CHEMBL573214
Ligand Summary
Name: (1S,2S,7S,8R,12S,20R,24R,32R)-9,33-bis(cyclopropylmethyl)-19,25-dioxa-9,22,33-triazaundecacyclo[24.9.1.1^{8,14}.0^{1,24}.0^{2,32}.0^{4,23}.0^{5,21}.0^{7,12}.0^{12,20}.0^{13,18}.0^{30,36}]heptatriaconta-4(23),5(21),13,15,17,26,28,30(36)-octaene-2,7,17,27-tetrol
PubChem: 5480230
Guide to Pharmacology: 1642
ChEMBL: CHEMBL573214
LyCHI: FZDU83R6H7HX
Target Activities
OPRK1
Kappa-type opioid receptor
26 Activities
Items per page:
1 – 10 of 26
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.89 | J. Med. Chem., (2000) 43:8:1573 | ||||
Ki | 7.89 | J. Med. Chem., (2000) 43:8:1573 | ||||
IC50 | 8.34 | Bioorg. Med. Chem., (2015) 23:14:3948 | ||||
IC50 | 8.6 | Bioorg. Med. Chem., (2015) 23:14:3948 | ||||
Ki | 9.05 | Bioorg. Med. Chem. Lett., (2010) 20:19:5847 | ||||
Ki | 9.07 | J. Med. Chem., (2011) 54:16:5868 | ||||
Ki | 9.4 | J. Med. Chem., (2005) 48:5:1676 | ||||
Ki | 9.43 | J. Med. Chem., (2003) 46:11:2104 | ||||
Ki | 9.44 | J. Med. Chem., (2000) 43:14:2698 | ||||
Ki | 9.47 | J. Med. Chem., (2010) 53:10:4212 | ||||
OPRD1
Delta-type opioid receptor
20 Activities
Items per page:
1 – 10 of 20
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.19 | J. Med. Chem., (2011) 54:16:5868 | ||||
Ki | 7.37 | J. Med. Chem., (1994) 37:10:1495 | ||||
Ki | 7.37 | J. Med. Chem., (1998) 41:26:5188 | ||||
Ki | 7.37 | J. Med. Chem., (1993) 36:1:179 | ||||
Ki | 7.41 | J. Med. Chem., (1991) 34:4:1292 | ||||
Ki | 7.62 | Bioorg. Med. Chem. Lett., (2009) 19:1:203 | ||||
IC50 | 7.66 | J. Med. Chem., (1992) 35:24:4589 | ||||
Ki | 7.71 | J. Med. Chem., (2003) 46:11:2104 | ||||
Ki | 7.72 | J. Med. Chem., (2000) 43:14:2698 | ||||
Ki | 8.18 | J. Med. Chem., (2011) 54:23:8000 | ||||
OPRM1
Mu-type opioid receptor
15 Activities
Items per page:
1 – 10 of 15
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.1 | J. Med. Chem., (2011) 54:16:5868 | ||||
Ki | 7.1 | J. Med. Chem., (2003) 46:11:2104 | ||||
Ki | 7.16 | J. Med. Chem., (2000) 43:8:1573 | ||||
Ki | 7.25 | J. Med. Chem., (2000) 43:14:2698 | ||||
Ki | 7.49 | J. Med. Chem., (2011) 54:23:8000 | ||||
Ki | 7.68 | J. Med. Chem., (2004) 47:21:5069 | ||||
Ki | 7.68 | J. Med. Chem., (2003) 46:14:3127 | ||||
Ki | 7.68 | Bioorg. Med. Chem. Lett., (2000) 10:20:2259 | ||||
Ki | 7.68 | J. Med. Chem., (2003) 46:8:1563 | ||||
Ki | 7.68 | J. Med. Chem., (2003) 46:2:314 | ||||