Pharos : Ligand Details

Target Activities

ABL1

Tclin

Tyrosine-protein kinase ABL1

5 Activities

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1 – 5 of 5

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.73999977		18849971

IC50	8.7	Nat. Chem. Biol., (2008) 4:11:691	18849971

Ki	7.8	None, None:None:None

IC50	7.75	Nat. Chem. Biol., (2008) 4:11:691	18849971

IC50	7.75	MedChemComm, (2012) 3:11:1337

KDR

Tclin

Vascular endothelial growth factor receptor 2

4 Activities

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1 – 4 of 4

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.92000008		18849971

Ki	8.3	None, None:None:None

IC50	7.92	J. Med. Chem., (2010) 53:4:1413	20166671

IC50	7.92	Nat. Chem. Biol., (2008) 4:11:691	18849971

SRC

Tclin

Proto-oncogene tyrosine-protein kinase Src

4 Activities

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1 – 4 of 4

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.8499999		18849971

IC50	7.85	J. Med. Chem., (2010) 53:4:1413	20166671

IC50	7.85	Nat. Chem. Biol., (2008) 4:11:691	18849971

IC50	7.85	MedChemComm, (2012) 3:11:1337

HCK

Tclin

Tyrosine-protein kinase HCK

3 Activities

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1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.10000038		18849971

IC50	8.1	Nat. Chem. Biol., (2008) 4:11:691	18849971

IC50	8.1	MedChemComm, (2012) 3:11:1337

MTOR

Tclin

Serine/threonine-protein kinase mTOR

3 Activities

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1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8		18849971

IC50	8	J. Med. Chem., (2010) 53:4:1413	20166671

IC50	8	MedChemComm, (2012) 3:11:1337

EGFR

Tclin

Epidermal growth factor receptor

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.59000015			18849971

PIK3CA

Tclin

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.28000021			18849971

PIK3CB

Tchem

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	5.8499999			18849971

PIK3CD

Tclin

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.82000017			18849971

PIK3CG

Tclin

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	5.96000004			18849971

PDGFRA

Tclin

Platelet-derived growth factor receptor alpha

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8.69999981			18849971

PRKDC

Tchem

DNA-dependent protein kinase catalytic subunit

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.21999979			18849971

RET

Tclin

Proto-oncogene tyrosine-protein kinase receptor Ret

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.9		None, None:None:None