norethisterone
Ligand Summary
A synthetic progestational hormone with actions similar to those of PROGESTERONE but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties. The hormone has been used in treating amenorrhea, functional uterine bleeding, endometriosis, and for CONTRACEPTION.
UNII: T18F433X4S
PubChem: 6230
Guide to Pharmacology: 2880
ChEMBL: CHEMBL1162
DrugCentral: 1962
LyCHI: Q5HCG6PQT3QD
Target Activities
PGR
Progesterone receptor
6 Activities
Items per page:
1 – 6 of 6
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
EC50 | 8.66 | |||||
Kd | 9.4 | J. Med. Chem., (2004) 47:13:3381 | ||||
Ki | 8.73 | J. Med. Chem., (1998) 41:3:303 | ||||
EC50 | 8.66 | J. Med. Chem., (1998) 41:3:303 | ||||
IC50 | 8.49 | J. Med. Chem., (1995) 38:25:4880 | ||||
ED50 | 11.26 | AGONIST | ||||
SHBG
Sex hormone-binding globulin
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Kd | 7.97 | J. Med. Chem., (2008) 51:7:2047 | ||||
Kd | 7.97 | |||||