panobinostat
An indole and hydroxamic acid derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used as an antineoplastic agent in combination with BORTEZOMIB and DEXAMETHASONE for the treatment of MULTIPLE MYELOMA.
Ligand Summary
UNII: 9647FM7Y3Z
PubChem: 6918837
Guide to Pharmacology: 7489
ChEMBL: CHEMBL483254
DrugCentral: 4682
LyCHI: DV83J283Y51H
Target Activities
HDAC1
Histone deacetylase 1
24 Activities
Items per page:
1 – 10 of 24
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
EC50 | 8.52 | |||||
Ki | 9.27 | Bioorg Med Chem Lett, (2018) 28:17:2985 | ||||
IC50 | 9.22 | Bioorg Med Chem Lett, (2019) 29:16:2136 | ||||
Ki | 9 | Nat. Chem. Biol., (2010) 6:3:238 | ||||
Ki | 9 | Bioorg. Med. Chem., (2015) 23:16:5151 | ||||
IC50 | 9 | J. Med. Chem., (2016) 59:4:1455 | ||||
IC50 | 9 | Bioorg. Med. Chem., (2016) 24:18:4008 | ||||
IC50 | 8.9 | J. Med. Chem., (2016) 59:11:5488 | ||||
IC50 | 8.85 | J Med Chem, (2019) 62:7:3171 | ||||
IC50 | 8.75 | J Med Chem, (2020) 63:10:5501 | ||||
HDAC6
Histone deacetylase 6
18 Activities
Items per page:
1 – 10 of 18
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
EC50 | 7.21 | |||||
Ki | 9.15 | J. Med. Chem., (2011) 54:13:4694 | ||||
Ki | 8.82 | Nat. Chem. Biol., (2010) 6:3:238 | ||||
Ki | 8.82 | Bioorg. Med. Chem., (2015) 23:16:5151 | ||||
IC50 | 8.7 | Bioorg. Med. Chem., (2016) 24:18:4008 | ||||
IC50 | 8.4 | J. Med. Chem., (2016) 59:4:1455 | ||||
IC50 | 8.38 | J. Med. Chem., (2016) 59:11:5488 | ||||
IC50 | 8.21 | J Med Chem, (2020) 63:2:804 | ||||
IC50 | 7.98 | J Med Chem, (2016) 59:19:8967 | ||||
IC50 | 7.98 | J Med Chem, (2020) 63:10:5501 | ||||
HDAC2
Histone deacetylase 2
17 Activities
Items per page:
1 – 10 of 17
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
EC50 | 8.52 | |||||
Ki | 9.19 | Nat. Chem. Biol., (2010) 6:3:238 | ||||
Ki | 9.15 | Bioorg. Med. Chem., (2015) 23:16:5151 | ||||
Ki | 8.72 | J. Med. Chem., (2011) 54:13:4694 | ||||
IC50 | 8.7 | Bioorg. Med. Chem., (2016) 24:18:4008 | ||||
IC50 | 8.52 | J. Med. Chem., (2016) 59:4:1455 | ||||
IC50 | 8.48 | J. Med. Chem., (2016) 59:11:5488 | ||||
IC50 | 8.17 | J Med Chem, (2019) 62:7:3171 | ||||
IC50 | 7.89 | Drug Metab. Dispos., (2012) 40:5:1041 | ||||
Ki | 7.89 | Bioorg Med Chem, (2019) 27:19:115036 | ||||
HDAC3
Histone deacetylase 3
14 Activities
Items per page:
1 – 10 of 14
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
EC50 | 8.4 | |||||
Ki | 8.96 | Nat. Chem. Biol., (2010) 6:3:238 | ||||
Ki | 8.96 | Bioorg. Med. Chem., (2015) 23:16:5151 | ||||
IC50 | 8.82 | J Med Chem, (2019) 62:7:3171 | ||||
IC50 | 8.7 | J. Med. Chem., (2016) 59:4:1455 | ||||
IC50 | 8.7 | Bioorg. Med. Chem., (2016) 24:18:4008 | ||||
IC50 | 8.68 | Drug Metab. Dispos., (2012) 40:5:1041 | ||||
IC50 | 8.68 | J Med Chem, (2016) 59:19:8967 | ||||
IC50 | 8.68 | J Med Chem, (2020) 63:10:5501 | ||||
Ki | 8.64 | J. Med. Chem., (2011) 54:13:4694 | ||||
HDAC8
Histone deacetylase 8
14 Activities
Items per page:
1 – 10 of 14
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
EC50 | 6.61 | |||||
IC50 | 8.31 | J. Med. Chem., (2016) 59:11:5488 | ||||
IC50 | 8.3 | J. Med. Chem., (2016) 59:4:1455 | ||||
IC50 | 7.7 | J Med Chem, (2020) 63:2:804 | ||||
Ki | 7.66 | J. Med. Chem., (2011) 54:13:4694 | ||||
Ki | 6.98 | Nat. Chem. Biol., (2010) 6:3:238 | ||||
