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pitavastatin

Ligand Summary
Ligand Structure
Rendered image for the query structure
Description
Pitavastatin competitively inhibits HMG-CoA reductase, which is a rate-determining enzyme involved with biosynthesis of cholesterol, in a manner of competition with the substrate so that it inhibits cholesterol synthesis in the liver. As a result, the expression of LDL-receptors followed by the uptake of LDL from blood to liver is accelerated and then the plasma TC decreases. Further, the sustained inhibition of cholesterol synthesis in the liver decreases levels of very low density lipoproteins.
Synonyms & Links
Guide to Pharmacology: 3035
DrugCentral: 2214
LyCHI:  RTMTULW5J4AQ


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Target Activities