selumetinib
Ligand Summary
Selumetinib is an inhibitor of mitogen-activated protein kinase kinases 1 and 2 (MEK1/2). MEK1/2 proteins are upstream regulators of the extracellular signal-related kinase (ERK) pathway. Both MEK and ERK are critical components of the RAS-regulated RAF-MEK-ERK pathway, which is often activated in different types of cancers
UNII: 6UH91I579U
PubChem: 10127622
ChEMBL: CHEMBL1614701
DrugCentral: 5388
LyCHI: T5L9Y2W2CV11
Target Activities
10 Activities
Items per page:
10
1 – 10 of 10
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | ||||||
IC50 | ||||||
Kd | ||||||
Kd | ||||||
Kd | ||||||
IC50 | INHIBITOR | |||||
IC50 | INHIBITOR | |||||
Kd | ||||||
Kd | ||||||
Kd | ||||||