Pharos: Illuminating the Druggable Genome

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Ligand Summary

Ligand Structure

chemical structure image

Synonyms & Links

NCATS Inxight: Drugs: 154575

Name: 3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-methoxybenzamide

PubChem: 154575

ChEMBL: CHEMBL42126

LyCHI: 9AKPFQRAM6ST

Target Activities

Items per page:

10

1 – 4 of 4

PDE4B

Tclin

cAMP-specific 3',5'-cyclic phosphodiesterase 4B

5 Activities

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1 – 5 of 5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8.52		J. Med. Chem., (2007) 50:2:344	17228876

IC50	8.7		Bioorg. Med. Chem. Lett., (2010) 20:9:2928	20378348

IC50	9		J. Med. Chem., (1998) 41:3:266	9464356

IC50	9.7		Bioorg. Med. Chem. Lett., (2002) 12:4:653	11844693

IC50	10.39		Bioorg. Med. Chem., (2010) 18:6:2204	20188577

PDE4D

Tclin

cAMP-specific 3',5'-cyclic phosphodiesterase 4D

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8.7		J. Med. Chem., (2007) 50:2:344	17228876

IC50	9.1		J. Med. Chem., (1998) 41:3:266	9464356

IC50	10.68		Bioorg. Med. Chem., (2010) 18:6:2204	20188577

PDE4A

Tclin

cAMP-specific 3',5'-cyclic phosphodiesterase 4A

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8.4		J. Med. Chem., (2007) 50:2:344	17228876

IC50	8.8		J. Med. Chem., (1998) 41:3:266	9464356

PDE4C

Tclin

cAMP-specific 3',5'-cyclic phosphodiesterase 4C

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.85		J. Med. Chem., (2007) 50:2:344	17228876

IC50	8.42		J. Med. Chem., (1998) 41:3:266	9464356