Pharos : Ligand Details - B3JV9SPJ1CH8

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Ligand Summary

Ligand Structure

Rendered image for the query structure

Synonyms & Links

Name: Tularik

PubChem: 447912

Guide to Pharmacology: 2755

ChEMBL: CHEMBL62136

LyCHI: B3JV9SPJ1CH8

Target Activities

Explore Associated and Predicted Targets

NR1H2

Tchem

Oxysterols receptor LXR-beta

38 Activities

Items per page:

1 – 10 of 38

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
	7.3			11090131

EC50	8.33		J. Med. Chem., (2011) 54:3:788	21218783

EC50	8.1		Bioorg. Med. Chem. Lett., (2009) 19:7:2009	19264481

IC50	8.05		Bioorg. Med. Chem. Lett., (2008) 18:1:54	18023179

IC50	8.05		J. Med. Chem., (2008) 51:22:7161	18973288

IC50	8.05		Bioorg. Med. Chem., (2009) 17:23:8086	19853462

IC50	8.05		Bioorg. Med. Chem. Lett., (2010) 20:2:689	19962892

IC50	8.05		J. Med. Chem., (2010) 53:8:3296	20350005

IC50	8.05		Bioorg. Med. Chem. Lett., (2010) 20:9:2903	20382019

IC50	8		J. Med. Chem., (2006) 49:21:6151	17034119

NR1H3

Tchem

Oxysterols receptor LXR-alpha

33 Activities

Items per page:

1 – 10 of 33

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
	7.3			11090131

EC50	8.49		J. Med. Chem., (2011) 54:3:788	21218783

EC50	8.22		Bioorg Med Chem Lett, (2018) 28:4:796	29398545

IC50	8.05		Bioorg. Med. Chem. Lett., (2010) 20:1:209	19932617

IC50	8.05		Bioorg. Med. Chem. Lett., (2010) 20:2:521	20005711

IC50	8.05		Bioorg. Med. Chem. Lett., (2010) 20:2:526	20006495

EC50	8		Bioorg. Med. Chem. Lett., (2006) 16:6:1638	16386417

IC50	8		J. Med. Chem., (2006) 49:21:6151	17034119

EC50	8		Bioorg. Med. Chem. Lett., (2009) 19:7:2009	19264481

IC50	7.89		Bioorg. Med. Chem. Lett., (2008) 18:1:54	18023179

NR1I2

Tchem

Nuclear receptor subfamily 1 group I member 2

7 Activities

Items per page:

1 – 7 of 7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
EC50	8.1		Bioorg Med Chem Lett, (2018) 28:2:85	29233651

EC50	7.9		Bioorg. Med. Chem., (2007) 15:5:2156	17215127

EC50	7.82		J Med Chem, (2020) 63:7:3701	32160459

EC50	7.44		Bioorg. Med. Chem. Lett., (2013) 23:24:6604	24239186

EC50	7.44		J. Med. Chem., (2014) 57:14:5871	24502334

IC50	7.4		Bioorg. Med. Chem., (2007) 15:5:2156	17215127

EC50	7.3		ACS Med Chem Lett, (2019) 10:4:677	30996817

RORC

Tchem

Nuclear receptor ROR-gamma

6 Activities

Items per page:

1 – 6 of 6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.29		MedChemComm, (2013) 4:5:764

Ki	7.29		J. Med. Chem., (2014) 57:14:5871	24502334

EC50	7.27		Bioorg. Med. Chem. Lett., (2013) 23:24:6604	24239186

EC50	7.27		J. Med. Chem., (2014) 57:14:5871	24502334

IC50	7.22		Bioorg. Med. Chem. Lett., (2013) 23:24:6604	24239186

IC50	7.22		J. Med. Chem., (2014) 57:14:5871	24502334