Pharos : Ligand Details

Target Activities

PIK3CA

Tclin

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

34 Activities

Items per page:

1 – 10 of 34

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.69999981		19584227

Kd	8.89	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.85	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.82	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	8.82	Nat. Biotechnol., (2008) 26:1:127	18183025

Kd	8.82	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.82	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.82	Nat. Biotechnol., (2011) 29:11:1046	22037378

Kd	8.82	Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	8.75	Bioorg Med Chem, (2017) 25:7:2156	28259529

MTOR

Tclin

Serine/threonine-protein kinase mTOR

14 Activities

Items per page:

1 – 10 of 14

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.51999998		19584227

IC50	8.28	Bioorg. Med. Chem., (2016) 24:5:957	26819001

IC50	8.28	Eur J Med Chem, (2019) 178:None:667	31228810

IC50	8.06	Eur. J. Med. Chem., (2016) 117:None:47	27089211

IC50	8.06	Eur J Med Chem, (2016) 122:None:684	27448924

Kd	7.92	Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	7.85	MedChemComm, (2016) 7:2:297

IC50	7.8	Bioorg. Med. Chem., (2015) 23:24:7585	26596710

IC50	7.8	Eur. J. Med. Chem., (2016) 108:None:644	26731167

IC50	7.72	Bioorg. Med. Chem., (2014) 22:24:6746	25468038

PIK3CB

Tchem

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

13 Activities

Items per page:

1 – 10 of 13

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.52000046		19584227

Kd	8.77	Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	8.52	Bioorg. Med. Chem., (2007) 15:17:5837	17601739

IC50	8.52	Bioorg. Med. Chem. Lett., (2007) 17:9:2438	17339109

IC50	8.52	Eur. J. Med. Chem., (2016) 108:None:644	26731167

IC50	8.42	Bioorg Med Chem, (2017) 25:7:2156	28259529

IC50	8.15	J Med Chem, (2020) 63:8:4256	32212730

IC50	8.05	Eur. J. Med. Chem., (2012) 57:None:85	23059543

IC50	7.96	Bioorg. Med. Chem., (2016) 24:5:957	26819001

IC50	7.92	Eur J Med Chem, (2016) 122:None:684	27448924

PIK3CD

Tclin

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

11 Activities

Items per page:

1 – 10 of 11

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.52000046		19584227

IC50	8.52	Eur. J. Med. Chem., (2016) 108:None:644	26731167

IC50	8.52	J Med Chem, (2020) 63:8:4256	32212730

IC50	8.24	MedChemComm, (2019) 10:3:413

IC50	8.08	Eur. J. Med. Chem., (2012) 57:None:85	23059543

IC50	8.03	Eur J Med Chem, (2016) 122:None:684	27448924

IC50	8	Bioorg. Med. Chem., (2015) 23:24:7585	26596710

IC50	8	MedChemComm, (2016) 7:2:297

IC50	7.89	Bioorg. Med. Chem., (2016) 24:5:957	26819001

IC50	7.82	Eur. J. Med. Chem., (2016) 108:None:644	26731167

PIK3CG

Tclin

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.82000017		19584227

IC50	7.82	Eur. J. Med. Chem., (2016) 108:None:644	26731167

Kd	7.8	Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	7.75	Eur J Med Chem, (2016) 122:None:684	27448924

IC50	7.58	Eur. J. Med. Chem., (2012) 57:None:85	23059543

PIK3C2B

Tchem

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8		17601739

IC50	8	Bioorg. Med. Chem., (2007) 15:17:5837	17601739

IC50	8	Bioorg. Med. Chem. Lett., (2007) 17:9:2438	17339109

Kd	8	Nat. Biotechnol., (2011) 29:11:1046	22037378

IC50	7.58	ACS Med. Chem. Lett., (2015) 6:1:3	25589915

PRKDC

Tchem

DNA-dependent protein kinase catalytic subunit

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.63999987		19584227

IC50	8.7	ACS Med. Chem. Lett., (2015) 6:1:3	25589915

IC50	7.85	J. Med. Chem., (2015) 58:1:41	25387153