Pharos : Ligand Details

Target Activities

Explore Associated and Predicted Targets

TNKS

Tchem

Tankyrase-1

4 Activities

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1 – 4 of 4

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	6.5	J. Med. Chem., (2013) 56:9:3507	23574272

IC50	6.49	J. Med. Chem., (2013) 56:9:3507	23574272

IC50	6.49	J. Med. Chem., (2013) 56:20:7880	24116873

IC50	6.48	J. Med. Chem., (2013) 56:20:7880	24116873

ADORA1

Tclin

Adenosine receptor A1

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
	4.5			8691424

	5.5			8691424

ADORA3

Tchem

Adenosine receptor A3

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
	4.3			8691424

	4.8			8691424

TNKS2

Tchem

Tankyrase-2

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	6.85	J. Med. Chem., (2013) 56:9:3507	23574272

IC50	6.83	J. Med. Chem., (2013) 56:9:3507	23574272

ADORA2A

Tclin

Adenosine receptor A2a

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
	5.5			8691424

DPP4

Tclin

Dipeptidyl peptidase 4

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.77		Eur J Med Chem, (2018) 151:None:145	29609120

CYP19A1

Tclin

Aromatase

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8.1		Bioorg. Med. Chem. Lett., (2010) 20:10:3050	20413308

CYP1B1

Tchem

Cytochrome P450 1B1

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.22		Eur J Med Chem, (2017) 135:None:296	28458135