Pharos : Ligand Details - HMDNJV6YP9YD

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Ligand Summary

Ligand Structure

Rendered image for the query structure

Synonyms & Links

Name: Linsitinib

ChEMBL: CHEMBL1091644

LyCHI: HMDNJV6YP9YD

Target Activities

Explore Associated and Predicted Targets

IGF1R

Tclin

Insulin-like growth factor 1 receptor

9 Activities

Items per page:

1 – 9 of 9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8.7		Eur. J. Med. Chem., (2015) 92:None:246	25559205

IC50	8.55		Bioorg. Med. Chem. Lett., (2016) 26:8:2057	26951753

IC50	8.12		Bioorg. Med. Chem. Lett., (2016) 26:8:2057	26951753

IC50	7.92		ACS Med. Chem. Lett., (2013) 4:7:627	24900721

IC50	7.89		ACS Med. Chem. Lett., (2013) 4:7:627	24900721

IC50	7.85		Bioorg. Med. Chem. Lett., (2016) 26:8:2057	26951753

IC50	7.75		Bioorg. Med. Chem. Lett., (2010) 20:8:2452	20346655

IC50	7.62		Bioorg. Med. Chem. Lett., (2011) 21:4:1176	21251824

IC50	7.62		ACS Med. Chem. Lett., (2013) 4:7:627	24900721

INSR

Tclin

Insulin receptor

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.8		Bioorg. Med. Chem. Lett., (2016) 26:8:2057	26951753

IC50	7.75		ACS Med. Chem. Lett., (2014) 5:4:298	24900830

MAPK11

Tchem

Mitogen-activated protein kinase 11

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8		Science, (2017) 358:6367:None	29191878

ABCG2

Tchem

ATP-binding cassette sub-family G member 2

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
EC50	6.98		Eur J Med Chem, (2019) 164:None:193	30594677