Pharos : Ligand Details

Target Activities

Items per page:

1 – 10 of 63

MET

Tclin

Hepatocyte growth factor receptor

35 Activities

Items per page:

1 – 10 of 35

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.85	Bioorg. Med. Chem., (2016) 24:4:812	26810712

IC50	7.85	Bioorg. Med. Chem., (2016) 24:8:1749	26964675

IC50	8.4	Eur J Med Chem, (2016) 120:None:37	27187857

IC50	8.49	Bioorg. Med. Chem., (2016) 24:16:3353	27068889

IC50	8.72	Bioorg. Med. Chem. Lett., (2016) 26:7:1680	26923692

IC50	8.73	Bioorg. Med. Chem., (2014) 22:4:1236	24485123

IC50	8.73	Bioorg. Med. Chem. Lett., (2016) 26:7:1794	26944614

IC50	8.73	Eur. J. Med. Chem., (2016) 119:None:96	27155466

IC50	8.75	Bioorg. Med. Chem., (2014) 22:22:6438	25438768

IC50	8.79	Bioorg. Med. Chem., (2015) 23:15:4410	26169763

KIT

Tclin

Mast/stem cell growth factor receptor Kit

12 Activities

Items per page:

1 – 10 of 12

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.02	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.12	Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	8.17	Eur. J. Med. Chem., (2014) 87:None:508	25282672

IC50	8.17	J Med Chem, (2016) 59:19:8712	27299736

IC50	8.17	Eur J Med Chem, (2016) 123:None:431	27490023

IC50	8.17	Bioorg. Med. Chem., (2015) 23:15:4410	26169763

IC50	8.4	Bioorg. Med. Chem., (2013) 21:17:5246	23838381

Kd	8.49	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.57	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.6	Nat. Biotechnol., (2011) 29:11:1046	22037378

FLT3

Tclin

Receptor-type tyrosine-protein kinase FLT3

12 Activities

Items per page:

1 – 10 of 12

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.96	Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	8.25	Eur. J. Med. Chem., (2014) 87:None:508	25282672

IC50	8.25	Bioorg. Med. Chem., (2015) 23:15:4410	26169763

IC50	8.44	J Med Chem, (2016) 59:19:8712	27299736

IC50	8.44	Eur J Med Chem, (2016) 123:None:431	27490023

Kd	8.59	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.7	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.82	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.85	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	9.05	Nat. Biotechnol., (2011) 29:11:1046	22037378

KDR

Tclin

Vascular endothelial growth factor receptor 2

11 Activities

Items per page:

1 – 10 of 11

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.8	J. Med. Chem., (2012) 55:24:10797	23098265

Kd	7.92	Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	8.17	J. Med. Chem., (2012) 55:24:10797	23098265

IC50	8.31	Eur. J. Med. Chem., (2014) 87:None:508	25282672

IC50	8.31	Bioorg. Med. Chem., (2015) 23:15:4410	26169763

IC50	9.05	J. Med. Chem., (2016) 59:8:3593	26555154

IC50	9.05	Bioorg. Med. Chem., (2016) 24:16:3353	27068889

IC50	9.05	Eur. J. Med. Chem., (2016) 108:None:495	26717201

IC50	9.07	J Med Chem, (2016) 59:19:8712	27299736

IC50	9.1	Eur. J. Med. Chem., (2013) 64:None:62	23644189

MST1R

Tchem

Macrophage-stimulating protein receptor

6 Activities

Items per page:

1 – 6 of 6

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.46	Eur. J. Med. Chem., (2014) 87:None:508	25282672

IC50	8.46	Bioorg. Med. Chem., (2015) 23:15:4410	26169763

Kd	8.52	Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	8.52	J Med Chem, (2016) 59:19:8712	27299736

IC50	8.52	Eur J Med Chem, (2016) 123:None:431	27490023

IC50	8.52	Eur. J. Med. Chem., (2016) 108:None:495	26717201

ABL1

Tclin

Tyrosine-protein kinase ABL1

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.7	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.75	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.25	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.4	Nat. Biotechnol., (2011) 29:11:1046	22037378

FLT1

Tclin

Vascular endothelial growth factor receptor 1

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.17	J Med Chem, (2016) 59:19:8712	27299736

IC50	8.17	Eur. J. Med. Chem., (2016) 108:None:495	26717201

Kd	8.42	Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	9.1	J. Med. Chem., (2012) 55:24:10797	23098265

IC50	9.10000038		23098265

FLT4

Tclin

Vascular endothelial growth factor receptor 3

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.55	J. Med. Chem., (2012) 55:24:10797	23098265

IC50	8.55	J Med Chem, (2016) 59:19:8712	27299736

IC50	8.55	Eur. J. Med. Chem., (2016) 108:None:495	26717201

Kd	8.82	Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	8.55000019		23098265

RET

Tclin

Proto-oncogene tyrosine-protein kinase receptor Ret

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.55	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.8	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	9.13	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	9.17	Nat. Biotechnol., (2011) 29:11:1046	22037378

PDGFRA

Tclin

Platelet-derived growth factor receptor alpha

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.35	Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	8.44	J Med Chem, (2016) 59:19:8712	27299736

IC50	8.44	Eur J Med Chem, (2016) 123:None:431	27490023