Ki | 6.98 | Bioorg. Med. Chem., (2015) 23:16:5151 | ||||
Ki | 6.77 | Bioorg Med Chem Lett, (2018) 28:17:2985 | ||||
IC50 | 6.64 | Bioorg. Med. Chem., (2016) 24:18:4008 | ||||
IC50 | 6.56 | J Med Chem, (2020) 63:10:5501 | ||||
HDAC4
Histone deacetylase 4
13 Activities
Items per page:
1 – 10 of 13
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
EC50 | 7.92 | |||||
Ki | 9.22 | J. Med. Chem., (2011) 54:13:4694 | ||||
IC50 | 7.57 | J Med Chem, (2019) 62:7:3171 | ||||
Ki | 6.77 | Bioorg Med Chem Lett, (2018) 28:17:2985 | ||||
IC50 | 6.7 | Drug Metab. Dispos., (2012) 40:5:1041 | ||||
IC50 | 6.69 | J Med Chem, (2020) 63:10:5501 | ||||
IC50 | 6.47 | J. Med. Chem., (2016) 59:4:1455 | ||||
IC50 | 6.47 | J. Med. Chem., (2016) 59:11:5488 | ||||
IC50 | 6.43 | Bioorg. Med. Chem., (2016) 24:18:4008 | ||||
Ki | 6.26 | Nat. Chem. Biol., (2010) 6:3:238 | ||||
HDAC5
Histone deacetylase 5
10 Activities
Items per page:
1 – 10 of 10
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 9.15 | J. Med. Chem., (2011) 54:13:4694 | ||||
IC50 | 8.11 | J Med Chem, (2020) 63:10:5501 | ||||
Ki | 7.24 | Bioorg Med Chem Lett, (2018) 28:17:2985 | ||||
Ki | 7.1 | Nat. Chem. Biol., (2010) 6:3:238 | ||||
Ki | 7.1 | Bioorg. Med. Chem., (2015) 23:16:5151 | ||||
IC50 | 7.04 | Bioorg. Med. Chem., (2016) 24:18:4008 | ||||
IC50 | 6.72 | J. Med. Chem., (2016) 59:4:1455 | ||||
IC50 | 6.72 | J. Med. Chem., (2016) 59:11:5488 | ||||
IC50 | 6.71 | J Med Chem, (2019) 62:7:3171 | ||||
Ki | 9.15 | INHIBITOR | ||||
HDAC9
Histone deacetylase 9
8 Activities
Items per page:
1 – 8 of 8
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
EC50 | 8.52 | |||||
Ki | 8.92 | J. Med. Chem., (2011) 54:13:4694 | ||||
IC50 | 8.24 | J Med Chem, (2020) 63:10:5501 | ||||
Ki | 6.08 | Bioorg Med Chem Lett, (2018) 28:17:2985 | ||||
IC50 | 6.05 | J. Med. Chem., (2016) 59:4:1455 | ||||
IC50 | 6.05 | J. Med. Chem., (2016) 59:11:5488 | ||||
IC50 | 6.04 | J Med Chem, (2019) 62:7:3171 | ||||
Ki | 8.92 | INHIBITOR | ||||
HDAC10
Histone deacetylase 10
7 Activities
Items per page:
1 – 7 of 7
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 8.68 | J Med Chem, (2019) 62:7:3171 | ||||
IC50 | 8.4 | J. Med. Chem., (2016) 59:4:1455 | ||||
IC50 | 8.35 | J. Med. Chem., (2016) 59:11:5488 | ||||
Ki | 8.29 | Bioorg Med Chem Lett, (2018) 28:17:2985 | ||||
IC50 | 7.99 | J Med Chem, (2020) 63:2:804 | ||||
Ki | 7.51 | J. Med. Chem., (2011) 54:13:4694 | ||||
Ki | 7.51 | INHIBITOR | ||||
HDAC7
Histone deacetylase 7
6 Activities
Items per page:
1 – 6 of 6
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
EC50 | 7.85 | |||||
Ki | 8.64 | J. Med. Chem., (2011) 54:13:4694 | ||||
IC50 | 8.09 | J Med Chem, (2019) 62:7:3171 | ||||
IC50 | 6.28 | J Med Chem, (2020) 63:10:5501 | ||||
Ki | 6.2 | Bioorg Med Chem Lett, (2018) 28:17:2985 | ||||
Ki | 8.64 | INHIBITOR | ||||
HDAC11
Histone deacetylase 11
4 Activities
Items per page:
1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 8.8 | J Med Chem, (2019) 62:7:3171 | ||||
Ki | 8.46 | J. Med. Chem., (2011) 54:13:4694 | ||||
IC50 | 6.92 | J Med Chem, (2020) 63:2:804 | ||||
Ki | 8.46 | INHIBITOR | ||||
BRD4
Bromodomain-containing protein 4
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 8.3 | Bioorg Med Chem Lett, (2017) 27:17:4051 | ||||
IC50 | 8.3 | |||||