Pharos : Ligand Details - B3JV9SPJ1CH8

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Ligand Summary

Ligand Structure

chemical structure image

Synonyms & Links

Name: N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-N-(2,2,2-trifluoroethyl)benzenesulfonamide

PubChem: 447912

Guide to Pharmacology: 2755

ChEMBL: CHEMBL62136

LyCHI: B3JV9SPJ1CH8

Target Activities

NR1H3

Tchem

Oxysterols receptor LXR-alpha

26 Activities

Items per page:

1 – 10 of 26

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7		Bioorg. Med. Chem. Lett., (2012) 22:7:2407	22406115

Kd	7.03		Bioorg. Med. Chem. Lett., (2013) 23:14:4185	23769638

EC50	7.04		Bioorg. Med. Chem. Lett., (2013) 23:14:4185	23769638

EC50	7.07		J. Med. Chem., (2002) 45:10:1963	11985463

IC50	7.12		J. Med. Chem., (2008) 51:18:5758	18800767

EC50	7.2		J. Med. Chem., (2010) 53:8:3412	20345102

EC50	7.22		J. Med. Chem., (2002) 45:10:1963	11985463

EC50	7.26		J. Med. Chem., (2005) 48:17:5419	16107141

IC50	7.52		Bioorg. Med. Chem. Lett., (2006) 16:19:5231	16876993

EC50	7.52		Bioorg. Med. Chem. Lett., (2015) 25:18:3914	26238323

NR1H2

Tchem

Oxysterols receptor LXR-beta

22 Activities

Items per page:

1 – 10 of 22

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
EC50	7		J. Med. Chem., (2010) 53:8:3412	20345102

IC50	7		Bioorg. Med. Chem. Lett., (2012) 22:7:2407	22406115

EC50	7.07		Bioorg. Med. Chem. Lett., (2014) 24:22:5265	25305688

IC50	7.16		Bioorg. Med. Chem. Lett., (2006) 16:19:5231	16876993

EC50	7.18		ACS Med. Chem. Lett., (2015) 6:8:902	26288691

EC50	7.52		J. Med. Chem., (2005) 48:17:5419	16107141

IC50	7.52		J. Med. Chem., (2008) 51:18:5758	18800767

IC50	7.7		J. Med. Chem., (2010) 53:8:3412	20345102

EC50	7.7		J. Med. Chem., (2016) 59:7:3489	27011007

Ki	7.77		Bioorg Med Chem Lett, (2016) 26:20:5044	27599745

RORC

Tchem

Nuclear receptor ROR-gamma

6 Activities

Items per page:

1 – 6 of 6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.22		Bioorg. Med. Chem. Lett., (2013) 23:24:6604	24239186

IC50	7.22		J. Med. Chem., (2014) 57:14:5871	24502334

EC50	7.27		Bioorg. Med. Chem. Lett., (2013) 23:24:6604	24239186

EC50	7.27		J. Med. Chem., (2014) 57:14:5871	24502334

Ki	7.29		MedChemComm, (2013) 4:5:764

Ki	7.29		J. Med. Chem., (2014) 57:14:5871	24502334

NR1I2

Tchem

Nuclear receptor subfamily 1 group I member 2

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.4		Bioorg. Med. Chem., (2007) 15:5:2156	17215127

EC50	7.44		Bioorg. Med. Chem. Lett., (2013) 23:24:6604	24239186

EC50	7.44		J. Med. Chem., (2014) 57:14:5871	24502334