Pharos : Ligand Details

Target Activities

Explore Associated and Predicted Targets

HDAC1

Tclin

Histone deacetylase 1

238 Activities

Items per page:

1 – 10 of 238

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	8.89		20139990

Ki	8.89	Nat. Chem. Biol., (2010) 6:3:238	20139990

IC50	8.4	J. Med. Chem., (2013) 56:4:1772	23368884

IC50	8.4	Eur J Med Chem, (2019) 168:None:110	30802729

IC50	8.3	J. Med. Chem., (2013) 56:11:4816	23672185

IC50	8.26	Eur J Med Chem, (2018) 150:None:506	29549837

Ki	8.19	MedChemComm, (2016) 7:3:464

IC50	8.15	Bioorg. Med. Chem. Lett., (2016) 26:4:1265	26804233

IC50	8.15	J. Med. Chem., (2016) 59:4:1613	26681404

Ki	8.1	J. Med. Chem., (2013) 56:16:6512	23865683

HDAC6

Tclin

Histone deacetylase 6

207 Activities

Items per page:

1 – 10 of 207

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	8.8		20139990

Ki	9	Bioorg. Med. Chem. Lett., (2008) 18:9:2809	18430569

IC50	8.85	J. Med. Chem., (2016) 59:4:1613	26681404

Ki	8.8	Nat. Chem. Biol., (2010) 6:3:238	20139990

IC50	8.7	J. Med. Chem., (2013) 56:4:1772	23368884

IC50	8.7	J. Med. Chem., (2013) 56:11:4816	23672185

IC50	8.57	MedChemComm, (2014) 5:12:1829

IC50	8.55	ACS Med Chem Lett, (2017) 8:10:1031	29057046

IC50	8.3	J. Med. Chem., (2012) 55:8:3777	22439863

IC50	8.3	J Med Chem, (2020) 63:13:6959	32551649

HDAC2

Tclin

Histone deacetylase 2

135 Activities

Items per page:

1 – 10 of 135

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	8.8		20139990

Ki	8.8	Nat. Chem. Biol., (2010) 6:3:238	20139990

IC50	8.77	J. Med. Chem., (2012) 55:8:3777	22439863

Ki	8.38	MedChemComm, (2016) 7:3:464

Ki	8.15	J. Med. Chem., (2013) 56:16:6512	23865683

Ki	8.15	J. Med. Chem., (2014) 57:22:9644	25380299

Ki	8.1	MedChemComm, (2014) 5:12:1849

IC50	8	J. Med. Chem., (2013) 56:20:7997	24074025

IC50	7.99	Bioorg. Med. Chem. Lett., (2016) 26:4:1265	26804233

IC50	7.96	J. Med. Chem., (2013) 56:4:1772	23368884

HDAC3

Tclin

Histone deacetylase 3

102 Activities

Items per page:

1 – 10 of 102

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	8.3		20139990

IC50	8.85	J. Med. Chem., (2016) 59:4:1613	26681404

IC50	8.52	J. Med. Chem., (2013) 56:4:1772	23368884

IC50	8.4	J. Med. Chem., (2013) 56:11:4816	23672185

Ki	8.3	Nat. Chem. Biol., (2010) 6:3:238	20139990

IC50	8.18	ACS Med Chem Lett, (2020) 11:1:56	31938464

Ki	7.92	J. Med. Chem., (2014) 57:22:9644	25380299

IC50	7.77	Bioorg. Med. Chem. Lett., (2009) 19:11:3023	19419863

IC50	7.77	J. Med. Chem., (2008) 51:15:4370	18642892

IC50	7.77	J. Med. Chem., (2010) 53:3:1347	20055418

HDAC8

Tclin

Histone deacetylase 8

73 Activities

Items per page:

1 – 10 of 73

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.26	J. Med. Chem., (2015) 58:10:4325	25906087

IC50	8.06	ACS Med. Chem. Lett., (2015) 6:3:239	25815139

IC50	7.35	Bioorg. Med. Chem. Lett., (2010) 20:13:3906	20605448

IC50	6.96	Bioorg. Med. Chem., (2014) 22:14:3720	24864038

IC50	6.92	Eur. J. Med. Chem., (2016) 108:None:274	26689485

Ki	6.76	J. Med. Chem., (2011) 54:13:4694	21634430

IC50	6.76	J. Med. Chem., (2016) 59:4:1455	26443078

IC50	6.76	J Med Chem, (2019) 62:3:1577	30629434

IC50	6.75	J. Med. Chem., (2011) 54:7:2165	21417297

IC50	6.71	J Med Chem, (2020) 63:7:3678	32153186

HDAC10

Tclin

Histone deacetylase 10

39 Activities

Items per page:

1 – 10 of 39

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	7.3		20451378

Ki	7.4	J. Med. Chem., (2014) 57:22:9644	25380299

Ki	7.4	MedChemComm, (2014) 5:12:1849

Ki	7.3	Bioorg. Med. Chem. Lett., (2010) 20:11:3314	20451378

IC50	7.24	ACS Med. Chem. Lett., (2011) 2:9:703	21984958

Ki	7.22	J. Med. Chem., (2011) 54:13:4694	21634430

IC50	7.19	Eur. J. Med. Chem., (2016) 108:None:274	26689485

IC50	7.17	J Med Chem, (2019) 62:7:3171	30418766

IC50	7.16	J. Nat. Prod., (2014) 77:1:49	24328302

IC50	7.14	Bioorg. Med. Chem. Lett., (2009) 19:11:3023	19419863

HDAC11

Tclin

Histone deacetylase 11

25 Activities

Items per page:

