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sotagliflozin

Ligand Summary
Ligand Structure
Rendered image for the query structure
Description
Sotagliflozin is a dual inhibitor of sodium glucose cotransporter type 1 (SGLT1) and SGLT2. Local intestinal inhibition of SGLT1, the major transporter for glucose absorption, delays and reduces glucose absorption in the proximal intestine, resulting in a blunting and delay of postprandial hyperglycaemia. SGLT2 is the predominant transporter responsible for reabsorption of glucose from the glomerular filtrate back into the circulation. By inhibiting SGLT2, sotagliflozin reduces renal reabsorption of filtered glucose and lowers the renal threshold for glucose, and thereby increases urinary glucose excretion
Synonyms & Links
Guide to Pharmacology: 8312
DrugCentral: 5339
LyCHI:  2D3WNDRLVSWV


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Target Activities