Pharos : Ligand Details

Target Activities

PIM1

Tchem

Serine/threonine-protein kinase pim-1

3 Activities

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1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.57	J. Med. Chem., (2005) 48:24:7604	16302800

IC50	7.57	J. Med. Chem., (2009) 52:1:74	19072652

Kd	8	J. Med. Chem., (2005) 48:24:7604	16302800

PRKCE

Tchem

Protein kinase C epsilon type

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.18	J. Med. Chem., (2009) 52:20:6193	19827831

IC50	8.22	J. Biol. Chem., (2007) 282:45:33052	17875639

PRKCA

Tchem

Protein kinase C alpha type

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8	Bioorg. Med. Chem. Lett., (1995) 5:5:497

IC50	8.64	J. Med. Chem., (2009) 52:20:6193	19827831

PRKCD

Tclin

Protein kinase C delta type

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8.06		J. Med. Chem., (2009) 52:20:6193	19827831

PRKCQ

Tchem

Protein kinase C theta type

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8.17		J. Med. Chem., (2009) 52:20:6193	19827831

PRKCH

Tchem

Protein kinase C eta type

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8		J. Med. Chem., (2009) 52:20:6193	19827831

PRKCB

Tchem

Protein kinase C beta type

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8.8		J. Med. Chem., (2009) 52:20:6193	19827831

KCNH2

Tclin

Potassium voltage-gated channel subfamily H member 2

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6		Eur. J. Med. Chem., (2011) 46:2:618	21185626