Pharos : Ligand Details

Target Activities

Explore Associated and Predicted Targets

HDAC1

Tclin

Histone deacetylase 1

24 Activities

Items per page:

1 – 10 of 24

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
EC50	8.52		17868033

Ki	9.27	Bioorg Med Chem Lett, (2018) 28:17:2985	30122227

IC50	9.22	Bioorg Med Chem Lett, (2019) 29:16:2136	31272794

Ki	9	Nat. Chem. Biol., (2010) 6:3:238	20139990

Ki	9	Bioorg. Med. Chem., (2015) 23:16:5151	25637120

IC50	9	J. Med. Chem., (2016) 59:4:1455	26443078

IC50	9	Bioorg. Med. Chem., (2016) 24:18:4008	27377864

IC50	8.9	J. Med. Chem., (2016) 59:11:5488	27186676

IC50	8.85	J Med Chem, (2019) 62:7:3171	30418766

IC50	8.75	J Med Chem, (2020) 63:10:5501	32321249

HDAC6

Tclin

Histone deacetylase 6

18 Activities

Items per page:

1 – 10 of 18

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
EC50	7.21		17868033

Ki	9.15	J. Med. Chem., (2011) 54:13:4694	21634430

Ki	8.82	Nat. Chem. Biol., (2010) 6:3:238	20139990

Ki	8.82	Bioorg. Med. Chem., (2015) 23:16:5151	25637120

IC50	8.7	Bioorg. Med. Chem., (2016) 24:18:4008	27377864

IC50	8.4	J. Med. Chem., (2016) 59:4:1455	26443078

IC50	8.38	J. Med. Chem., (2016) 59:11:5488	27186676

IC50	8.21	J Med Chem, (2020) 63:2:804	31855601

IC50	7.98	J Med Chem, (2016) 59:19:8967	27606546

IC50	7.98	J Med Chem, (2020) 63:10:5501	32321249

HDAC2

Tclin

Histone deacetylase 2

17 Activities

Items per page:

1 – 10 of 17

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
EC50	8.52		17868033

Ki	9.19	Nat. Chem. Biol., (2010) 6:3:238	20139990

Ki	9.15	Bioorg. Med. Chem., (2015) 23:16:5151	25637120

Ki	8.72	J. Med. Chem., (2011) 54:13:4694	21634430

IC50	8.7	Bioorg. Med. Chem., (2016) 24:18:4008	27377864

IC50	8.52	J. Med. Chem., (2016) 59:4:1455	26443078

IC50	8.48	J. Med. Chem., (2016) 59:11:5488	27186676

IC50	8.17	J Med Chem, (2019) 62:7:3171	30418766

IC50	7.89	Drug Metab. Dispos., (2012) 40:5:1041	22344701

Ki	7.89	Bioorg Med Chem, (2019) 27:19:115036	31431326

HDAC3

Tclin

Histone deacetylase 3

14 Activities

Items per page:

1 – 10 of 14

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
EC50	8.4		17868033

Ki	8.96	Nat. Chem. Biol., (2010) 6:3:238	20139990

Ki	8.96	Bioorg. Med. Chem., (2015) 23:16:5151	25637120

IC50	8.82	J Med Chem, (2019) 62:7:3171	30418766

IC50	8.7	J. Med. Chem., (2016) 59:4:1455	26443078

IC50	8.7	Bioorg. Med. Chem., (2016) 24:18:4008	27377864

IC50	8.68	Drug Metab. Dispos., (2012) 40:5:1041	22344701

IC50	8.68	J Med Chem, (2016) 59:19:8967	27606546

IC50	8.68	J Med Chem, (2020) 63:10:5501	32321249

Ki	8.64	J. Med. Chem., (2011) 54:13:4694	21634430

HDAC8

Tclin

Histone deacetylase 8

14 Activities

Items per page:

1 – 10 of 14

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
EC50	6.61		17868033

IC50	8.31	J. Med. Chem., (2016) 59:11:5488	27186676

IC50	8.3	J. Med. Chem., (2016) 59:4:1455	26443078

IC50	7.7	J Med Chem, (2020) 63:2:804	31855601

Ki	7.66	J. Med. Chem., (2011) 54:13:4694	21634430

Ki	6.98	Nat. Chem. Biol., (2010) 6:3:238	20139990

Ki	6.98	Bioorg. Med. Chem., (2015) 23:16:5151	25637120

Ki	6.77	Bioorg Med Chem Lett, (2018) 28:17:2985	30122227

IC50	6.64	Bioorg. Med. Chem., (2016) 24:18:4008	27377864

IC50	6.56	J Med Chem, (2020) 63:10:5501	32321249

HDAC4

Tclin

Histone deacetylase 4

13 Activities

Items per page:

