rucaparib
Ligand Summary
Rucaparib is an inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, including PARP-1, PARP-2, and PARP-3, which play a role in DNA repair. In vitro studies have shown that rucaparib-induced cytotoxicity may involve inhibition of PARP enzymatic activity and increased formation of PARP-DNA complexes resulting in DNA damage, apoptosis, and cell death. Increased rucaparib-induced cytotoxicity was observed in tumor cell lines with deficiencies in BRCA1/2 and other DNA repair genes. Rucaparib has been shown to decrease tumor growth in mouse xenograft models of human cancer with or without deficiencies in BRCA.
UNII: 8237F3U7EH
PubChem: 9931954
Guide to Pharmacology: 7736
ChEMBL: CHEMBL1173055
DrugCentral: 5203
LyCHI: 7AGVRT34WGZ2
Target Activities
46 Activities
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