Pharos: Illuminating the Druggable Genome

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Ligand Summary

Ligand Structure

chemical structure image

Synonyms & Links

NCATS Inxight: Drugs: 11497471

Name: N-(3-(3-(dimethylamino)propyl)-5-(trifluoromethyl)phenyl)-4-methyl-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)benzamide

PubChem: 11497471

ChEMBL: CHEMBL221484

LyCHI: YQD8TUM91H4X

Target Activities

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10

1 – 2 of 2

KDR

Tclin

Vascular endothelial growth factor receptor 2

3 Activities

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1 – 3 of 3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8.7		J. Med. Chem., (2007) 50:4:611	17253678

IC50	8.7		Bioorg. Med. Chem. Lett., (2007) 17:10:2886	17350837

IC50	8.7		J. Med. Chem., (2008) 51:6:1649	18324761

TEK

Tclin

Angiopoietin-1 receptor

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	9		J. Med. Chem., (2007) 50:4:611	17253678

IC50	9		Bioorg. Med. Chem. Lett., (2007) 17:10:2886	17350837