ibrutinib
Ligand Summary
Ibrutinib is a small-molecule inhibitor of BTK. Ibrutinib forms a covalent bond with a cysteine residue in the BTK active site, leading to inhibition of BTK enzymatic activity. BTK is a signaling molecule of the B-cell antigen receptor (BCR) and cytokine receptor pathways. BTK's role in signaling through the B-cell surface receptors results in activation of pathways necessary for B-cell trafficking, chemotaxis, and adhesion. Nonclinical studies show that ibrutinib inhibits malignant B-cell proliferation and survival in vivo as well as cell migration and substrate adhesion in vitro.
UNII: 1X70OSD4VX
PubChem: 24821094
Guide to Pharmacology: 6912
ChEMBL: CHEMBL1873475
DrugCentral: 4810
LyCHI: 8GKRMF7RW153
Target Activities
215 Activities
Items per page:
10
1 – 10 of 215
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