CHEMBL574738
Ligand Summary
Name: AST-487
PubChem: 11409972
Guide to Pharmacology: 5661
ChEMBL: CHEMBL574738
LyCHI: HJKNQGK5SMHN
Target Activities
ABL1
Tyrosine-protein kinase ABL1
17 Activities
Items per page:
1 – 10 of 17
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 7.6 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 7.64 | Nat. Biotechnol., (2008) 26:1:127 | ||||
Kd | 7.89 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 7.89 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 7.89 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.08 | Nat. Biotechnol., (2008) 26:1:127 | ||||
Kd | 8.21 | Nat. Biotechnol., (2008) 26:1:127 | ||||
Kd | 8.25 | Nat. Biotechnol., (2008) 26:1:127 | ||||
Kd | 8.3 | Nat. Biotechnol., (2008) 26:1:127 | ||||
FLT3
Receptor-type tyrosine-protein kinase FLT3
16 Activities
Items per page:
1 – 10 of 16
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 7.96 | Nat. Biotechnol., (2008) 26:1:127 | ||||
Kd | 7.96 | Nat. Biotechnol., (2008) 26:1:127 | ||||
Kd | 7.96 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 7.96 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
IC50 | 8.3 | J. Med. Chem., (2013) 56:17:6991 | ||||
Kd | 8.31 | Nat. Biotechnol., (2008) 26:1:127 | ||||
Kd | 8.31 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.64 | Nat. Biotechnol., (2008) 26:1:127 | ||||
Kd | 8.64 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 9.1 | Nat. Biotechnol., (2008) 26:1:127 | ||||
KIT
Mast/stem cell growth factor receptor Kit
10 Activities
Items per page:
1 – 10 of 10
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 7.75 | Nat. Biotechnol., (2008) 26:1:127 | ||||
Kd | 7.75 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.27 | Eur. J. Med. Chem., (2011) 46:6:2043 | ||||
Kd | 8.27 | Nat. Biotechnol., (2008) 26:1:127 | ||||
Kd | 8.27 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.3 | Nat. Biotechnol., (2008) 26:1:127 | ||||
Kd | 8.3 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.36 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.68 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
IC50 | 6.30000019 | |||||
RET
Proto-oncogene tyrosine-protein kinase receptor Ret
7 Activities
Items per page:
1 – 7 of 7
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 7.77 | Nat. Biotechnol., (2008) 26:1:127 | ||||
Kd | 7.77 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.35 | Nat. Biotechnol., (2008) 26:1:127 | ||||
Kd | 8.35 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.37 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
Kd | 8.49 | Nat. Biotechnol., (2011) 29:11:1046 | ||||
IC50 | 6.05999994 | |||||
MKNK2
MAP kinase-interacting serine/threonine-protein kinase 2
3 Activities
CDK17
Cyclin-dependent kinase 17
2 Activities
CDK19
Cyclin-dependent kinase 19
2 Activities
CSF1R
Macrophage colony-stimulating factor 1 receptor
2 Activities
DDR1
Epithelial discoidin domain-containing receptor 1
2 Activities
STK10
Serine/threonine-protein kinase 10
2 Activities
LYN
Tyrosine-protein kinase Lyn
2 Activities
CDK7
Cyclin-dependent kinase 7
2 Activities
TIE1
Tyrosine-protein kinase receptor Tie-1
2 Activities
CDK14
Cyclin-dependent kinase 14
2 Activities
EPHA8
Ephrin type-A receptor 8
2 Activities
ABL2
Tyrosine-protein kinase ABL2
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|---|---|---|---|
Kd | 8.47 | Nat. Biotechnol., (2008) 26:1:127 |