:1:127	18183025

IC50	8.52	J. Med. Chem., (2007) 50:7:1584	17343372

IC50	8.52000046		16648571

FLT1

Tclin

Vascular endothelial growth factor receptor 1

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.12	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.12	Nat. Biotechnol., (2008) 26:1:127	18183025

IC50	8.52	J. Med. Chem., (2007) 50:7:1584	17343372

IC50	8.52000046		16648571

FLT4

Tclin

Vascular endothelial growth factor receptor 3

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.8	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.8	Nat. Biotechnol., (2008) 26:1:127	18183025

IC50	7.9	J. Med. Chem., (2013) 56:17:6991	23937569

IC50	6.71999979		16648571

PDGFRB

Tclin

Platelet-derived growth factor receptor beta

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.72	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.72	Nat. Biotechnol., (2008) 26:1:127	18183025

IC50	7.17999983		16648571

MUSK

Tchem

Muscle, skeletal receptor tyrosine-protein kinase

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8	Nat. Biotechnol., (2008) 26:1:127	18183025

PDGFRA

Tclin

Platelet-derived growth factor receptor alpha

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.38	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.38	Nat. Biotechnol., (2008) 26:1:127	18183025

CDK19

Tchem

Cyclin-dependent kinase 19

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.92000008			26502155