dorzolamide
topically effective ocular hypotensive carbonic anhydrase inhibitor; RN refers to mono-HCl (4S-trans)-isomer
Ligand Summary
NCATS Inxight: Drugs: dorzolamide
PubChem: 5284549
Guide to Pharmacology: 6810
ChEMBL: CHEMBL218490
DrugCentral: 949
LyCHI: LWVW9STSSBXL
Target Activities
Items per page:
10
1 – 10 of 11
CA2
Carbonic anhydrase 2
92 Activities
Items per page:
1 – 10 of 92
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 7.37 | J. Med. Chem., (2015) 58:6:2821 | ||||
Ki | 7.6 | Bioorg. Med. Chem., (2015) 23:13:3592 | ||||
Ki | 8.04 | Bioorg. Med. Chem., (2013) 21:22:7210 | ||||
Ki | 8.05 | Bioorg. Med. Chem. Lett., (2001) 11:13:1787 | ||||
Ki | 8.05 | Bioorg. Med. Chem. Lett., (2003) 13:17:2867 | ||||
Ki | 8.05 | Bioorg. Med. Chem. Lett., (2004) 14:1:225 | ||||
Ki | 8.05 | Bioorg. Med. Chem. Lett., (2004) 14:9:2351 | ||||
Ki | 8.05 | J. Med. Chem., (2006) 49:24:7024 | ||||
Ki | 8.05 | Bioorg. Med. Chem. Lett., (2008) 18:8:2669 | ||||
Ki | 8.05 | Bioorg. Med. Chem., (2007) 15:13:4336 | ||||
CA9
Carbonic anhydrase 9
28 Activities
Items per page:
1 – 10 of 28
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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Ki | 7.28 | Bioorg. Med. Chem. Lett., (2004) 14:9:2351 | ||||
Ki | 7.28 | J. Med. Chem., (2006) 49:24:7024 | ||||
Ki | 7.28 | Bioorg. Med. Chem. Lett., (2008) 18:8:2669 | ||||
Ki | 7.28 | Bioorg. Med. Chem., (2007) 15:13:4336 | ||||
IC50 | 7.28 | J. Med. Chem., (2004) 47:3:550 | ||||
Ki | 7.28 | Bioorg. Med. Chem. Lett., (2004) 14:14:3757 | ||||
Ki | 7.28 | Bioorg. Med. Chem. Lett., (2004) 14:21:5427 | ||||
Ki | 7.28 | J. Med. Chem., (2005) 48:6:2121 | ||||
Ki | 7.28 | Bioorg. Med. Chem. Lett., (2005) 15:12:3102 | ||||
Ki | 7.28 | Bioorg. Med. Chem., (2013) 21:22:7210 | ||||
CA12
Carbonic anhydrase 12
18 Activities
Items per page:
1 – 10 of 18
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 8.46 | J. Med. Chem., (2006) 49:24:7024 | ||||
Ki | 8.46 | Bioorg. Med. Chem. Lett., (2008) 18:8:2669 | ||||
Ki | 8.46 | Bioorg. Med. Chem., (2007) 15:13:4336 | ||||
Ki | 8.46 | Bioorg. Med. Chem., (2013) 21:22:7210 | ||||
Ki | 8.46 | Bioorg. Med. Chem. Lett., (2005) 15:17:3821 | ||||
Ki | 8.46 | Bioorg. Med. Chem. Lett., (2005) 15:4:963 | ||||
Ki | 8.46 | Bioorg. Med. Chem. Lett., (2005) 15:17:3828 | ||||
Ki | 8.46 | J. Med. Chem., (2009) 52:19:5990 | ||||
Ki | 8.46 | Bioorg. Med. Chem., (2013) 21:19:5973 | ||||
Ki | 8.46 | Bioorg. Med. Chem., (2014) 22:5:1586 | ||||
CA7
Carbonic anhydrase 7
9 Activities
Items per page:
1 – 9 of 9
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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Ki | 8.46 | J. Med. Chem., (2006) 49:24:7024 | ||||