1 – 10 of 25

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	7.44		20451378

Ki	7.89	J. Med. Chem., (2013) 56:16:6512	23865683

Ki	7.89	J. Med. Chem., (2014) 57:22:9644	25380299

Ki	7.51	J. Med. Chem., (2011) 54:13:4694	21634430

IC50	7.46	J. Med. Chem., (2015) 58:10:4325	25906087

Ki	7.44	Bioorg. Med. Chem. Lett., (2010) 20:11:3314	20451378

IC50	7.29	J Med Chem, (2019) 62:7:3171	30418766

Ki	7.22	MedChemComm, (2014) 5:12:1849

IC50	7.05	J. Nat. Prod., (2014) 77:1:49	24328302

IC50	7	J. Med. Chem., (2011) 54:7:2165	21417297

HDAC4

Tclin

Histone deacetylase 4

19 Activities

Items per page:

1 – 10 of 19

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	7.8	Bioorg. Med. Chem. Lett., (2010) 20:11:3314	20451378

Ki	7.7	J. Med. Chem., (2011) 54:13:4694	21634430

IC50	7.4	J. Med. Chem., (2013) 56:24:9934	24261862

IC50	7.04	Eur J Med Chem, (2018) 146:None:79	29396364

IC50	7	Eur. J. Med. Chem., (2009) 44:3:1067	18672316

IC50	6.95	J Med Chem, (2019) 62:7:3171	30418766

IC50	6.82	Bioorg. Med. Chem., (2014) 22:14:3720	24864038

IC50	6.68	J. Med. Chem., (2011) 54:7:2165	21417297

IC50	6.52	Nat. Chem. Biol., (2010) 6:1:25	19966789

IC50	6.47	Eur J Med Chem, (2018) 158:None:620	30245394

HDAC5

Tclin

Histone deacetylase 5

12 Activities

Items per page:

1 – 10 of 12

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	5.44		20139990

Ki	7.48	Bioorg. Med. Chem. Lett., (2010) 20:11:3314	20451378

Ki	7.44	J. Med. Chem., (2011) 54:13:4694	21634430

IC50	6.97	Eur. J. Med. Chem., (2009) 44:3:1067	18672316

IC50	6.82	J. Med. Chem., (2011) 54:7:2165	21417297

IC50	6.42	J. Med. Chem., (2010) 53:23:8387	21073160

IC50	6.42	Eur. J. Med. Chem., (2014) 79:None:251	24742384

IC50	6.42	Eur. J. Med. Chem., (2014) 76:None:53	24565573

IC50	6.42	J. Med. Chem., (2014) 57:6:2258	24588105

IC50	6.42	Eur. J. Med. Chem., (2016) 112:None:99	26890116

HDAC9

Tclin

Histone deacetylase 9

11 Activities

Items per page:

1 – 10 of 11

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	7.19		20451378

IC50	7.7	J. Med. Chem., (2011) 54:7:2165	21417297

IC50	7.42	Bioorg. Med. Chem., (2014) 22:14:3720	24864038

Ki	7.31	J. Med. Chem., (2011) 54:13:4694	21634430

Ki	7.19	Bioorg. Med. Chem. Lett., (2010) 20:11:3314	20451378

IC50	6.97	Eur. J. Med. Chem., (2009) 44:3:1067	18672316

IC50	6.7	Nat. Chem. Biol., (2010) 6:1:25	19966789

IC50	6.5	J. Med. Chem., (2010) 53:23:8387	21073160

IC50	6.5	Eur. J. Med. Chem., (2014) 79:None:251	24742384

IC50	6.5	J. Med. Chem., (2014) 57:6:2258	24588105

HDAC7

Tclin

Histone deacetylase 7

10 Activities

Items per page:

1 – 10 of 10

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.67	J Med Chem, (2019) 62:7:3171	30418766

IC50	7.47	Eur. J. Med. Chem., (2016) 112:None:99	26890116

IC50	7.46	Eur. J. Med. Chem., (2014) 79:None:251	24742384

IC50	6.99	Eur. J. Med. Chem., (2009) 44:3:1067	18672316

Ki	6.89	J. Med. Chem., (2011) 54:13:4694	21634430

IC50	6.46	J. Med. Chem., (2010) 53:23:8387	21073160

IC50	6.46	Eur. J. Med. Chem., (2014) 76:None:53	24565573

IC50	6.46	J. Med. Chem., (2014) 57:6:2258	24588105

IC50	6.3	Nat. Chem. Biol., (2010) 6:1:25	19966789

IC50	6.1	Eur J Med Chem, (2018) 158:None:620	30245394

BRD4

Tchem

Bromodomain-containing protein 4

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8	Bioorg Med Chem Lett, (2017) 27:17:4051	28765013

IC50	6.13	Bioorg Med Chem, (2017) 25:14:3677	28549889

IC50	8	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL98

NCOR2

Tchem

Nuclear receptor corepressor 2

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.7		https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL98

NCOR1

Tchem

Nuclear receptor corepressor 1

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.92		https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL98