Pharos : Ligand Details

Target Activities

Explore Associated and Predicted Targets

MET

Tclin

Hepatocyte growth factor receptor

52 Activities

Items per page:

1 – 10 of 52

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.85		22037378

IC50	9.4	Eur. J. Med. Chem., (2013) 64:None:62	23644189

IC50	9.4	Eur. J. Med. Chem., (2014) 80:None:254	24792774

IC50	9.4	Eur. J. Med. Chem., (2014) 83:None:581	24996144

IC50	9.4	Eur. J. Med. Chem., (2015) 90:None:195	25461320

IC50	9.4	Eur. J. Med. Chem., (2016) 108:None:495	26717201

IC50	9.4	J. Med. Chem., (2016) 59:8:3593	26555154

IC50	9.4	Bioorg. Med. Chem., (2016) 24:16:3353	27068889

IC50	9.4	J Med Chem, (2016) 59:19:8712	27299736

IC50	9.4	Eur J Med Chem, (2016) 123:None:431	27490023

KDR

Tclin

Vascular endothelial growth factor receptor 2

16 Activities

Items per page:

1 – 10 of 16

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	9.1	Eur. J. Med. Chem., (2013) 64:None:62	23644189

IC50	9.1	Eur. J. Med. Chem., (2014) 83:None:581	24996144

IC50	9.07	J Med Chem, (2016) 59:19:8712	27299736

IC50	9.07	Eur J Med Chem, (2016) 123:None:431	27490023

IC50	9.07	Eur J Med Chem, (2018) 158:None:814	30248654

IC50	9.05	Eur. J. Med. Chem., (2016) 108:None:495	26717201

IC50	9.05	J. Med. Chem., (2016) 59:8:3593	26555154

IC50	9.05	Bioorg. Med. Chem., (2016) 24:16:3353	27068889

IC50	8.82	Bioorg Med Chem, (2019) 27:13:2801	31079967

IC50	8.44	Eur J Med Chem, (2018) 158:None:814	30248654

FLT3

Tclin

Receptor-type tyrosine-protein kinase FLT3

15 Activities

Items per page:

1 – 10 of 15

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	9.09	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	9.05	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	9.05	J. Med. Chem., (2013) 56:20:8032	24044867

Kd	8.85	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.82	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.7	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.59	Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	8.44	J Med Chem, (2016) 59:19:8712	27299736

IC50	8.44	Eur J Med Chem, (2016) 123:None:431	27490023

IC50	8.44	Bioorg Med Chem Lett, (2019) 29:19:126630	31466809

KIT

Tclin

Mast/stem cell growth factor receptor Kit

14 Activities

Items per page:

1 – 10 of 14

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.68	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.62	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.6	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.57	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.49	Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	8.4	Bioorg. Med. Chem., (2013) 21:17:5246	23838381

IC50	8.18	Bioorg Med Chem, (2019) 27:13:2801	31079967

IC50	8.17	Eur. J. Med. Chem., (2014) 87:None:508	25282672

IC50	8.17	Bioorg. Med. Chem., (2015) 23:15:4410	26169763

IC50	8.17	J Med Chem, (2016) 59:19:8712	27299736

MST1R

Tchem

Macrophage-stimulating protein receptor

8 Activities

Items per page:

1 – 8 of 8

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.52	Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	8.52	Eur. J. Med. Chem., (2016) 108:None:495	26717201

IC50	8.52	J Med Chem, (2016) 59:19:8712	27299736

IC50	8.52	Eur J Med Chem, (2016) 123:None:431	27490023

IC50	8.46	Eur. J. Med. Chem., (2014) 87:None:508	25282672

IC50	8.46	Bioorg. Med. Chem., (2015) 23:15:4410	26169763

IC50	8.46	Bioorg Med Chem, (2017) 25:16:4475	28716639

IC50	8.45	Bioorg Med Chem, (2019) 27:13:2801	31079967

FLT1

Tclin

Vascular endothelial growth factor receptor 1

6 Activities

Items per page:

1 – 6 of 6

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	9.1		23098265

IC50	9.1	J. Med. Chem., (2012) 55:24:10797	23098265

Kd	8.42	Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	8.17	Eur. J. Med. Chem., (2016) 108:None:495	26717201

IC50	8.17	J Med Chem, (2016) 59:19:8712	27299736

IC50	8.07	Bioorg Med Chem, (2019) 27:13:2801	31079967

FLT4

Tclin

Vascular endothelial growth factor receptor 3

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.55		23098265

Kd	8.82	Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	8.55	J. Med. Chem., (2012) 55:24:10797	23098265

IC50	8.55	Eur. J. Med. Chem., (2016) 108:None:495	26717201

IC50	8.55	J Med Chem, (2016) 59:19:8712	27299736

ABL1

Tclin

Tyrosine-protein kinase ABL1

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.4	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.25	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.75	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.7	Nat. Biotechnol., (2011) 29:11:1046	22037378

PDGFRA

Tclin

Platelet-derived growth factor receptor alpha

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.44	J Med Chem, (2016) 59:19:8712	27299736

IC50	8.44	Eur J Med Chem, (2016) 123:None:431	27490023

Kd	8.35	Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	8.34	Bioorg Med Chem, (2019) 27:13:2801	31079967

IC50	8.17	Bioorg Med Chem, (2017) 25:16:4475	28716639

ROS1

Tclin

Proto-oncogene tyrosine-protein kinase ROS

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	8.09	Eur J Med Chem, (2017) 134:None:348	28431340

