fluticasone furoate
Ligand Summary
Fluticasone furoate is a synthetic trifluorinated corticosteroid with anti‑inflammatory activity. Fluticasone furoate has been shown in vitro to exhibit a binding affinity for the human glucocorticoid receptor. The precise mechanism of corticosteroid action on asthma is not known. Inflammation is an important component in the pathogenesis of asthma. Corticosteroids have been shown to have a wide range of actions on multiple cell types (e.g., mast cells, eosinophils, neutrophils, macrophages, lymphocytes) and mediators (e.g., histamine, eicosanoids, leukotrienes, cytokines) involved in inflammation. These anti-inflammatory actions of corticosteroids contribute to their efficacy in asthma.
UNII: JS86977WNV
PubChem: 9854489
ChEMBL: CHEMBL1676
DrugCentral: 4554
LyCHI: 1DR8DSQNL55C
Target Activities
7 Activities
Items per page:
10
1 – 7 of 7
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | ||||||
EC50 | ||||||
EC50 | ||||||
Ki | ||||||
IC50 | ||||||
IC50 | ||||||
IC50 | AGONIST | |||||