CHEMBL1229592
Ligand Summary
NCATS Inxight: Drugs: 44607530
Name: N-(3-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide
PubChem: 44607530
Guide to Pharmacology: 9176
ChEMBL: CHEMBL1229592
LyCHI: B4ZGNKLVH7ZZ
Target Activities
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EGFR
Epidermal growth factor receptor
9 Activities
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1 – 9 of 9
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 7.8 | Bioorg. Med. Chem., (2015) 23:12:2767 | ||||
IC50 | 8 | J. Med. Chem., (2015) 58:17:6844 | ||||
IC50 | 8.19 | MedChemComm, (2012) 3:9:1155 | ||||
IC50 | 8.21 | J. Med. Chem., (2012) 55:6:2711 | ||||
IC50 | 8.36 | Eur. J. Med. Chem., (2014) 77:None:75 | ||||
IC50 | 8.49 | J. Med. Chem., (2013) 56:11:4738 | ||||
IC50 | 8.49 | Eur. J. Med. Chem., (2013) 66:None:82 | ||||
IC50 | 8.67 | J. Med. Chem., (2013) 56:20:7821 | ||||
Kd | 7.34000015 | |||||
BLK
Tyrosine-protein kinase Blk
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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Kd | 6.69999981 | |||||
BTK
Tyrosine-protein kinase BTK
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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Kd | 7.36999989 | |||||
ERBB4
Receptor tyrosine-protein kinase erbB-4
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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Kd | 7.55000019 | |||||
ITK
Tyrosine-protein kinase ITK/TSK
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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Kd | 7.36999989 | |||||
NUAK1
NUAK family SNF1-like kinase 1
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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Kd | 7.03999996 | |||||