CHEMBL4128926
Ligand Summary
Name: 3-[[5-[4-(tert-butylsulfamoyl)-1-naphthyl]-4-(cyclohexylmethyl)thiazole-2-carbonyl]amino]cyclobutanecarboxylic acid
ChEMBL: CHEMBL4128926
LyCHI: JAPU34M73NR9
Target Activities
RORC
Nuclear receptor ROR-gamma
6 Activities
Items per page:
1 – 6 of 6
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 9.92 | Bioorg Med Chem Lett, (2018) 28:9:1446 | ||||
Kd | 9.92 | Bioorg Med Chem Lett, (2020) 30:12:127174 | ||||
IC50 | 9.03 | Bioorg Med Chem Lett, (2018) 28:9:1446 | ||||
IC50 | 8.7 | Bioorg Med Chem Lett, (2020) 30:12:127174 | ||||
EC50 | 8.55 | Bioorg Med Chem Lett, (2018) 28:9:1446 | ||||
EC50 | 7.09 | Bioorg Med Chem Lett, (2018) 28:9:1446 | ||||
TACR2
Substance-K receptor
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.92 | Bioorg Med Chem Lett, (2018) 28:9:1446 | ||||
CCR1
C-C chemokine receptor type 1
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 10.09 | Bioorg Med Chem Lett, (2018) 28:9:1446 | ||||
CXCR2
C-X-C chemokine receptor type 2
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 9.62 | Bioorg Med Chem Lett, (2018) 28:9:1446 | ||||
CHRM3
Muscarinic acetylcholine receptor M3
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 9.14 | Bioorg Med Chem Lett, (2018) 28:9:1446 | ||||
HRH1
Histamine H1 receptor
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.77 | Bioorg Med Chem Lett, (2018) 28:9:1446 | ||||
DRD2
D(2) dopamine receptor
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.74 | Bioorg Med Chem Lett, (2018) 28:9:1446 | ||||
AGTR1
Type-1 angiotensin II receptor
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 9.33 | Bioorg Med Chem Lett, (2018) 28:9:1446 | ||||
HTR2B
5-hydroxytryptamine receptor 2B
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.49 | Bioorg Med Chem Lett, (2018) 28:9:1446 | ||||
CHRM1
Muscarinic acetylcholine receptor M1
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.75 | Bioorg Med Chem Lett, (2018) 28:9:1446 | ||||
AVPR1A
Vasopressin V1a receptor
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.96 | Bioorg Med Chem Lett, (2018) 28:9:1446 | ||||
HTR3A
5-hydroxytryptamine receptor 3A
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.31 | Bioorg Med Chem Lett, (2018) 28:9:1446 | ||||
CCKAR
Cholecystokinin receptor type A
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 9.92 | Bioorg Med Chem Lett, (2018) 28:9:1446 | ||||
SLC6A4
Sodium-dependent serotonin transporter
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.77 | Bioorg Med Chem Lett, (2018) 28:9:1446 | ||||
EDNRA
Endothelin-1 receptor
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 10.64 | Bioorg Med Chem Lett, (2018) 28:9:1446 | ||||
OPRD1
Delta-type opioid receptor
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.22 | Bioorg Med Chem Lett, (2018) 28:9:1446 | ||||
HTR1A
5-hydroxytryptamine receptor 1A
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 9.37 | Bioorg Med Chem Lett, (2018) 28:9:1446 | ||||
MTNR1A
Melatonin receptor type 1A
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 9.77 | Bioorg Med Chem Lett, (2018) 28:9:1446 | ||||
ADORA3
Adenosine receptor A3
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 9.77 | Bioorg Med Chem Lett, (2018) 28:9:1446 | ||||
HTR2A
5-hydroxytryptamine receptor 2A
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 9.19 | Bioorg Med Chem Lett, (2018) 28:9:1446 | ||||
ADORA2A
Adenosine receptor A2a
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.04 | Bioorg Med Chem Lett, (2018) 28:9:1446 | ||||
SLC6A3
Sodium-dependent dopamine transporter
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.31 | Bioorg Med Chem Lett, (2018) 28:9:1446 | ||||
OPRM1
Mu-type opioid receptor
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.96 | Bioorg Med Chem Lett, (2018) 28:9:1446 | ||||
DRD1
D(1A) dopamine receptor
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 9.68 | Bioorg Med Chem Lett, (2018) 28:9:1446 | ||||
SLC6A2
Sodium-dependent noradrenaline transporter
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.47 | Bioorg Med Chem Lett, (2018) 28:9:1446 | ||||
HTR7
5-hydroxytryptamine receptor 7
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 9.41 | Bioorg Med Chem Lett, (2018) 28:9:1446 | ||||
BDKRB2
B2 bradykinin receptor
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.68 | Bioorg Med Chem Lett, (2018) 28:9:1446 | ||||
GALR2
Galanin receptor type 2
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 9.72 | Bioorg Med Chem Lett, (2018) 28:9:1446 | ||||
MC4R
Melanocortin receptor 4
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 9.68 | Bioorg Med Chem Lett, (2018) 28:9:1446 | ||||
NPY2R
Neuropeptide Y receptor type 2
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 9.55 | Bioorg Med Chem Lett, (2018) 28:9:1446 | ||||
NTSR1
Neurotensin receptor type 1
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 9.6 | Bioorg Med Chem Lett, (2018) 28:9:1446 | ||||
TACR3
Neuromedin-K receptor
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.09 | Bioorg Med Chem Lett, (2018) 28:9:1446 | ||||
NPY1R
Neuropeptide Y receptor type 1
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 9.89 | Bioorg Med Chem Lett, (2018) 28:9:1446 | ||||
VIPR1
Vasoactive intestinal polypeptide receptor 1
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 9.33 | Bioorg Med Chem Lett, (2018) 28:9:1446 | ||||
OPRK1
Kappa-type opioid receptor
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.96 | Bioorg Med Chem Lett, (2018) 28:9:1446 | ||||
OPRL1
Nociceptin receptor
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 9.01 | Bioorg Med Chem Lett, (2018) 28:9:1446 | ||||
ADORA1
Adenosine receptor A1
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 9.21 | Bioorg Med Chem Lett, (2018) 28:9:1446 | ||||
CHRM2
Muscarinic acetylcholine receptor M2
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.32 | Bioorg Med Chem Lett, (2018) 28:9:1446 | ||||