CHEMBL603469
Ligand Summary
Name: 16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^{15,18}.0^{2,6}.0^{7,27}.0^{8,13}.0^{19,26}.0^{20,25}]octacosa-1(26),2(6),7(27),8(13),9,11,20(25),21,23-nonaen-3-one
PubChem: 126565
Guide to Pharmacology: 5672
ChEMBL: CHEMBL603469
LyCHI: JJKPSGPHHFRR
Target Activities
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10
1 – 10 of 122
FLT3
Receptor-type tyrosine-protein kinase FLT3
16 Activities
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1 – 10 of 16
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 8.07 | Blood, (2009) 114:14:2984 | ||||
Kd | 8.07 | Blood, (2009) 114:14:2984 | ||||
Kd | 8.07 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.07 | J. Med. Chem., (2013) 56:20:8032 | ||||
IC50 | 8.09 | Bioorg. Med. Chem. Lett., (2013) 23:6:1768 | ||||
Kd | 8.15 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.27 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
IC50 | 8.3 | Bioorg. Med. Chem. Lett., (2010) 20:6:2033 | ||||
IC50 | 8.59 | Blood, (2009) 114:14:2984 | ||||
IC50 | 8.6 | MedChemComm, (2012) 3:1:22 | ||||
RET
Proto-oncogene tyrosine-protein kinase receptor Ret
5 Activities
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1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 7.7 | Blood, (2009) 114:14:2984 | ||||
Kd | 7.7 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 7.85 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.17 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.33 | Nat. Biotechnol., (2011) 29:11:1046 | ||||