Pharos : Ligand Details - HR8JDR1DN75X

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Ligand Summary

Ligand Structure

chemical structure image

Synonyms & Links

Name: Phlorizin

PubChem: 6072

Guide to Pharmacology: 4757

ChEMBL: CHEMBL245067

LyCHI: HR8JDR1DN75X

Target Activities

SLC5A2

Tclin

Sodium/glucose cotransporter 2

16 Activities

Items per page:

1 – 10 of 16

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.12		Bioorg. Med. Chem. Lett., (2008) 18:18:4944	18755586

EC50	6.8		Bioorg. Med. Chem. Lett., (2008) 18:17:4770	18707880

EC50	6.91		Bioorg. Med. Chem., (2016) 24:10:2242	27075813

EC50	6.97		J. Med. Chem., (2011) 54:1:166	21128592

IC50	7		Bioorg. Med. Chem., (2007) 15:10:3445	17374486

EC50	7.11		Bioorg. Med. Chem., (2013) 21:21:6282	24071445

IC50	7.23		Bioorg. Med. Chem. Lett., (2014) 24:6:1528	24556379

IC50	7.42		Bioorg. Med. Chem., (2012) 20:22:6598	23062824

IC50	7.44		Bioorg. Med. Chem. Lett., (2011) 21:8:2472	21398124

EC50	7.45		J. Med. Chem., (2008) 51:5:1145	18260618

SLC5A1

Tclin

Sodium/glucose cotransporter 1

14 Activities

Items per page:

1 – 10 of 14

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.27		Bioorg. Med. Chem., (2012) 20:22:6598	23062824

IC50	6.48		Bioorg. Med. Chem. Lett., (2011) 21:8:2472	21398124

EC50	6.48		J. Med. Chem., (2008) 51:5:1145	18260618

IC50	6.61		J. Med. Chem., (2010) 53:8:3247	20302302

IC50	6.68		J. Med. Chem., (2009) 52:20:6201	19785435

IC50	6.7		Bioorg. Med. Chem., (2007) 15:10:3445	17374486

EC50	6.71		J. Med. Chem., (2011) 54:1:166	21128592

IC50	6.72		Bioorg. Med. Chem., (2011) 19:18:5334	21873071

IC50	6.72		Bioorg. Med. Chem., (2012) 20:13:4117	22652255

IC50	6.73		J. Med. Chem., (2012) 55:17:7828	22889351

SLC5A4

Tchem

Solute carrier family 5 member 4

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.8		Bioorg. Med. Chem., (2011) 19:18:5334	21873071

SLC5A11

Tchem

Sodium/myo-inositol cotransporter 2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	4.0999999			12133831