Pharos : Ligand Details

Target Activities

Explore Associated and Predicted Targets

CYP1A1

Tchem

Cytochrome P450 1A1

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	6.2	Bioorg. Med. Chem., (2010) 18:17:6310	20696580

Ki	6.12	Bioorg. Med. Chem., (2011) 19:9:2842	21482471

HSD17B2

Tchem

Estradiol 17-beta-dehydrogenase 2

2 Activities

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Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	6.44	J. Med. Chem., (2008) 51:14:4188	18533708

IC50	6.44	J Nat Prod, (2017) 80:4:965	28319389

CYP1A2

Tchem

Cytochrome P450 1A2

2 Activities

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Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
AC50	7.1	None, None:None:None

IC50	6.14	Bioorg. Med. Chem., (2010) 18:17:6310	20696580

CYP1B1

Tchem

Cytochrome P450 1B1

2 Activities

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Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	7.37	Bioorg. Med. Chem., (2011) 19:9:2842	21482471

IC50	7.33	Bioorg. Med. Chem., (2010) 18:17:6310	20696580

CA7

Tclin

Carbonic anhydrase 7

1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.6		Bioorg. Med. Chem., (2015) 23:22:7219	26498393

DPP4

Tclin

Dipeptidyl peptidase 4

1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.31		Eur J Med Chem, (2018) 151:None:145	29609120

TYR

Tclin

Tyrosinase

1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6		J. Nat. Prod., (2016) 79:2:281	26841168

AHR

Tchem

Aryl hydrocarbon receptor

1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.55		Bioorg. Med. Chem., (2007) 15:15:5047	17544277

CA12

Tclin

Carbonic anhydrase 12

1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	6.84		Bioorg. Med. Chem., (2015) 23:22:7219	26498393

CYP2C9

Tchem

Cytochrome P450 2C9

1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
AC50	8.9		None, None:None:None

TRPC5

Tchem

Short transient receptor potential channel 5

1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	5.41		J Med Chem, (2019) 62:17:7589	30943030

CISD1

Tchem

CDGSH iron-sulfur domain-containing protein 1

1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	6.88		Bioorg Med Chem Lett, (2016) 26:21:5350	27687671