Pharos: Illuminating the Druggable Genome

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Ligand Summary

Ligand Structure

chemical structure image

Synonyms & Links

NCATS Inxight: Drugs: 44607530

Name: N-(3-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide

PubChem: 44607530

Guide to Pharmacology: 9176

ChEMBL: CHEMBL1229592

LyCHI: B4ZGNKLVH7ZZ

Target Activities

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EGFR

Tclin

Epidermal growth factor receptor

9 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.8		Bioorg. Med. Chem., (2015) 23:12:2767	25975640

IC50	8		J. Med. Chem., (2015) 58:17:6844	26275028

IC50	8.19		MedChemComm, (2012) 3:9:1155

IC50	8.21		J. Med. Chem., (2012) 55:6:2711	22339342

IC50	8.36		Eur. J. Med. Chem., (2014) 77:None:75	24607591

IC50	8.49		J. Med. Chem., (2013) 56:11:4738	23668441

IC50	8.49		Eur. J. Med. Chem., (2013) 66:None:82	23792318

IC50	8.67		J. Med. Chem., (2013) 56:20:7821	24053674

Kd	7.34000015			20033049

BLK

Tchem

Tyrosine-protein kinase Blk

1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	6.69999981			20033049

BTK

Tclin

Tyrosine-protein kinase BTK

1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.36999989			20033049

ERBB4

Tclin

Receptor tyrosine-protein kinase erbB-4

1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.55000019			20033049

ITK

Tclin

Tyrosine-protein kinase ITK/TSK

1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.36999989			20033049

NUAK1

Tchem

NUAK family SNF1-like kinase 1

1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	7.03999996			20033049