1 – 10 of 13

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
EC50	7.92		17868033

Ki	9.22	J. Med. Chem., (2011) 54:13:4694	21634430

IC50	7.57	J Med Chem, (2019) 62:7:3171	30418766

Ki	6.77	Bioorg Med Chem Lett, (2018) 28:17:2985	30122227

IC50	6.7	Drug Metab. Dispos., (2012) 40:5:1041	22344701

IC50	6.69	J Med Chem, (2020) 63:10:5501	32321249

IC50	6.47	J. Med. Chem., (2016) 59:4:1455	26443078

IC50	6.47	J. Med. Chem., (2016) 59:11:5488	27186676

IC50	6.43	Bioorg. Med. Chem., (2016) 24:18:4008	27377864

Ki	6.26	Nat. Chem. Biol., (2010) 6:3:238	20139990

HDAC5

Tclin

Histone deacetylase 5

10 Activities

Items per page:

1 – 10 of 10

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	9.15		J. Med. Chem., (2011) 54:13:4694	21634430

IC50	8.11		J Med Chem, (2020) 63:10:5501	32321249

Ki	7.24		Bioorg Med Chem Lett, (2018) 28:17:2985	30122227

Ki	7.1		Nat. Chem. Biol., (2010) 6:3:238	20139990

Ki	7.1		Bioorg. Med. Chem., (2015) 23:16:5151	25637120

IC50	7.04		Bioorg. Med. Chem., (2016) 24:18:4008	27377864

IC50	6.72		J. Med. Chem., (2016) 59:4:1455	26443078

IC50	6.72		J. Med. Chem., (2016) 59:11:5488	27186676

IC50	6.71		J Med Chem, (2019) 62:7:3171	30418766

Ki	9.15	INHIBITOR	http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/205353s000lbl.pdf

HDAC9

Tclin

Histone deacetylase 9

8 Activities

Items per page:

1 – 8 of 8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
EC50	8.52			17868033

Ki	8.92		J. Med. Chem., (2011) 54:13:4694	21634430

IC50	8.24		J Med Chem, (2020) 63:10:5501	32321249

Ki	6.08		Bioorg Med Chem Lett, (2018) 28:17:2985	30122227

IC50	6.05		J. Med. Chem., (2016) 59:4:1455	26443078

IC50	6.05		J. Med. Chem., (2016) 59:11:5488	27186676

IC50	6.04		J Med Chem, (2019) 62:7:3171	30418766

Ki	8.92	INHIBITOR	http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/205353s000lbl.pdf

HDAC10

Tclin

Histone deacetylase 10

7 Activities

Items per page:

1 – 7 of 7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8.68		J Med Chem, (2019) 62:7:3171	30418766

IC50	8.4		J. Med. Chem., (2016) 59:4:1455	26443078

IC50	8.35		J. Med. Chem., (2016) 59:11:5488	27186676

Ki	8.29		Bioorg Med Chem Lett, (2018) 28:17:2985	30122227

IC50	7.99		J Med Chem, (2020) 63:2:804	31855601

Ki	7.51		J. Med. Chem., (2011) 54:13:4694	21634430

Ki	7.51	INHIBITOR	http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/205353s000lbl.pdf

HDAC7

Tclin

Histone deacetylase 7

6 Activities

Items per page:

1 – 6 of 6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
EC50	7.85			17868033

Ki	8.64		J. Med. Chem., (2011) 54:13:4694	21634430

IC50	8.09		J Med Chem, (2019) 62:7:3171	30418766

IC50	6.28		J Med Chem, (2020) 63:10:5501	32321249

Ki	6.2		Bioorg Med Chem Lett, (2018) 28:17:2985	30122227

Ki	8.64	INHIBITOR	http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/205353s000lbl.pdf

HDAC11

Tclin

Histone deacetylase 11

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8.8		J Med Chem, (2019) 62:7:3171	30418766

Ki	8.46		J. Med. Chem., (2011) 54:13:4694	21634430

IC50	6.92		J Med Chem, (2020) 63:2:804	31855601

Ki	8.46	INHIBITOR	http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/205353s000lbl.pdf

BRD4

Tchem

Bromodomain-containing protein 4

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	8.3	Bioorg Med Chem Lett, (2017) 27:17:4051	28765013

IC50	8.3	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL483254