CHEMBL279786
Ligand Summary
Name: N*4*-Hydroxy-2-isobutyl-N*1*-(1-methylcarbamoyl-2-phenyl-ethyl)-3-(thiophen-2-ylsulfanylmethyl)-succinamide
PubChem: 5362422
ChEMBL: CHEMBL279786
LyCHI: GY1TXVYFKYK4
Target Activities
MMP1
Interstitial collagenase
8 Activities
Items per page:
1 – 8 of 8
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 9.4 | J. Med. Chem., (1998) 41:8:1209 | ||||
Ki | 9.3 | Bioorg. Med. Chem. Lett., (1995) 5:13:1415 | ||||
IC50 | 9.12 | Bioorg. Med. Chem. Lett., (2001) 11:4:567 | ||||
IC50 | 9 | J. Med. Chem., (2003) 46:16:3514 | ||||
IC50 | 8.92 | Bioorg. Med. Chem. Lett., (1998) 8:22:3251 | ||||
IC50 | 8.59 | Bioorg. Med. Chem. Lett., (1998) 8:1:29 | ||||
IC50 | 8.3 | Bioorg. Med. Chem. Lett., (1997) 7:2:193 | ||||
IC50 | 8.3 | Bioorg. Med. Chem. Lett., (1998) 8:1:23 | ||||
MMP2
72 kDa type IV collagenase
6 Activities
Items per page:
1 – 6 of 6
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 9.3 | Bioorg. Med. Chem. Lett., (2001) 11:4:567 | ||||
IC50 | 9.14 | J. Med. Chem., (2003) 46:16:3514 | ||||
IC50 | 9 | J. Med. Chem., (1998) 41:8:1209 | ||||
IC50 | 8.68 | Bioorg. Med. Chem. Lett., (1998) 8:22:3251 | ||||
IC50 | 8.4 | Bioorg. Med. Chem. Lett., (1997) 7:2:193 | ||||
IC50 | 7.89 | Bioorg. Med. Chem. Lett., (2005) 15:1:181 | ||||
MMP3
Stromelysin-1
5 Activities
Items per page:
1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 9.25 | J. Med. Chem., (2003) 46:16:3514 | ||||
IC50 | 9.19 | J. Med. Chem., (1998) 41:8:1209 | ||||
IC50 | 9.14 | Bioorg. Med. Chem. Lett., (2001) 11:4:567 | ||||
IC50 | 9.12 | Bioorg. Med. Chem. Lett., (1998) 8:22:3251 | ||||
IC50 | 7.7 | Bioorg. Med. Chem. Lett., (1997) 7:2:193 | ||||
MMP14
Matrix metalloproteinase-14
4 Activities
Items per page:
1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.54 | Bioorg. Med. Chem. Lett., (2001) 11:4:567 | ||||
IC50 | 8.52 | J. Med. Chem., (1998) 41:8:1209 | ||||
IC50 | 8.34 | J. Med. Chem., (2003) 46:16:3514 | ||||
IC50 | 7.33 | Bioorg. Med. Chem. Lett., (2005) 15:1:181 | ||||
MMP9
Matrix metalloproteinase-9
4 Activities
Items per page:
1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 9.7 | J. Med. Chem., (1998) 41:8:1209 | ||||
IC50 | 9.22 | J. Med. Chem., (2003) 46:16:3514 | ||||
IC50 | 9.17 | Bioorg. Med. Chem. Lett., (2001) 11:4:567 | ||||
IC50 | 7.6 | Bioorg. Med. Chem. Lett., (2005) 15:1:181 | ||||
FCER2
Low affinity immunoglobulin epsilon Fc receptor
2 Activities
ADAM17
Disintegrin and metalloproteinase domain-containing protein 17
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 9.4 | Med Chem Res, (2011) 20:6:760 | ||||
IC50 | 7.83 | J. Med. Chem., (2003) 46:16:3514 | ||||
MMP7
Matrilysin
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.62 | Bioorg. Med. Chem. Lett., (1998) 8:22:3251 | ||||
IC50 | 8.22 | Bioorg. Med. Chem. Lett., (1997) 7:2:193 | ||||
MMP13
Collagenase 3
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.3 | J. Med. Chem., (2003) 46:16:3514 | ||||