Pharos : Ligand Details

Target Activities

HDAC1

Tclin

Histone deacetylase 1

9 Activities

Items per page:

1 – 9 of 9

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.2	J. Med. Chem., (2011) 54:13:4694	21634430

IC50	7.32	Eur J Med Chem, (2016) 122:None:92	27344487

Ki	7.58	J. Med. Chem., (2011) 54:13:4694	21634430

IC50	7.75	Bioorg. Med. Chem. Lett., (2008) 18:6:1814	18308563

IC50	7.82	Bioorg. Med. Chem. Lett., (2011) 21:16:4909	21742496

Ki	9.05	Bioorg. Med. Chem., (2015) 23:16:5151	25637120

Ki	9.07	Nat. Chem. Biol., (2010) 6:3:238	20139990

EC50	7.38999987		17868033

Ki	9.06999969		20139990

HDAC6

Tclin

Histone deacetylase 6

7 Activities

Items per page:

1 – 7 of 7

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.3	Eur J Med Chem, (2016) 122:None:92	27344487

IC50	7.82	Bioorg. Med. Chem. Lett., (2008) 18:6:1814	18308563

Ki	8	J. Med. Chem., (2011) 54:13:4694	21634430

Ki	8.8	Bioorg. Med. Chem., (2015) 23:16:5151	25637120

Ki	8.8	Nat. Chem. Biol., (2010) 6:3:238	20139990

Ki	8.80000019		20139990

EC50	7.09000015		17868033

HDAC2

Tclin

Histone deacetylase 2

6 Activities

Items per page:

1 – 6 of 6

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.31	Eur J Med Chem, (2016) 122:None:92	27344487

Ki	7.66	J. Med. Chem., (2011) 54:13:4694	21634430

Ki	9.05	Bioorg. Med. Chem., (2015) 23:16:5151	25637120

Ki	9.07	Nat. Chem. Biol., (2010) 6:3:238	20139990

Ki	9.06999969		20139990

EC50	6.9000001		17868033

HDAC3

Tclin

Histone deacetylase 3

6 Activities

Items per page:

1 – 6 of 6

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	7.34	Bioorg. Med. Chem. Lett., (2008) 18:6:1814	18308563

Ki	7.72	J. Med. Chem., (2011) 54:13:4694	21634430

Ki	8.82	Bioorg. Med. Chem., (2015) 23:16:5151	25637120

Ki	8.82	Nat. Chem. Biol., (2010) 6:3:238	20139990

EC50	7.51999998		17868033

Ki	8.81999969		20139990

HDAC8

Tclin

Histone deacetylase 8

6 Activities

Items per page:

1 – 6 of 6

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	6.7	Eur J Med Chem, (2016) 122:None:92	27344487

Ki	7.6	Bioorg. Med. Chem., (2015) 23:16:5151	25637120

Ki	7.6	Nat. Chem. Biol., (2010) 6:3:238	20139990

Ki	7.66	J. Med. Chem., (2011) 54:13:4694	21634430

EC50	6.67000008		17868033

Ki	7.5999999		20139990

HDAC9

Tclin

Histone deacetylase 9

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	6.6	Bioorg. Med. Chem., (2015) 23:16:5151	25637120

Ki	6.6	Nat. Chem. Biol., (2010) 6:3:238	20139990

Ki	7.62	J. Med. Chem., (2011) 54:13:4694	21634430

EC50	6.88999987		17868033

Ki	6.5999999		20139990

HDAC4

Tclin

Histone deacetylase 4

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	6.42	Bioorg. Med. Chem., (2015) 23:16:5151	25637120

Ki	6.42	Nat. Chem. Biol., (2010) 6:3:238	20139990

Ki	7.82	J. Med. Chem., (2011) 54:13:4694	21634430

Ki	6.42000008		20139990

EC50	6.94000006		17868033

HDAC7

Tclin

Histone deacetylase 7

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	7.12	Bioorg. Med. Chem., (2015) 23:16:5151	25637120

Ki	7.12	Nat. Chem. Biol., (2010) 6:3:238	20139990

Ki	7.29	J. Med. Chem., (2011) 54:13:4694	21634430

EC50	7.17000008		17868033

Ki	7.11999989		20139990

HDAC5

Tclin

Histone deacetylase 5

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	6.76	Bioorg. Med. Chem., (2015) 23:16:5151	25637120

Ki	6.76	Nat. Chem. Biol., (2010) 6:3:238	20139990

Ki	7.6	J. Med. Chem., (2011) 54:13:4694	21634430

Ki	6.76000023		20139990

HDAC10

Tclin

Histone deacetylase 10

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.23		J. Med. Chem., (2011) 54:13:4694	21634430

HDAC11

Tclin

Histone deacetylase 11

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.57		J. Med. Chem., (2011) 54:13:4694	21634430