foretinib
Ligand Summary
Name: foretinib
PubChem: 42642645
Guide to Pharmacology: 5679
ChEMBL: CHEMBL1230609
LyCHI: J495KZAV9P7K
Target Activities
MET
Hepatocyte growth factor receptor
52 Activities
Items per page:
1 – 10 of 52
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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Kd | 8.85 | |||||
IC50 | 9.4 | Eur. J. Med. Chem., (2013) 64:None:62 | ||||
IC50 | 9.4 | Eur. J. Med. Chem., (2014) 80:None:254 | ||||
IC50 | 9.4 | Eur. J. Med. Chem., (2014) 83:None:581 | ||||
IC50 | 9.4 | Eur. J. Med. Chem., (2015) 90:None:195 | ||||
IC50 | 9.4 | Eur. J. Med. Chem., (2016) 108:None:495 | ||||
IC50 | 9.4 | J. Med. Chem., (2016) 59:8:3593 | ||||
IC50 | 9.4 | Bioorg. Med. Chem., (2016) 24:16:3353 | ||||
IC50 | 9.4 | J Med Chem, (2016) 59:19:8712 | ||||
IC50 | 9.4 | Eur J Med Chem, (2016) 123:None:431 | ||||
KDR
Vascular endothelial growth factor receptor 2
16 Activities
Items per page:
1 – 10 of 16
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 9.1 | Eur. J. Med. Chem., (2013) 64:None:62 | ||||
IC50 | 9.1 | Eur. J. Med. Chem., (2014) 83:None:581 | ||||
IC50 | 9.07 | J Med Chem, (2016) 59:19:8712 | ||||
IC50 | 9.07 | Eur J Med Chem, (2016) 123:None:431 | ||||
IC50 | 9.07 | Eur J Med Chem, (2018) 158:None:814 | ||||
IC50 | 9.05 | Eur. J. Med. Chem., (2016) 108:None:495 | ||||
IC50 | 9.05 | J. Med. Chem., (2016) 59:8:3593 | ||||
IC50 | 9.05 | Bioorg. Med. Chem., (2016) 24:16:3353 | ||||
IC50 | 8.82 | Bioorg Med Chem, (2019) 27:13:2801 | ||||
IC50 | 8.44 | Eur J Med Chem, (2018) 158:None:814 | ||||
FLT3
Receptor-type tyrosine-protein kinase FLT3
15 Activities
Items per page:
1 – 10 of 15
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 9.09 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 9.05 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 9.05 | J. Med. Chem., (2013) 56:20:8032 | ||||
Kd | 8.85 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.82 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.7 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.59 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
IC50 | 8.44 | J Med Chem, (2016) 59:19:8712 | ||||
IC50 | 8.44 | Eur J Med Chem, (2016) 123:None:431 | ||||
IC50 | 8.44 | Bioorg Med Chem Lett, (2019) 29:19:126630 | ||||
KIT
Mast/stem cell growth factor receptor Kit
14 Activities
Items per page:
1 – 10 of 14
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.68 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.62 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.6 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.57 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.49 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
IC50 | 8.4 | Bioorg. Med. Chem., (2013) 21:17:5246 | ||||
IC50 | 8.18 | Bioorg Med Chem, (2019) 27:13:2801 | ||||
IC50 | 8.17 | Eur. J. Med. Chem., (2014) 87:None:508 | ||||
IC50 | 8.17 | Bioorg. Med. Chem., (2015) 23:15:4410 | ||||
IC50 | 8.17 | J Med Chem, (2016) 59:19:8712 | ||||
MST1R
Macrophage-stimulating protein receptor
8 Activities
Items per page:
1 – 8 of 8
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.52 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
IC50 | 8.52 | Eur. J. Med. Chem., (2016) 108:None:495 | ||||
IC50 | 8.52 | J Med Chem, (2016) 59:19:8712 | ||||
IC50 | 8.52 | Eur J Med Chem, (2016) 123:None:431 | ||||
IC50 | 8.46 | Eur. J. Med. Chem., (2014) 87:None:508 | ||||
IC50 | 8.46 | Bioorg. Med. Chem., (2015) 23:15:4410 | ||||
IC50 | 8.46 | Bioorg Med Chem, (2017) 25:16:4475 | ||||
IC50 | 8.45 | Bioorg Med Chem, (2019) 27:13:2801 | ||||
FLT1
Vascular endothelial growth factor receptor 1
6 Activities
Items per page:
1 – 6 of 6
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 9.1 | |||||
IC50 | 9.1 | J. Med. Chem., (2012) 55:24:10797 | ||||
Kd | 8.42 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
IC50 | 8.17 | Eur. J. Med. Chem., (2016) 108:None:495 | ||||
IC50 | 8.17 | J Med Chem, (2016) 59:19:8712 | ||||
IC50 | 8.07 | Bioorg Med Chem, (2019) 27:13:2801 | ||||
FLT4
Vascular endothelial growth factor receptor 3
5 Activities
Items per page:
1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 8.55 | |||||
Kd | 8.82 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
IC50 | 8.55 | J. Med. Chem., (2012) 55:24:10797 | ||||
IC50 | 8.55 | Eur. J. Med. Chem., (2016) 108:None:495 | ||||
IC50 | 8.55 | J Med Chem, (2016) 59:19:8712 | ||||
ABL1
Tyrosine-protein kinase ABL1
5 Activities
Items per page:
1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.4 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.25 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 7.75 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 7.7 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
PDGFRA
Platelet-derived growth factor receptor alpha
5 Activities
Items per page:
1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 8.44 | J Med Chem, (2016) 59:19:8712 | ||||
IC50 | 8.44 | Eur J Med Chem, (2016) 123:None:431 | ||||
Kd | 8.35 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
IC50 | 8.34 | Bioorg Med Chem, (2019) 27:13:2801 | ||||
IC50 | 8.17 | Bioorg Med Chem, (2017) 25:16:4475 | ||||
ROS1
Proto-oncogene tyrosine-protein kinase ROS
5 Activities
Items per page:
