Pharos : Ligand Details

Target Activities

Explore Associated and Predicted Targets

EZH2

Tclin

Histone-lysine N-methyltransferase EZH2

12 Activities

Items per page:

1 – 10 of 12

Activity Type	Activity Value -log(M)	Activity Reference
IC50	6.58	None, (2014) None:None:None

IC50	6.58	None, (2015) None:None:None

IC50	6.58	None, (2016) None:None:None

IC50	6.55	None, (2014) None:None:None

IC50	6.55	None, (2015) None:None:None

IC50	6.55	None, (2016) None:None:None

IC50	6.42	None, (2014) None:None:None

IC50	6.42	None, (2015) None:None:None

IC50	6.42	None, (2016) None:None:None

IC50	6.33	None, (2014) None:None:None

DOT1L

Tchem

Histone-lysine N-methyltransferase, H3 lysine-79 specific

8 Activities

Items per page:

1 – 8 of 8

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	6.82	J. Med. Chem., (2012) 55:18:8066	22924785

Ki	6.8	J. Med. Chem., (2012) 55:18:8066	22924785

Ki	6.8	J. Med. Chem., (2013) 56:22:8972	23879463

IC50	6.66	Bioorg Med Chem Lett, (2016) 26:18:4518	27485386

Ki	6.57	J Med Chem, (2019) 62:22:10005	31188592

Kd	6.44	J. Med. Chem., (2012) 55:18:8066	22924785

IC50	6.22	Bioorg. Med. Chem., (2013) 21:7:1787	23433670

IC50	6.22	Bioorg. Med. Chem., (2013) 21:7:1787	23433670

DNMT1

Tclin

DNA (cytosine-5)-methyltransferase 1

6 Activities

Items per page:

1 – 6 of 6

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.15	Eur J Med Chem, (2020) 189:None:112023	31978781

IC50	6.7	Bioorg Med Chem Lett, (2016) 26:18:4518	27485386

IC50	6.22	Bioorg Med Chem Lett, (2019) 29:6:826	30704813

IC50	6.1	Bioorg. Med. Chem. Lett., (2009) 19:10:2742	19364644

IC50	6.05	J. Med. Chem., (2012) 55:4:1731	22280363

IC50	6.03	Bioorg. Med. Chem. Lett., (2012) 22:9:3079	22483584

PRMT1

Tchem

Protein arginine N-methyltransferase 1

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	6.4	J. Med. Chem., (2012) 55:18:8066	22924785

IC50	6.38	J. Med. Chem., (2015) 58:3:1228	25559100

IC50	6.3	Bioorg. Med. Chem. Lett., (2015) 25:22:5449	26428871

IC50	6.26	Bioorg Med Chem Lett, (2017) 27:20:4635	28927791

DNMT3B

Tchem

DNA (cytosine-5)-methyltransferase 3B

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	6.7	Bioorg. Med. Chem. Lett., (2009) 19:10:2742	19364644

IC50	6.6	Bioorg. Med. Chem., (2010) 18:2:822	20006515

IC50	6.52	Bioorg. Med. Chem. Lett., (2009) 19:10:2747	19362833

CARM1

Tchem

Histone-arginine methyltransferase CARM1

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	6.4	J. Med. Chem., (2013) 56:22:8972	23879463

Ki	6.07	J. Med. Chem., (2012) 55:18:8066	22924785

PRMT3

Tchem

Protein arginine N-methyltransferase 3

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	6.96	Eur J Med Chem, (2020) 189:None:112023	31978781

IC50	6.12	Eur J Med Chem, (2020) 189:None:112023	31978781

EHMT1

Tchem

Histone-lysine N-methyltransferase EHMT1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.64		Bioorg. Med. Chem. Lett., (2015) 25:7:1532	25746813

EHMT2

Tchem

Histone-lysine N-methyltransferase EHMT2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	6.24		J. Med. Chem., (2013) 56:22:8972	23879463

PRMT5

Tchem

Protein arginine N-methyltransferase 5

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.7		Bioorg Med Chem Lett, (2016) 26:18:4518	27485386

SMYD2

Tchem

N-lysine methyltransferase SMYD2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.75		Bioorg. Med. Chem. Lett., (2015) 25:7:1532	25746813

PRMT7

Tchem

Protein arginine N-methyltransferase 7

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.96		Eur J Med Chem, (2020) 189:None:112023	31978781