vorinostat
Ligand Summary
A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.
UNII: 58IFB293JI
PubChem: 5311
Guide to Pharmacology: 6852
ChEMBL: CHEMBL98
DrugCentral: 4124
LyCHI: 3A6WF2F4D5BG
Target Activities
HDAC1
Histone deacetylase 1
238 Activities
Items per page:
1 – 10 of 238
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 8.89 | |||||
Ki | 8.89 | Nat. Chem. Biol., (2010) 6:3:238 | ||||
IC50 | 8.4 | J. Med. Chem., (2013) 56:4:1772 | ||||
IC50 | 8.4 | Eur J Med Chem, (2019) 168:None:110 | ||||
IC50 | 8.3 | J. Med. Chem., (2013) 56:11:4816 | ||||
IC50 | 8.26 | Eur J Med Chem, (2018) 150:None:506 | ||||
Ki | 8.19 | MedChemComm, (2016) 7:3:464 | ||||
IC50 | 8.15 | Bioorg. Med. Chem. Lett., (2016) 26:4:1265 | ||||
IC50 | 8.15 | J. Med. Chem., (2016) 59:4:1613 | ||||
Ki | 8.1 | J. Med. Chem., (2013) 56:16:6512 | ||||
HDAC6
Histone deacetylase 6
207 Activities
Items per page:
1 – 10 of 207
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 8.8 | |||||
Ki | 9 | Bioorg. Med. Chem. Lett., (2008) 18:9:2809 | ||||
IC50 | 8.85 | J. Med. Chem., (2016) 59:4:1613 | ||||
Ki | 8.8 | Nat. Chem. Biol., (2010) 6:3:238 | ||||
IC50 | 8.7 | J. Med. Chem., (2013) 56:4:1772 | ||||
IC50 | 8.7 | J. Med. Chem., (2013) 56:11:4816 | ||||
IC50 | 8.57 | MedChemComm, (2014) 5:12:1829 | ||||
IC50 | 8.55 | ACS Med Chem Lett, (2017) 8:10:1031 | ||||
IC50 | 8.3 | J. Med. Chem., (2012) 55:8:3777 | ||||
IC50 | 8.3 | J Med Chem, (2020) 63:13:6959 | ||||
HDAC2
Histone deacetylase 2
135 Activities
Items per page:
1 – 10 of 135
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 8.8 | |||||
Ki | 8.8 | Nat. Chem. Biol., (2010) 6:3:238 | ||||
IC50 | 8.77 | J. Med. Chem., (2012) 55:8:3777 | ||||
Ki | 8.38 | MedChemComm, (2016) 7:3:464 | ||||
Ki | 8.15 | J. Med. Chem., (2013) 56:16:6512 | ||||
Ki | 8.15 | J. Med. Chem., (2014) 57:22:9644 | ||||
Ki | 8.1 | MedChemComm, (2014) 5:12:1849 | ||||
IC50 | 8 | J. Med. Chem., (2013) 56:20:7997 | ||||
IC50 | 7.99 | Bioorg. Med. Chem. Lett., (2016) 26:4:1265 | ||||
IC50 | 7.96 | J. Med. Chem., (2013) 56:4:1772 | ||||
HDAC3
Histone deacetylase 3
102 Activities
Items per page:
1 – 10 of 102
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 8.3 | |||||
IC50 | 8.85 | J. Med. Chem., (2016) 59:4:1613 | ||||
IC50 | 8.52 | J. Med. Chem., (2013) 56:4:1772 | ||||
IC50 | 8.4 | J. Med. Chem., (2013) 56:11:4816 | ||||
Ki | 8.3 | Nat. Chem. Biol., (2010) 6:3:238 | ||||
IC50 | 8.18 | ACS Med Chem Lett, (2020) 11:1:56 | ||||
Ki | 7.92 | J. Med. Chem., (2014) 57:22:9644 | ||||
IC50 | 7.77 | Bioorg. Med. Chem. Lett., (2009) 19:11:3023 | ||||
