Pharos : Ligand Details

Target Activities

Explore Associated and Predicted Targets

HDAC1

Tclin

Histone deacetylase 1

12 Activities

Items per page:

1 – 10 of 12

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
EC50	7.39		17868033

Ki	9.07		20139990

Ki	9.07	Nat. Chem. Biol., (2010) 6:3:238	20139990

Ki	9.05	Bioorg. Med. Chem., (2015) 23:16:5151	25637120

IC50	8.86	Bioorg Med Chem, (2019) 27:8:1595	30879863

IC50	7.82	Bioorg. Med. Chem. Lett., (2011) 21:16:4909	21742496

IC50	7.75	Bioorg. Med. Chem. Lett., (2008) 18:6:1814	18308563

IC50	7.7	Eur J Med Chem, (2017) 134:None:13	28395150

Ki	7.58	J. Med. Chem., (2011) 54:13:4694	21634430

IC50	7.47	Eur J Med Chem, (2018) 150:None:282	29533873

HDAC6

Tclin

Histone deacetylase 6

10 Activities

Items per page:

1 – 10 of 10

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	8.8		20139990

EC50	7.09		17868033

Ki	8.8	Nat. Chem. Biol., (2010) 6:3:238	20139990

Ki	8.8	Bioorg. Med. Chem., (2015) 23:16:5151	25637120

IC50	8.01	Eur J Med Chem, (2017) 134:None:13	28395150

Ki	8	J. Med. Chem., (2011) 54:13:4694	21634430

IC50	7.82	Bioorg. Med. Chem. Lett., (2008) 18:6:1814	18308563

IC50	7.57	Eur J Med Chem, (2018) 150:None:282	29533873

IC50	7.3	Eur J Med Chem, (2016) 122:None:92	27344487

IC50	7.09	J Med Chem, (2020) 63:1:23	31415174

HDAC8

Tclin

Histone deacetylase 8

9 Activities

Items per page:

1 – 9 of 9

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
EC50	6.67		17868033

Ki	7.6		20139990

Ki	7.66	J. Med. Chem., (2011) 54:13:4694	21634430

Ki	7.6	Nat. Chem. Biol., (2010) 6:3:238	20139990

Ki	7.6	Bioorg. Med. Chem., (2015) 23:16:5151	25637120

IC50	7.17	Bioorg Med Chem, (2019) 27:8:1595	30879863

IC50	7.16	Eur J Med Chem, (2017) 134:None:13	28395150

IC50	6.7	Eur J Med Chem, (2016) 122:None:92	27344487

IC50	6.45	Eur J Med Chem, (2018) 150:None:282	29533873

HDAC2

Tclin

Histone deacetylase 2

7 Activities

Items per page:

1 – 7 of 7

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	9.07		20139990

EC50	6.9		17868033

Ki	9.07	Nat. Chem. Biol., (2010) 6:3:238	20139990

Ki	9.05	Bioorg. Med. Chem., (2015) 23:16:5151	25637120

Ki	7.66	J. Med. Chem., (2011) 54:13:4694	21634430

IC50	7.31	Eur J Med Chem, (2016) 122:None:92	27344487

IC50	7.3	Eur J Med Chem, (2017) 134:None:13	28395150

HDAC3

Tclin

Histone deacetylase 3

7 Activities

Items per page:

1 – 7 of 7

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
EC50	7.52		17868033

Ki	8.82		20139990

Ki	8.82	Nat. Chem. Biol., (2010) 6:3:238	20139990

Ki	8.82	Bioorg. Med. Chem., (2015) 23:16:5151	25637120

IC50	8.14	ACS Med Chem Lett, (2021) 12:4.0:540	33854701

Ki	7.72	J. Med. Chem., (2011) 54:13:4694	21634430

IC50	7.34	Bioorg. Med. Chem. Lett., (2008) 18:6:1814	18308563

HDAC4

Tclin

Histone deacetylase 4

6 Activities

Items per page:

1 – 6 of 6

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	6.42		20139990

EC50	6.94		17868033

Ki	7.82	J. Med. Chem., (2011) 54:13:4694	21634430

IC50	7.62	Bioorg. Med. Chem. Lett., (2008) 18:6:1814	18308563

Ki	6.42	Nat. Chem. Biol., (2010) 6:3:238	20139990

Ki	6.42	Bioorg. Med. Chem., (2015) 23:16:5151	25637120

HDAC7

Tclin

Histone deacetylase 7

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
EC50	7.17		17868033

Ki	7.12		20139990

Ki	7.29	J. Med. Chem., (2011) 54:13:4694	21634430

Ki	7.12	Nat. Chem. Biol., (2010) 6:3:238	20139990

Ki	7.12	Bioorg. Med. Chem., (2015) 23:16:5151	25637120

HDAC9

Tclin

Histone deacetylase 9

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
EC50	6.89		17868033

Ki	6.6		20139990

Ki	7.62	J. Med. Chem., (2011) 54:13:4694	21634430

Ki	6.6	Nat. Chem. Biol., (2010) 6:3:238	20139990

Ki	6.6	Bioorg. Med. Chem., (2015) 23:16:5151	25637120

HDAC5

Tclin

Histone deacetylase 5

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	6.76		20139990

Ki	7.6	J. Med. Chem., (2011) 54:13:4694	21634430

Ki	6.76	Nat. Chem. Biol., (2010) 6:3:238	20139990

Ki	6.76	Bioorg. Med. Chem., (2015) 23:16:5151	25637120

HDAC11

Tclin

Histone deacetylase 11

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.57		J. Med. Chem., (2011) 54:13:4694	21634430

HDAC10

Tclin

Histone deacetylase 10

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.23		J. Med. Chem., (2011) 54:13:4694	21634430

BRD4

Tchem

Bromodomain-containing protein 4

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	7.57		Bioorg Med Chem Lett, (2017) 27:17:4051	28765013