Pharos : Ligand Details

Target Activities

Explore Associated and Predicted Targets

ABL1

Tclin

Tyrosine-protein kinase ABL1

18 Activities

Items per page:

1 – 10 of 18

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	9.17	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	9.11	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	9.03	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.72	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.64	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	8.59	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.55	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.3	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	8.25	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	8.21	Nat. Biotechnol., (2008) 26:1:127	18183025

FLT3

Tclin

Receptor-type tyrosine-protein kinase FLT3

16 Activities

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1 – 10 of 16

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	6.92		18820131

IC50	6.28		17638907

Kd	9.1		22037378

Kd	9.29	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	9.13	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	9.1	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	9.1	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.64	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	8.64	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.31	Nat. Biotechnol., (2008) 26:1:127	18183025

KIT

Tclin

Mast/stem cell growth factor receptor Kit

10 Activities

Items per page:

1 – 10 of 10

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	6.3		17638907

Kd	8.68	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.36	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.3	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	8.3	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.27	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	8.27	Eur. J. Med. Chem., (2011) 46:6:2043	21429632

Kd	8.27	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	7.75	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	7.75	Nat. Biotechnol., (2011) 29:11:1046	22037378

RET

Tclin

Proto-oncogene tyrosine-protein kinase receptor Ret

8 Activities

Items per page:

1 – 8 of 8

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	6.06		17638907

Kd	8.49	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.37	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.35	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	8.35	Nat. Biotechnol., (2011) 29:11:1046	22037378

Ki	8.2	None, None:None:None

Kd	7.77	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	7.77	Nat. Biotechnol., (2011) 29:11:1046	22037378

MKNK2

Tchem

MAP kinase-interacting serine/threonine-protein kinase 2

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.52	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	8.52	Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	7.7	J. Med. Chem., (2016) 59:7:3063	27011159

IC50	7.7	J Med Chem, (2020) 63:2:621	31910010

PDGFRB

Tclin

Platelet-derived growth factor receptor beta

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	8.1	None, None:None:None

Kd	8.09	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	8.09	Nat. Biotechnol., (2011) 29:11:1046	22037378

LCK

Tclin

Tyrosine-protein kinase Lck

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.96	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	7.96	Nat. Biotechnol., (2011) 29:11:1046	22037378

Ki	7.8	None, None:None:None

CDK8

Tchem

Cyclin-dependent kinase 8

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.85	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	8.85	Nat. Biotechnol., (2011) 29:11:1046	22037378

Ki	8.5	None, None:None:None

KDR

Tclin

Vascular endothelial growth factor receptor 2

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	6.77		17638907

Ki	8.6	None, None:None:None

CSF1R

Tclin

Macrophage colony-stimulating factor 1 receptor

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.24	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	8.24	Nat. Biotechnol., (2011) 29:11:1046	22037378

PDGFRA

Tclin

Platelet-derived growth factor receptor alpha

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.57	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	7.57	Nat. Biotechnol., (2011) 29:11:1046	22037378

CDK7

Tchem

Cyclin-dependent kinase 7

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.35	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	8.34	Nat. Biotechnol., (2011) 29:11:1046	22037378

MAP3K20

Tchem

Mitogen-activated protein kinase kinase kinase 20

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.64	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	8.64	Nat. Biotechnol., (2011) 29:11:1046	22037378

LYN

Tclin

Tyrosine-protein kinase Lyn

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.85	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	7.85	Nat. Biotechnol., (2011) 29:11:1046	22037378

STK10

Tchem

Serine/threonine-protein kinase 10

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	9.04	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	9.04	Nat. Biotechnol., (2011) 29:11:1046	22037378

ABL2

Tchem

Tyrosine-protein kinase ABL2

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.47	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	8.47	Nat. Biotechnol., (2011) 29:11:1046	22037378

EPHA8

Tchem

Ephrin type-A receptor 8

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.75	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	7.75	Nat. Biotechnol., (2011) 29:11:1046	22037378

SLK

Tchem

STE20-like serine/threonine-protein kinase

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.64	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	7.64	Nat. Biotechnol., (2011) 29:11:1046	22037378

FRK

Tchem

Tyrosine-protein kinase FRK

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.58	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	7.58	Nat. Biotechnol., (2011) 29:11:1046	22037378