IC50 | 7.77 | J. Med. Chem., (2008) 51:15:4370 | ||||
IC50 | 7.77 | J. Med. Chem., (2010) 53:3:1347 | ||||
HDAC8
Histone deacetylase 8
73 Activities
Items per page:
1 – 10 of 73
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 8.26 | J. Med. Chem., (2015) 58:10:4325 | ||||
IC50 | 8.06 | ACS Med. Chem. Lett., (2015) 6:3:239 | ||||
IC50 | 7.35 | Bioorg. Med. Chem. Lett., (2010) 20:13:3906 | ||||
IC50 | 6.96 | Bioorg. Med. Chem., (2014) 22:14:3720 | ||||
IC50 | 6.92 | Eur. J. Med. Chem., (2016) 108:None:274 | ||||
Ki | 6.76 | J. Med. Chem., (2011) 54:13:4694 | ||||
IC50 | 6.76 | J. Med. Chem., (2016) 59:4:1455 | ||||
IC50 | 6.76 | J Med Chem, (2019) 62:3:1577 | ||||
IC50 | 6.75 | J. Med. Chem., (2011) 54:7:2165 | ||||
IC50 | 6.71 | J Med Chem, (2020) 63:7:3678 | ||||
HDAC10
Histone deacetylase 10
39 Activities
Items per page:
1 – 10 of 39
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 7.3 | |||||
Ki | 7.4 | J. Med. Chem., (2014) 57:22:9644 | ||||
Ki | 7.4 | MedChemComm, (2014) 5:12:1849 | ||||
Ki | 7.3 | Bioorg. Med. Chem. Lett., (2010) 20:11:3314 | ||||
IC50 | 7.24 | ACS Med. Chem. Lett., (2011) 2:9:703 | ||||
Ki | 7.22 | J. Med. Chem., (2011) 54:13:4694 | ||||
IC50 | 7.19 | Eur. J. Med. Chem., (2016) 108:None:274 | ||||
IC50 | 7.17 | J Med Chem, (2019) 62:7:3171 | ||||
IC50 | 7.16 | J. Nat. Prod., (2014) 77:1:49 | ||||
IC50 | 7.14 | Bioorg. Med. Chem. Lett., (2009) 19:11:3023 | ||||
HDAC11
Histone deacetylase 11
25 Activities
Items per page:
1 – 10 of 25
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 7.44 | |||||
Ki | 7.89 | J. Med. Chem., (2013) 56:16:6512 | ||||
Ki | 7.89 | J. Med. Chem., (2014) 57:22:9644 | ||||
Ki | 7.51 | J. Med. Chem., (2011) 54:13:4694 | ||||
IC50 | 7.46 | J. Med. Chem., (2015) 58:10:4325 | ||||
Ki | 7.44 | Bioorg. Med. Chem. Lett., (2010) 20:11:3314 | ||||
IC50 | 7.29 | J Med Chem, (2019) 62:7:3171 | ||||
Ki | 7.22 | MedChemComm, (2014) 5:12:1849 | ||||
IC50 | 7.05 | J. Nat. Prod., (2014) 77:1:49 | ||||
IC50 | 7 | J. Med. Chem., (2011) 54:7:2165 | ||||
HDAC4
Histone deacetylase 4
19 Activities
Items per page:
1 – 10 of 19
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 7.8 | Bioorg. Med. Chem. Lett., (2010) 20:11:3314 | ||||
Ki | 7.7 | J. Med. Chem., (2011) 54:13:4694 | ||||
IC50 | 7.4 | J. Med. Chem., (2013) 56:24:9934 | ||||
IC50 | 7.04 | Eur J Med Chem, (2018) 146:None:79 | ||||
IC50 | 7 | Eur. J. Med. Chem., (2009) 44:3:1067 | ||||
IC50 | 6.95 | J Med Chem, (2019) 62:7:3171 | ||||
IC50 | 6.82 | Bioorg. Med. Chem., (2014) 22:14:3720 | ||||
