CHEMBL440498
Ligand Summary
Name: 4-[4-(4-Chloro-phenoxy)-benzenesulfonylmethyl]-tetrahydro-pyran-4-carboxylic acid hydroxyamide
PubChem: 3342298
ChEMBL: CHEMBL440498
LyCHI: BLN4DQU8ZC2D
Target Activities
MMP13
Collagenase 3
11 Activities
Items per page:
1 – 10 of 11
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 11 | J. Med. Chem., (2014) 57:21:8886 | ||||
IC50 | 11 | Bioorg Med Chem, (2016) 24:23:6149 | ||||
IC50 | 11 | J Med Chem, (2017) 60:2:608 | ||||
Ki | 9.55 | J. Med. Chem., (2009) 52:11:3523 | ||||
IC50 | 9.52 | J. Med. Chem., (2009) 52:11:3523 | ||||
Ki | 9.28 | J. Med. Chem., (2000) 43:3:305 | ||||
Ki | 9.28 | Bioorg. Med. Chem. Lett., (2005) 15:4:1101 | ||||
IC50 | 9.22 | Bioorg. Med. Chem. Lett., (2000) 10:24:2815 | ||||
IC50 | 8.7 | J. Med. Chem., (2003) 46:12:2376 | ||||
IC50 | 8.7 | J. Med. Chem., (2009) 52:11:3523 | ||||
MMP2
72 kDa type IV collagenase
8 Activities
Items per page:
1 – 8 of 8
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 10.54 | J. Med. Chem., (2014) 57:21:8886 | ||||
IC50 | 10.54 | Bioorg. Med. Chem., (2014) 22:19:5487 | ||||
IC50 | 10.54 | Bioorg Med Chem, (2016) 24:23:6149 | ||||
IC50 | 10.54 | J Med Chem, (2017) 60:2:608 | ||||
Ki | 9.66 | J. Med. Chem., (2000) 43:3:305 | ||||
Ki | 9.66 | Bioorg. Med. Chem. Lett., (2005) 15:4:1101 | ||||
IC50 | 9.52 | J. Med. Chem., (2009) 52:11:3523 | ||||
IC50 | 9.4 | Bioorg. Med. Chem. Lett., (2000) 10:24:2815 | ||||
MMP1
Interstitial collagenase
8 Activities
Items per page:
1 – 8 of 8
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 7.47 | J. Med. Chem., (2014) 57:21:8886 | ||||
IC50 | 7.47 | Bioorg. Med. Chem., (2014) 22:19:5487 | ||||
IC50 | 7.47 | J Med Chem, (2017) 60:2:608 | ||||
IC50 | 6.63 | J. Med. Chem., (2003) 46:12:2376 | ||||
IC50 | 6.45 | J. Med. Chem., (2009) 52:11:3523 | ||||
Ki | 6.23 | J. Med. Chem., (2000) 43:3:305 | ||||
Ki | 6.23 | Bioorg. Med. Chem. Lett., (2005) 15:4:1101 | ||||
IC50 | 6.1 | Bioorg. Med. Chem. Lett., (2000) 10:24:2815 | ||||
MMP9
Matrix metalloproteinase-9
7 Activities
Items per page:
1 – 7 of 7
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 9.96 | J. Med. Chem., (2014) 57:21:8886 | ||||
IC50 | 9.96 | Bioorg. Med. Chem., (2014) 22:19:5487 | ||||
IC50 | 9.96 | J Med Chem, (2017) 60:2:608 | ||||
Ki | 9.26 | Bioorg. Med. Chem. Lett., (2005) 15:4:1101 | ||||
Ki | 9.24 | J. Med. Chem., (2000) 43:3:305 | ||||
IC50 | 8.7 | J. Med. Chem., (2009) 52:11:3523 | ||||
IC50 | 8.52 | J. Med. Chem., (2003) 46:12:2376 | ||||
MMP3
Stromelysin-1
6 Activities
Items per page:
1 – 6 of 6
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 9.52 | J. Med. Chem., (2014) 57:21:8886 | ||||
IC50 | 9.52 | Bioorg. Med. Chem., (2014) 22:19:5487 | ||||
IC50 | 9.52 | J Med Chem, (2017) 60:2:608 | ||||
IC50 | 8.15 | J. Med. Chem., (2009) 52:11:3523 | ||||
Ki | 8.03 | J. Med. Chem., (2000) 43:3:305 | ||||
Ki | 8.03 | Bioorg. Med. Chem. Lett., (2005) 15:4:1101 | ||||
ADAM17
Disintegrin and metalloproteinase domain-containing protein 17
5 Activities
Items per page:
1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 7.85 | J. Med. Chem., (2014) 57:21:8886 | ||||
IC50 | 7.85 | Bioorg. Med. Chem., (2014) 22:19:5487 | ||||
IC50 | 7.85 | J Med Chem, (2017) 60:2:608 | ||||
IC50 | 6.75 | J. Med. Chem., (2003) 46:12:2376 | ||||
IC50 | 6.36 | J. Med. Chem., (2009) 52:11:3523 | ||||
MMP14
Matrix metalloproteinase-14
4 Activities
Items per page:
1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 8.96 | J. Med. Chem., (2014) 57:21:8886 | ||||
IC50 | 8.96 | Bioorg. Med. Chem., (2014) 22:19:5487 | ||||
IC50 | 8.96 | J Med Chem, (2017) 60:2:608 | ||||
IC50 | 7.85 | J. Med. Chem., (2009) 52:11:3523 | ||||
MMP10
Stromelysin-2
4 Activities
Items per page:
1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 9.27 | J. Med. Chem., (2014) 57:21:8886 | ||||
IC50 | 9.27 | Bioorg. Med. Chem., (2014) 22:19:5487 | ||||
IC50 | 9.27 | Bioorg Med Chem, (2016) 24:23:6149 | ||||
IC50 | 9.27 | J Med Chem, (2017) 60:2:608 | ||||
MMP8
Neutrophil collagenase
4 Activities
Items per page:
1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 10.01 | J. Med. Chem., (2014) 57:21:8886 | ||||
IC50 | 10.01 | Bioorg. Med. Chem., (2014) 22:19:5487 | ||||
IC50 | 10.01 | Bioorg Med Chem, (2016) 24:23:6149 | ||||
IC50 | 10.01 | J Med Chem, (2017) 60:2:608 | ||||