Pharos : Ligand Details - JRA4JW5XM7SZ

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Ligand Summary

Ligand Structure

chemical structure image

Synonyms & Links

Name: (E)-(2-(hydroxymethyl)-4-((1-methyl-1H-indol-3-yl)methylene)-5-oxotetrahydrofuran-2-yl)methyl 2-propylpentanoate

PubChem: 25053598

Guide to Pharmacology: 10066

ChEMBL: CHEMBL519741

LyCHI: JRA4JW5XM7SZ

Target Activities

PRKCA

Tchem

Protein kinase C alpha type

3 Activities

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1 – 3 of 3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.53		J. Med. Chem., (2008) 51:17:5371	18707088

Ki	7.79		Bioorg. Med. Chem., (2014) 22:12:3123	24794745

Ki	7.78999996			24794745

RASGRP1

Tchem

RAS guanyl-releasing protein 1

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	9.6		Bioorg. Med. Chem., (2014) 22:12:3123	24794745

Ki	9.60000038			24794745

RASGRP3

Tchem

Ras guanyl-releasing protein 3

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	9.48		Bioorg. Med. Chem., (2014) 22:12:3123	24794745

Ki	9.74		J. Med. Chem., (2008) 51:17:5371	18707088

PRKCE

Tchem

Protein kinase C epsilon type

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.68		Bioorg. Med. Chem., (2014) 22:12:3123	24794745

Ki	7.67999983			24794745