Pharos : Ligand Details - J81WZ3Y3MPRC

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Ligand Summary

Ligand Structure

Rendered image for the query structure

Synonyms & Links

Name: rocaglamide

PubChem: 331783

ChEMBL: CHEMBL438139

LyCHI: J81WZ3Y3MPRC

Target Activities

Explore Associated and Predicted Targets

RELA

Tchem

Transcription factor p65

5 Activities

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1 – 5 of 5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.16		Bioorg Med Chem, (2018) 26:15:4452	30057155

IC50	7.12		J. Nat. Prod., (2011) 74:5:1117	21428375

IC50	7.12		J. Nat. Prod., (2011) 74:5:1126	21513293

IC50	7.1		J. Nat. Prod., (2009) 72:11:2028	19839614

IC50	6.92		J Nat Prod, (2019) 82:6:1645	31120251

EIF4A1

Tchem

Eukaryotic initiation factor 4A-I

5 Activities

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1 – 5 of 5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8.33		J Med Chem, (2020) 63:11:5879	32470302

IC50	7.33		J Med Chem, (2020) 63:11:5879	32470302

IC50	6.87		J Med Chem, (2020) 63:11:5879	32470302

Kd	6.81		J Med Chem, (2020) 63:11:5879	32470302

IC50	6.64		J Med Chem, (2020) 63:11:5879	32470302

NFKB1

Tclin

Nuclear factor NF-kappa-B p105 subunit

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.12		J. Nat. Prod., (2010) 73:5:949	20384315