You are using an outdated browser. Please upgrade your browser to improve your experience.

forodesine

Ligand Summary
Ligand Structure
Rendered image for the query structure
Description
Forodesine is a transition state analogue that binds preferentially to and inhibits purine nucleotide phosphorylase (PNP), resulting in the accumulation of deoxyguanosine triphosphate and the subsequent inhibition of the enzyme ribonucleoside diphosphate reductase and DNA synthesis. This agent selectively causes apoptosis in stimulated or malignant T-lymphocytes. A transition state analogue is a substrate designed to mimic the properties or the geometry of the transition state of reaction.
Synonyms & Links
Guide to Pharmacology: 8272
DrugCentral: 5229
LyCHI:  QYQSUK18RAVS


Target Activities