forodesine
Ligand Summary
Forodesine is a transition state analogue that binds preferentially to and inhibits purine nucleotide phosphorylase (PNP), resulting in the accumulation of deoxyguanosine triphosphate and the subsequent inhibition of the enzyme ribonucleoside diphosphate reductase and DNA synthesis. This agent selectively causes apoptosis in stimulated or malignant T-lymphocytes. A transition state analogue is a substrate designed to mimic the properties or the geometry of the transition state of reaction.
UNII: 426X066ELK
PubChem: 135409409
PubChem: 444499
Guide to Pharmacology: 8272
ChEMBL: CHEMBL218291
DrugCentral: 5229
LyCHI: QYQSUK18RAVS
Target Activities
18 Activities
Items per page:
10
1 – 10 of 18
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