MAPK12

Tchem

Mitogen-activated protein kinase 12

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.54	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	7.54	Nat. Biotechnol., (2011) 29:11:1046	22037378

MKNK1

Tchem

MAP kinase-interacting serine/threonine-protein kinase 1

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.58	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	7.58	Nat. Biotechnol., (2011) 29:11:1046	22037378

DDR2

Tchem

Discoidin domain-containing receptor 2

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.96	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	7.96	Nat. Biotechnol., (2011) 29:11:1046	22037378

TIE1

Tchem

Tyrosine-protein kinase receptor Tie-1

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	9.54	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	9.54	Nat. Biotechnol., (2011) 29:11:1046	22037378

DDR1

Tchem

Epithelial discoidin domain-containing receptor 1

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	9.16	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	9.16	Nat. Biotechnol., (2011) 29:11:1046	22037378

CDK17

Tchem

Cyclin-dependent kinase 17

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.82	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	7.82	Nat. Biotechnol., (2011) 29:11:1046	22037378

MUSK

Tchem

Muscle, skeletal receptor tyrosine-protein kinase

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.51	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	8.51	Nat. Biotechnol., (2011) 29:11:1046	22037378

CDK19

Tchem

Cyclin-dependent kinase 19

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	8.82	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	8.82	Nat. Biotechnol., (2011) 29:11:1046	22037378

CDK14

Tchem

Cyclin-dependent kinase 14

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.77	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	7.77	Nat. Biotechnol., (2011) 29:11:1046	22037378

MAP4K4

Tchem

Mitogen-activated protein kinase kinase kinase kinase 4

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.82	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	7.82	Nat. Biotechnol., (2011) 29:11:1046	22037378

TEK

Tclin

Angiopoietin-1 receptor

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Kd	7.72	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	7.72	Nat. Biotechnol., (2011) 29:11:1046	22037378

MAPK13

Tchem

Mitogen-activated protein kinase 13

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.89		Nat. Biotechnol., (2011) 29:11:1046	22037378

MAP2K7

Tchem

Dual specificity mitogen-activated protein kinase kinase 7

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.57		Nat. Biotechnol., (2011) 29:11:1046	22037378

HIPK2

Tchem

Homeodomain-interacting protein kinase 2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.14		Nat. Biotechnol., (2011) 29:11:1046	22037378

HIPK3

Tchem

Homeodomain-interacting protein kinase 3

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.4		Nat. Biotechnol., (2011) 29:11:1046	22037378

MAPK14

Tchem

Mitogen-activated protein kinase 14

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8		None, None:None:None

TAOK1

Tchem

Serine/threonine-protein kinase TAO1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.54		Nat. Biotechnol., (2011) 29:11:1046	22037378

MINK1

Tchem

Misshapen-like kinase 1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.11		Nat. Biotechnol., (2011) 29:11:1046	22037378

MAP3K7

Tchem

Mitogen-activated protein kinase kinase kinase 7

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.82		Nat. Biotechnol., (2011) 29:11:1046	22037378

CDKL1

Tchem

Cyclin-dependent kinase-like 1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.89		Nat. Biotechnol., (2011) 29:11:1046	22037378

TAOK3

Tchem

Serine/threonine-protein kinase TAO3

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.24		Nat. Biotechnol., (2011) 29:11:1046	22037378

CDKL2

Tchem

Cyclin-dependent kinase-like 2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	9.28		Nat. Biotechnol., (2011) 29:11:1046	22037378

CDKL3

Tchem

Cyclin-dependent kinase-like 3

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.41		Nat. Biotechnol., (2011) 29:11:1046	22037378

CDKL5

Tchem

Cyclin-dependent kinase-like 5

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.18		Nat. Biotechnol., (2011) 29:11:1046	22037378

CDK13

Tchem

Cyclin-dependent kinase 13

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	9.03		Nat. Biotechnol., (2011) 29:11:1046	22037378

STK35

Tchem

Serine/threonine-protein kinase 35

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.8		Nat. Biotechnol., (2011) 29:11:1046	22037378

HIPK4

Tchem

Homeodomain-interacting protein kinase 4

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	8.41		Nat. Biotechnol., (2011) 29:11:1046	22037378