lestaurtinib
Ligand Summary
Name: lestaurtinib
PubChem: 126565
Guide to Pharmacology: 5672
ChEMBL: CHEMBL603469
LyCHI: JJKPSGPHHFRR
Target Activities
FLT3
Receptor-type tyrosine-protein kinase FLT3
20 Activities
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1 – 10 of 20
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 8.07 | |||||
Kd | 9.24 | Blood, (2009) 114:14:2984 | ||||
Kd | 9.24 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 9.18 | Blood, (2009) 114:14:2984 | ||||
Kd | 9.18 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.85 | Blood, (2009) 114:14:2984 | ||||
Kd | 8.85 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
IC50 | 8.82 | Blood, (2009) 114:14:2984 | ||||
Kd | 8.82 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
IC50 | 8.6 | MedChemComm, (2012) 3:1:22 | ||||
RET
Proto-oncogene tyrosine-protein kinase receptor Ret
8 Activities
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1 – 8 of 8
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 8.33 | Blood, (2009) 114:14:2984 | ||||
Kd | 8.33 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.17 | Blood, (2009) 114:14:2984 | ||||
Kd | 8.17 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 7.85 | Blood, (2009) 114:14:2984 | ||||
Kd | 7.85 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 7.7 | Blood, (2009) 114:14:2984 | ||||
Kd | 7.7 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
MYLK
Myosin light chain kinase, smooth muscle
3 Activities
KIT
Mast/stem cell growth factor receptor Kit
3 Activities
MAPK10
Mitogen-activated protein kinase 10
3 Activities
PAK4
Serine/threonine-protein kinase PAK 4
3 Activities
MAP3K11
Mitogen-activated protein kinase kinase kinase 11
3 Activities
AURKA
Aurora kinase A
3 Activities
MAPK8
Mitogen-activated protein kinase 8
2 Activities
DYRK1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
2 Activities
PHKG2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform
2 Activities
CDK2
Cyclin-dependent kinase 2
2 Activities
PDPK1
3-phosphoinositide-dependent protein kinase 1
2 Activities
EGFR
Epidermal growth factor receptor
2 Activities
PDGFRB
Platelet-derived growth factor receptor beta
2 Activities
FLT4
Vascular endothelial growth factor receptor 3
2 Activities
IKBKB
Inhibitor of nuclear factor kappa-B kinase subunit beta
2 Activities
MAP2K3
Dual specificity mitogen-activated protein kinase kinase 3
2 Activities
JAK3
Tyrosine-protein kinase JAK3
2 Activities
SYK
Tyrosine-protein kinase SYK
2 Activities
ZAP70
Tyrosine-protein kinase ZAP-70
2 Activities
NTRK1
High affinity nerve growth factor receptor
2 Activities
JAK1
Tyrosine-protein kinase JAK1
2 Activities
PRKG2
cGMP-dependent protein kinase 2
2 Activities
MAP2K4
Dual specificity mitogen-activated protein kinase kinase 4
2 Activities
MAP2K2
Dual specificity mitogen-activated protein kinase kinase 2
2 Activities
JAK2
Tyrosine-protein kinase JAK2
2 Activities
CAMK2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma
2 Activities
AAK1
AP2-associated protein kinase 1
2 Activities
MARK2
Serine/threonine-protein kinase MARK2
2 Activities
PRKD1
Serine/threonine-protein kinase D1
2 Activities
AURKC
Aurora kinase C
2 Activities
STK16
Serine/threonine-protein kinase 16
2 Activities
IRAK1
Interleukin-1 receptor-associated kinase 1
2 Activities
IKBKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon
2 Activities
TYK2
Non-receptor tyrosine-protein kinase TYK2
2 Activities
MAP2K1
Dual specificity mitogen-activated protein kinase kinase 1
2 Activities
STK17B
Serine/threonine-protein kinase 17B
2 Activities
STK10
Serine/threonine-protein kinase 10
2 Activities
FER
Tyrosine-protein kinase Fer
2 Activities
PHKG1
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
2 Activities
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