Ki | 8.46 | Bioorg. Med. Chem. Lett., (2008) 18:8:2669 | ||||
Ki | 8.46 | Bioorg. Med. Chem., (2007) 15:13:4336 | ||||
Ki | 8.46 | Bioorg. Med. Chem., (2013) 21:22:7210 | ||||
Ki | 8.46 | Bioorg. Med. Chem. Lett., (2005) 15:4:971 | ||||
Ki | 8.46 | J. Med. Chem., (2009) 52:19:5990 | ||||
Ki | 8.46 | Bioorg. Med. Chem., (2013) 21:17:5168 | ||||
Ki | 8.46 | Bioorg. Med. Chem., (2013) 21:19:5973 | ||||
Ki | 8.46000004 | |||||
CA14
Carbonic anhydrase 14
8 Activities
Items per page:
1 – 8 of 8
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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Ki | 7.57 | J. Med. Chem., (2006) 49:24:7024 | ||||
Ki | 7.57 | Bioorg. Med. Chem. Lett., (2008) 18:8:2669 | ||||
Ki | 7.57 | Bioorg. Med. Chem., (2007) 15:13:4336 | ||||
Ki | 7.57 | Bioorg. Med. Chem., (2013) 21:22:7210 | ||||
Ki | 7.57 | Bioorg. Med. Chem. Lett., (2005) 15:17:3828 | ||||
Ki | 7.57 | J. Med. Chem., (2009) 52:19:5990 | ||||
Ki | 7.57 | Bioorg. Med. Chem. Lett., (2007) 17:4:987 | ||||
Ki | 7.82000017 | |||||
CA6
Carbonic anhydrase 6
7 Activities
Items per page:
1 – 7 of 7
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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Ki | 7.98 | Bioorg. Med. Chem., (2013) 21:22:7210 | ||||
Ki | 8 | Bioorg. Med. Chem. Lett., (2008) 18:8:2669 | ||||
Ki | 8 | Bioorg. Med. Chem., (2007) 15:13:4336 | ||||
Ki | 8 | J. Med. Chem., (2009) 52:19:5990 | ||||
Ki | 8 | J. Med. Chem., (2007) 50:2:381 | ||||
Ki | 8 | J. Med. Chem., (2009) 52:3:646 | ||||
Ki | 8 | Bioorg. Med. Chem. Lett., (2011) 21:2:710 | ||||
CA5B
Carbonic anhydrase 5B, mitochondrial
5 Activities
Items per page:
1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 7.48 | J. Med. Chem., (2006) 49:24:7024 | ||||
Ki | 7.48 | Bioorg. Med. Chem. Lett., (2008) 18:8:2669 | ||||
Ki | 7.48 | Bioorg. Med. Chem., (2007) 15:13:4336 | ||||
Ki | 7.48 | J. Med. Chem., (2009) 52:19:5990 | ||||
Ki | 7.48 | J. Med. Chem., (2005) 48:24:7860 | ||||
CA5A
Carbonic anhydrase 5A, mitochondrial
5 Activities
Items per page:
1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 7.38 | J. Med. Chem., (2006) 49:24:7024 | ||||
Ki | 7.38 | Bioorg. Med. Chem. Lett., (2008) 18:8:2669 | ||||
Ki | 7.38 | Bioorg. Med. Chem., (2007) 15:13:4336 | ||||
Ki | 7.38 | J. Med. Chem., (2009) 52:19:5990 | ||||
Ki | 7.38 | J. Med. Chem., (2005) 48:24:7860 | ||||
CA1
Carbonic anhydrase 1
4 Activities
Items per page:
1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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Ki | 6.3 | Bioorg. Med. Chem. Lett., (2007) 17:18:5032 | ||||
Ki | 6.3 | J. Med. Chem., (2008) 51:6:1945 | ||||
Ki | 6.3 | Bioorg. Med. Chem. Lett., (2009) 19:8:2273 | ||||
Ki | 4.30000019 | |||||