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teriflunomide

Ligand Summary
Ligand Structure
Rendered image for the query structure
Description
Teriflunomide, an immunomodulatory agent with anti-inflammatory properties, inhibits dihydroorotate dehydrogenase, a mitochondrial enzyme involved in de novo pyrimidine synthesis. The exact mechanism by which teriflunomide exerts its therapeutic effect in multiple sclerosis is unknown but may involve a reduction in the number of activated lymphocytes in CNS.
Synonyms & Links
Guide to Pharmacology: 6844
DrugCentral: 4634
LyCHI:  93Z6KA6P5Q55


Target Activities