AST-487
Ligand Summary
Name: AST-487
PubChem: 11409972
Guide to Pharmacology: 5661
ChEMBL: CHEMBL574738
LyCHI: HJKNQGK5SMHN
Target Activities
ABL1
Tyrosine-protein kinase ABL1
18 Activities
Items per page:
1 – 10 of 18
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 9.17 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 9.11 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 9.03 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.72 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.64 | Nat. Biotechnol., (2008) 26:1:127 | ||||
Kd | 8.59 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.55 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.3 | Nat. Biotechnol., (2008) 26:1:127 | ||||
Kd | 8.25 | Nat. Biotechnol., (2008) 26:1:127 | ||||
Kd | 8.21 | Nat. Biotechnol., (2008) 26:1:127 | ||||
FLT3
Receptor-type tyrosine-protein kinase FLT3
16 Activities
Items per page:
1 – 10 of 16
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 6.92 | |||||
IC50 | 6.28 | |||||
Kd | 9.1 | |||||
Kd | 9.29 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 9.13 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 9.1 | Nat. Biotechnol., (2008) 26:1:127 | ||||
Kd | 9.1 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.64 | Nat. Biotechnol., (2008) 26:1:127 | ||||
Kd | 8.64 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.31 | Nat. Biotechnol., (2008) 26:1:127 | ||||
KIT
Mast/stem cell growth factor receptor Kit
10 Activities
Items per page:
1 – 10 of 10
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 6.3 | |||||
Kd | 8.68 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.36 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.3 | Nat. Biotechnol., (2008) 26:1:127 | ||||
Kd | 8.3 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.27 | Nat. Biotechnol., (2008) 26:1:127 | ||||
Kd | 8.27 | Eur. J. Med. Chem., (2011) 46:6:2043 | ||||
Kd | 8.27 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 7.75 | Nat. Biotechnol., (2008) 26:1:127 | ||||
Kd | 7.75 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
RET
Proto-oncogene tyrosine-protein kinase receptor Ret
8 Activities
Items per page:
1 – 8 of 8
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 6.06 | |||||
Kd | 8.49 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.37 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.35 | Nat. Biotechnol., (2008) 26:1:127 | ||||
Kd | 8.35 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Ki | 8.2 | None, None:None:None | ||||
Kd | 7.77 | Nat. Biotechnol., (2008) 26:1:127 | ||||
Kd | 7.77 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
MKNK2
MAP kinase-interacting serine/threonine-protein kinase 2
4 Activities
Items per page:
1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.52 | Nat. Biotechnol., (2008) 26:1:127 | ||||
Kd | 8.52 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
IC50 | 7.7 | J. Med. Chem., (2016) 59:7:3063 | ||||
IC50 | 7.7 | J Med Chem, (2020) 63:2:621 | ||||
PDGFRB
Platelet-derived growth factor receptor beta
3 Activities
LCK
Tyrosine-protein kinase Lck
3 Activities
CDK8
Cyclin-dependent kinase 8
3 Activities
KDR
Vascular endothelial growth factor receptor 2
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 6.77 | |||||
Ki | 8.6 | None, None:None:None | ||||
CSF1R
Macrophage colony-stimulating factor 1 receptor
2 Activities
PDGFRA
Platelet-derived growth factor receptor alpha
2 Activities
CDK7
Cyclin-dependent kinase 7
2 Activities
MAP3K20
Mitogen-activated protein kinase kinase kinase 20
2 Activities
LYN
Tyrosine-protein kinase Lyn
2 Activities
STK10
Serine/threonine-protein kinase 10
2 Activities
ABL2
Tyrosine-protein kinase ABL2
2 Activities
EPHA8
Ephrin type-A receptor 8
2 Activities
SLK
STE20-like serine/threonine-protein kinase
2 Activities
FRK
Tyrosine-protein kinase FRK
2 Activities
MAPK12
Mitogen-activated protein kinase 12
2 Activities
MKNK1
MAP kinase-interacting serine/threonine-protein kinase 1
2 Activities
DDR2
Discoidin domain-containing receptor 2
2 Activities
TIE1
Tyrosine-protein kinase receptor Tie-1
2 Activities
DDR1
Epithelial discoidin domain-containing receptor 1
2 Activities
CDK17
Cyclin-dependent kinase 17
2 Activities
MUSK
Muscle, skeletal receptor tyrosine-protein kinase
2 Activities
CDK19
Cyclin-dependent kinase 19
2 Activities
CDK14
Cyclin-dependent kinase 14
2 Activities
MAP4K4
Mitogen-activated protein kinase kinase kinase kinase 4
2 Activities
TEK
Angiopoietin-1 receptor
2 Activities
MAPK13
Mitogen-activated protein kinase 13
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.89 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
MAP2K7
Dual specificity mitogen-activated protein kinase kinase 7
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.57 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
HIPK2
Homeodomain-interacting protein kinase 2
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.14 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
HIPK3
Homeodomain-interacting protein kinase 3
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.4 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
MAPK14
Mitogen-activated protein kinase 14
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 8 | None, None:None:None | ||||
TAOK1
Serine/threonine-protein kinase TAO1
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.54 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
MINK1
Misshapen-like kinase 1
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.11 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
MAP3K7
Mitogen-activated protein kinase kinase kinase 7
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.82 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
CDKL1
Cyclin-dependent kinase-like 1
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.89 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
TAOK3
Serine/threonine-protein kinase TAO3
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.24 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
CDKL2
Cyclin-dependent kinase-like 2
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 9.28 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
CDKL3
Cyclin-dependent kinase-like 3
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.41 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
CDKL5
Cyclin-dependent kinase-like 5
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.18 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
CDK13
Cyclin-dependent kinase 13
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 9.03 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
STK35
Serine/threonine-protein kinase 35
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.8 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
HIPK4
Homeodomain-interacting protein kinase 4
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 8.41 | Nat. Biotechnol., (2011) 29:11:1046 | ||||