Pharos : Ligand Details - HR8JDR1DN75X

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Ligand Summary

Ligand Structure

Rendered image for the query structure

Synonyms & Links

Name: phlorizin

PubChem: 6072

Guide to Pharmacology: 4757

ChEMBL: CHEMBL245067

LyCHI: HR8JDR1DN75X

Target Activities

Explore Associated and Predicted Targets

SLC5A2

Tclin

Sodium/glucose cotransporter 2

21 Activities

Items per page:

1 – 10 of 21

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.8		Bioorg. Med. Chem., (2012) 20:13:4117	22652255

IC50	7.79		J. Med. Chem., (2012) 55:17:7828	22889351

Ki	7.73		J. Med. Chem., (2009) 52:7:1785	19243175

IC50	7.56		J. Med. Chem., (2010) 53:8:3247	20302302

EC50	7.46		Bioorg. Med. Chem. Lett., (2008) 18:17:4770	18707880

EC50	7.46		J. Med. Chem., (2009) 52:7:1785	19243175

IC50	7.46		Eur J Med Chem, (2019) 184:None:111773	31630053

IC50	7.46		Bioorg Med Chem Lett, (2020) 30:17:127387	32738984

EC50	7.45		J. Med. Chem., (2008) 51:5:1145	18260618

IC50	7.44		Bioorg. Med. Chem. Lett., (2011) 21:8:2472	21398124

SLC5A1

Tclin

Sodium/glucose cotransporter 1

18 Activities

Items per page:

1 – 10 of 18

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.22		Bioorg. Med. Chem. Lett., (2014) 24:6:1528	24556379

EC50	6.92		Bioorg. Med. Chem., (2013) 21:21:6282	24071445

EC50	6.82		Bioorg. Med. Chem., (2016) 24:10:2242	27075813

Ki	6.75		J. Med. Chem., (2000) 43:9:1692	10794686

IC50	6.73		J. Med. Chem., (2012) 55:17:7828	22889351

IC50	6.72		Bioorg. Med. Chem., (2011) 19:18:5334	21873071

IC50	6.72		Bioorg. Med. Chem., (2012) 20:13:4117	22652255

EC50	6.71		J. Med. Chem., (2011) 54:1:166	21128592

IC50	6.7		Bioorg. Med. Chem., (2007) 15:10:3445	17374486

IC50	6.68		J. Med. Chem., (2009) 52:20:6201	19785435

SLC5A11

Tchem

Sodium/myo-inositol cotransporter 2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	4.1			12133831

SLC5A4

Tchem

Solute carrier family 5 member 4

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.8		Bioorg. Med. Chem., (2011) 19:18:5334	21873071