CHEMBL459850
Ligand Summary
Name: N-(3-(7-amino-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide
PubChem: 10062694
ChEMBL: CHEMBL459850
LyCHI: CWD2YRCV9GS9
Target Activities
PDGFRB
Platelet-derived growth factor receptor beta
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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EC50 | 8.22 | Proc. Natl. Acad. Sci. U.S.A., (2007) 104:50:19936 | ||||
KIT
Mast/stem cell growth factor receptor Kit
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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EC50 | 8.4 | Proc. Natl. Acad. Sci. U.S.A., (2007) 104:50:19936 | ||||
PDGFRA
Platelet-derived growth factor receptor alpha
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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EC50 | 8.4 | Proc. Natl. Acad. Sci. U.S.A., (2007) 104:50:19936 | ||||
SRC
Proto-oncogene tyrosine-protein kinase Src
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 7.89 | Proc. Natl. Acad. Sci. U.S.A., (2007) 104:50:19936 | ||||
KDR
Vascular endothelial growth factor receptor 2
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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EC50 | 7.66 | Proc. Natl. Acad. Sci. U.S.A., (2007) 104:50:19936 | ||||
LCK
Tyrosine-protein kinase Lck
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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EC50 | 8.3 | Proc. Natl. Acad. Sci. U.S.A., (2007) 104:50:19936 | ||||
FGFR3
Fibroblast growth factor receptor 3
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 7.89 | Proc. Natl. Acad. Sci. U.S.A., (2007) 104:50:19936 | ||||
BMX
Cytoplasmic tyrosine-protein kinase BMX
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 8.85 | Proc. Natl. Acad. Sci. U.S.A., (2007) 104:50:19936 | ||||
TNK2
Activated CDC42 kinase 1
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 7.75 | J Med Chem, (2018) 61:18:8353 | ||||
EPHA3
Ephrin type-A receptor 3
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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EC50 | 8.7 | Proc. Natl. Acad. Sci. U.S.A., (2007) 104:50:19936 | ||||
MAP4K2
Mitogen-activated protein kinase kinase kinase kinase 2
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 7.55 | J Med Chem, (2018) 61:18:8353 | ||||
FES
Tyrosine-protein kinase Fes/Fps
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 9 | Proc. Natl. Acad. Sci. U.S.A., (2007) 104:50:19936 | ||||
KARS
Lysine--tRNA ligase
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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EC50 | 7.15 | Proc. Natl. Acad. Sci. U.S.A., (2007) 104:50:19936 | ||||
EPHB4
Ephrin type-B receptor 4
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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EC50 | 8.4 | Proc. Natl. Acad. Sci. U.S.A., (2007) 104:50:19936 | ||||