migalastat
Ligand Summary
Migalastat is a pharmacological chaperone that is designed to selectively and reversibly bind with high affinity to the active sites of certain mutant forms of alpha-Gal A, the genotypes of which are referred to as amenable mutations. Migalastat binding stabilizes these mutant forms of alpha-Gal A in the endoplasmic reticulum and facilitates their proper trafficking to lysosomes where dissociation of migalastat restores alpha-Gal A activity, leading to the catabolism of GL-3 and related substrates.
UNII: C4XNY919FW
PubChem: 176077
Guide to Pharmacology: 10200
ChEMBL: CHEMBL110458
DrugCentral: 5110
LyCHI: Y1A2RHTFZYAL
Target Activities
8 Activities
Items per page:
10
1 – 8 of 8
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IC50 | PHARMACOLOGICAL CHAPERONE | |||||
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