IC50	8	Eur. J. Med. Chem., (2015) 90:None:195	25461320

Kd	7.85	Nat. Biotechnol., (2011) 29:11:1046	22037378

Ki	7.8	Eur J Med Chem, (2017) 134:None:348	28431340

Ki	7.7	Eur J Med Chem, (2017) 134:None:348	28431340

RET

Tclin

Proto-oncogene tyrosine-protein kinase receptor Ret

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	9.17	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	9.13	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.8	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.55	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.22	Science, (2017) 358:6367:None	29191878

PDGFRB

Tclin

Platelet-derived growth factor receptor beta

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	9.02	Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	8.03	Bioorg Med Chem, (2019) 27:13:2801	31079967

IC50	8.02	J Med Chem, (2016) 59:19:8712	27299736

IC50	8.02	Eur J Med Chem, (2016) 123:None:431	27490023

SRC

Tclin

Proto-oncogene tyrosine-protein kinase Src

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.7	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.55	Science, (2017) 358:6367:None	29191878

FRK

Tchem

Tyrosine-protein kinase FRK

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.42	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.55	Science, (2017) 358:6367:None	29191878

EPHA7

Tchem

Ephrin type-A receptor 7

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.6	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.3	Science, (2017) 358:6367:None	29191878

AXL

Tchem

Tyrosine-protein kinase receptor UFO

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	10.03	Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	7.96	J. Med. Chem., (2016) 59:8:3593	26555154

DDR1

Tchem

Epithelial discoidin domain-containing receptor 1

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	9.7	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	9.7	J. Med. Chem., (2015) 58:8:3287	25569119

SMO

Tclin

Smoothened homolog

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	7.22	J Med Chem, (2017) 60:17:7447	28787156

Ki	7.17	J Med Chem, (2017) 60:17:7447	28787156

TEK

Tclin

Angiopoietin-1 receptor

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.96	J Med Chem, (2016) 59:19:8712	27299736

Kd	8.51	Nat. Biotechnol., (2011) 29:11:1046	22037378

BLK

Tchem

Tyrosine-protein kinase Blk

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.27		Nat. Biotechnol., (2011) 29:11:1046	22037378

CSF1R

Tclin

Macrophage colony-stimulating factor 1 receptor

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.74		Nat. Biotechnol., (2011) 29:11:1046	22037378

LCK

Tclin

Tyrosine-protein kinase Lck

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.22		Nat. Biotechnol., (2011) 29:11:1046	22037378

EPHA2

Tclin

Ephrin type-A receptor 2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.44		Nat. Biotechnol., (2011) 29:11:1046	22037378

HCK

Tclin

Tyrosine-protein kinase HCK

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.82		Nat. Biotechnol., (2011) 29:11:1046	22037378

NTRK1

Tclin

High affinity nerve growth factor receptor

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.32		Nat. Biotechnol., (2011) 29:11:1046	22037378

MAP2K2

Tclin

Dual specificity mitogen-activated protein kinase kinase 2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.89		Nat. Biotechnol., (2011) 29:11:1046	22037378

CDK7

Tchem

Cyclin-dependent kinase 7

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.43		Nat. Biotechnol., (2011) 29:11:1046	22037378

LYN

Tclin

Tyrosine-protein kinase Lyn

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.04		Nat. Biotechnol., (2011) 29:11:1046	22037378

AURKC

Tchem

Aurora kinase C

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.92		Nat. Biotechnol., (2011) 29:11:1046	22037378

EPHB2

Tchem

Ephrin type-B receptor 2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.41		Nat. Biotechnol., (2011) 29:11:1046	22037378

MAP2K1

Tclin

Dual specificity mitogen-activated protein kinase kinase 1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.92		Nat. Biotechnol., (2011) 29:11:1046	22037378

STK10

Tchem

Serine/threonine-protein kinase 10

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	9.28		Nat. Biotechnol., (2011) 29:11:1046	22037378

EPHA5

Tchem

Ephrin type-A receptor 5

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.18		Nat. Biotechnol., (2011) 29:11:1046	22037378

EPHA4

Tchem

Ephrin type-A receptor 4

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.72		Nat. Biotechnol., (2011) 29:11:1046	22037378

ABL2

Tchem

Tyrosine-protein kinase ABL2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.57		Nat. Biotechnol., (2011) 29:11:1046	22037378

EPHA8

Tchem

Ephrin type-A receptor 8

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.74		Nat. Biotechnol., (2011) 29:11:1046	22037378

SLK

Tchem

STE20-like serine/threonine-protein kinase

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.52		Nat. Biotechnol., (2011) 29:11:1046	22037378

MKNK2

Tchem

MAP kinase-interacting serine/threonine-protein kinase 2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.43		Nat. Biotechnol., (2011) 29:11:1046	22037378

EPHA6

Tchem

Ephrin type-A receptor 6

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.96		Nat. Biotechnol., (2011) 29:11:1046	22037378

PTK6

Tchem

Protein-tyrosine kinase 6

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.37		Nat. Biotechnol., (2011) 29:11:1046	22037378

MAP4K5

Tchem

Mitogen-activated protein kinase kinase kinase kinase 5

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.4		Nat. Biotechnol., (2011) 29:11:1046	22037378

MAP2K5

Tchem