1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 8.09 | Eur J Med Chem, (2017) 134:None:348 | ||||
IC50 | 8 | Eur. J. Med. Chem., (2015) 90:None:195 | ||||
Kd | 7.85 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Ki | 7.8 | Eur J Med Chem, (2017) 134:None:348 | ||||
Ki | 7.7 | Eur J Med Chem, (2017) 134:None:348 | ||||
RET
Proto-oncogene tyrosine-protein kinase receptor Ret
5 Activities
Items per page:
1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 9.17 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 9.13 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.8 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.55 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.22 | Science, (2017) 358:6367:None | ||||
PDGFRB
Platelet-derived growth factor receptor beta
4 Activities
Items per page:
1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 9.02 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
IC50 | 8.03 | Bioorg Med Chem, (2019) 27:13:2801 | ||||
IC50 | 8.02 | J Med Chem, (2016) 59:19:8712 | ||||
IC50 | 8.02 | Eur J Med Chem, (2016) 123:None:431 | ||||
SRC
Proto-oncogene tyrosine-protein kinase Src
2 Activities
FRK
Tyrosine-protein kinase FRK
2 Activities
EPHA7
Ephrin type-A receptor 7
2 Activities
AXL
Tyrosine-protein kinase receptor UFO
2 Activities
DDR1
Epithelial discoidin domain-containing receptor 1
2 Activities
SMO
Smoothened homolog
2 Activities
TEK
Angiopoietin-1 receptor
2 Activities
BLK
Tyrosine-protein kinase Blk
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.27 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
CSF1R
Macrophage colony-stimulating factor 1 receptor
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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Kd | 8.74 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
LCK
Tyrosine-protein kinase Lck
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.22 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
EPHA2
Ephrin type-A receptor 2
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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Kd | 8.44 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
HCK
Tyrosine-protein kinase HCK
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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Kd | 7.82 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
NTRK1
High affinity nerve growth factor receptor
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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Kd | 8.32 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
MAP2K2
Dual specificity mitogen-activated protein kinase kinase 2
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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Kd | 7.89 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
CDK7
Cyclin-dependent kinase 7
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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Kd | 8.43 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
LYN
Tyrosine-protein kinase Lyn
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.04 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
AURKC
Aurora kinase C
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.92 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
EPHB2
Ephrin type-B receptor 2
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.41 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
MAP2K1
Dual specificity mitogen-activated protein kinase kinase 1
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.92 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
STK10
Serine/threonine-protein kinase 10
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 9.28 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
EPHA5
Ephrin type-A receptor 5
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.18 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
EPHA4
Ephrin type-A receptor 4
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.72 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
ABL2
Tyrosine-protein kinase ABL2
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.57 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
EPHA8
Ephrin type-A receptor 8
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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Kd | 8.74 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
SLK
STE20-like serine/threonine-protein kinase
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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Kd | 8.52 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
MKNK2
MAP kinase-interacting serine/threonine-protein kinase 2
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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Kd | 8.43 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
EPHA6
Ephrin type-A receptor 6
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.96 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
PTK6
Protein-tyrosine kinase 6
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.37 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
MAP4K5
Mitogen-activated protein kinase kinase kinase kinase 5
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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Kd | 8.4 | Nat. Biotechnol., (2011) 29:11:1046 | ||||