clozapine
Ligand Summary
A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
UNII: J60AR2IKIC
PubChem: 135398737
PubChem: 2818
Guide to Pharmacology: 38
ChEMBL: CHEMBL42
DrugCentral: 722
LyCHI: RKTD5RVPC8UN
Target Activities
333 Activities
Items per page:
10
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