timolol
Ligand Summary
A beta-adrenergic antagonist that is similar in action to PROPRANOLOL; the levo-isomer is more active. Timolol has been proposed as an anti-hypertensive, anti-arrhythmic, anti-angina, and anti-glaucoma agent. It is also used in the treatment of MIGRAINE DISORDERS and tremor.
UNII: 5JKY92S7BR
PubChem: 33624
Guide to Pharmacology: 565
ChEMBL: CHEMBL499
DrugCentral: 4061
LyCHI: 952J8AXNZB3W
Target Activities
ADRB2
Beta-2 adrenergic receptor
5 Activities
Items per page:
1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
- | 9.7 | |||||
Ki | 9.7 | None, None:None:None | ||||
Ki | 9.68 | J Med Chem, (2018) 61:12:5380 | ||||
IC50 | 9.54 | None, None:None:None | ||||
Ki | 9.7 | ANTAGONIST | ||||
ADRB1
Beta-1 adrenergic receptor
4 Activities
Items per page:
1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 8.82 | None, None:None:None | ||||
IC50 | 8.59 | None, None:None:None | ||||
Ki | 8.27 | J Med Chem, (2018) 61:12:5380 | ||||
Ki | 9 | ANTAGONIST | ||||