CHEMBL4569508
Ligand Summary
Name: 4-(6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)-N-(2,2,2-trifluoroethyl)thiophene-2-carboxamide
PubChem: 24759534
ChEMBL: CHEMBL4569508
LyCHI: G29XKGDU9DDJ
Target Activities
SGK1
Serine/threonine-protein kinase Sgk1
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.57 | Bioorg Med Chem Lett, (2016) 26:17:4362 | ||||
CDK2
Cyclin-dependent kinase 2
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 7.92 | Bioorg Med Chem Lett, (2016) 26:17:4362 | ||||
LCK
Tyrosine-protein kinase Lck
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.72 | Bioorg Med Chem Lett, (2016) 26:17:4362 | ||||
EPHA8
Ephrin type-A receptor 8
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 7.68 | Bioorg Med Chem Lett, (2016) 26:17:4362 | ||||
MINK1
Misshapen-like kinase 1
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.89 | Bioorg Med Chem Lett, (2016) 26:17:4362 | ||||
NUAK1
NUAK family SNF1-like kinase 1
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 7.82 | Bioorg Med Chem Lett, (2016) 26:17:4362 | ||||
MARK3
MAP/microtubule affinity-regulating kinase 3
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 9 | Bioorg Med Chem Lett, (2016) 26:17:4362 | ||||
LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 7.85 | Bioorg Med Chem Lett, (2016) 26:17:4362 | ||||
ITK
Tyrosine-protein kinase ITK/TSK
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.58 | Bioorg Med Chem Lett, (2016) 26:17:4362 | ||||