Pharos : Ligand Details

Target Activities

Explore Associated and Predicted Targets

AURKA

Tchem

Aurora kinase A

14 Activities

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1 – 10 of 14

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.89		17125279

Kd	8.67	None, None:None:None

Ki	8.6	J. Med. Chem., (2006) 49:24:7247	17125279

Kd	8.57	None, None:None:None

Kd	8.47	None, None:None:None

Kd	8.43	None, None:None:None

Kd	8.4	None, None:None:None

Kd	8.01	None, None:None:None

Kd	7.96	Science, (2017) 358:6367:None	29191878

IC50	7.89	J. Med. Chem., (2006) 49:24:7247	17125279

ABL1

Tclin

Tyrosine-protein kinase ABL1

4 Activities

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1 – 4 of 4

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.3	J. Med. Chem., (2010) 53:15:5439	20604564

IC50	8.1	J. Med. Chem., (2013) 56:17:6991	23937569

Kd	7.62	Science, (2017) 358:6367:None	29191878

IC50	7.6	J. Med. Chem., (2006) 49:24:7247	17125279

AURKB

Tchem

Aurora kinase B

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.1			17125279

AURKC

Tchem

Aurora kinase C

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.21			17125279

SLK

Tchem

STE20-like serine/threonine-protein kinase

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.21			17125279

PRKAG2

Tchem

5'-AMP-activated protein kinase subunit gamma-2

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.03		Science, (2017) 358:6367:None	29191878

FYN

Tclin

Tyrosine-protein kinase Fyn

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.62		Science, (2017) 358:6367:None	29191878

EPHA2

Tclin

Ephrin type-A receptor 2

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.62		Science, (2017) 358:6367:None	29191878

ABL2

Tchem

Tyrosine-protein kinase ABL2

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8		Science, (2017) 358:6367:None	29191878

BCR

Tclin

Breakpoint cluster region protein

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.3		Science, (2017) 358:6367:None	29191878

NUAK2

Tchem

NUAK family SNF1-like kinase 2

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.6		Science, (2017) 358:6367:None	29191878

ERCC2

Tchem

General transcription and DNA repair factor IIH helicase subunit XPD

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	6.87		Science, (2017) 358:6367:None	29191878

RET

Tclin

Proto-oncogene tyrosine-protein kinase receptor Ret

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.22		Science, (2017) 358:6367:None	29191878

PLK4

Tchem

Serine/threonine-protein kinase PLK4

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.3		Science, (2017) 358:6367:None	29191878

EPHB4

Tchem

Ephrin type-B receptor 4

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.75		Science, (2017) 358:6367:None	29191878