IC50 | 6.68 | J. Med. Chem., (2011) 54:7:2165 | ||||
IC50 | 6.52 | Nat. Chem. Biol., (2010) 6:1:25 | ||||
IC50 | 6.47 | Eur J Med Chem, (2018) 158:None:620 | ||||
HDAC5
Histone deacetylase 5
12 Activities
Items per page:
1 – 10 of 12
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 5.44 | |||||
Ki | 7.48 | Bioorg. Med. Chem. Lett., (2010) 20:11:3314 | ||||
Ki | 7.44 | J. Med. Chem., (2011) 54:13:4694 | ||||
IC50 | 6.97 | Eur. J. Med. Chem., (2009) 44:3:1067 | ||||
IC50 | 6.82 | J. Med. Chem., (2011) 54:7:2165 | ||||
IC50 | 6.42 | J. Med. Chem., (2010) 53:23:8387 | ||||
IC50 | 6.42 | Eur. J. Med. Chem., (2014) 79:None:251 | ||||
IC50 | 6.42 | Eur. J. Med. Chem., (2014) 76:None:53 | ||||
IC50 | 6.42 | J. Med. Chem., (2014) 57:6:2258 | ||||
IC50 | 6.42 | Eur. J. Med. Chem., (2016) 112:None:99 | ||||
HDAC9
Histone deacetylase 9
11 Activities
Items per page:
1 – 10 of 11
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 7.19 | |||||
IC50 | 7.7 | J. Med. Chem., (2011) 54:7:2165 | ||||
IC50 | 7.42 | Bioorg. Med. Chem., (2014) 22:14:3720 | ||||
Ki | 7.31 | J. Med. Chem., (2011) 54:13:4694 | ||||
Ki | 7.19 | Bioorg. Med. Chem. Lett., (2010) 20:11:3314 | ||||
IC50 | 6.97 | Eur. J. Med. Chem., (2009) 44:3:1067 | ||||
IC50 | 6.7 | Nat. Chem. Biol., (2010) 6:1:25 | ||||
IC50 | 6.5 | J. Med. Chem., (2010) 53:23:8387 | ||||
IC50 | 6.5 | Eur. J. Med. Chem., (2014) 79:None:251 | ||||
IC50 | 6.5 | J. Med. Chem., (2014) 57:6:2258 | ||||
HDAC7
Histone deacetylase 7
10 Activities
Items per page:
1 – 10 of 10
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 7.67 | J Med Chem, (2019) 62:7:3171 | ||||
IC50 | 7.47 | Eur. J. Med. Chem., (2016) 112:None:99 | ||||
IC50 | 7.46 | Eur. J. Med. Chem., (2014) 79:None:251 | ||||
IC50 | 6.99 | Eur. J. Med. Chem., (2009) 44:3:1067 | ||||
Ki | 6.89 | J. Med. Chem., (2011) 54:13:4694 | ||||
IC50 | 6.46 | J. Med. Chem., (2010) 53:23:8387 | ||||
IC50 | 6.46 | Eur. J. Med. Chem., (2014) 76:None:53 | ||||
IC50 | 6.46 | J. Med. Chem., (2014) 57:6:2258 | ||||
IC50 | 6.3 | Nat. Chem. Biol., (2010) 6:1:25 | ||||
IC50 | 6.1 | Eur J Med Chem, (2018) 158:None:620 | ||||
BRD4
Bromodomain-containing protein 4
3 Activities
Items per page:
1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 8 | Bioorg Med Chem Lett, (2017) 27:17:4051 | ||||
IC50 | 6.13 | Bioorg Med Chem, (2017) 25:14:3677 | ||||
IC50 | 8 | |||||
NCOR2
Nuclear receptor corepressor 2
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 8.7 | |||||
NCOR1
Nuclear receptor corepressor 1
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 7.92 | |||||