CHEMBL1688861,CHEMBL3764895
Ligand Summary
Name: 3-(1-Amino-1-methylethyl)-N-{(2R)-7-[(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl}-5-(trifluoromethyl)benzamide
PubChem: 50992247
PubChem: 90488999
ChEMBL: CHEMBL1688861
ChEMBL: CHEMBL3764895
LyCHI: 9TADUHHX9LZK
Target Activities
BRAF
Serine/threonine-protein kinase B-raf
4 Activities
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1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.68 | J. Med. Chem., (2011) 54:6:1836 | ||||
IC50 | 8.68 | J. Med. Chem., (2011) 54:6:1836 | ||||
IC50 | 8.68 | Bioorg. Med. Chem. Lett., (2016) 26:4:1156 | ||||
IC50 | 8.38 | J. Med. Chem., (2011) 54:6:1836 | ||||
RAF1
RAF proto-oncogene serine/threonine-protein kinase
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.6 | J. Med. Chem., (2011) 54:6:1836 | ||||
KCNH2
Potassium voltage-gated channel subfamily H member 2
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 5.13 | Bioorg. Med. Chem. Lett., (2016) 26:4:1156 | ||||
KDR
Vascular endothelial growth factor receptor 2
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.21 | J. Med. Chem., (2011) 54:6:1836 | ||||
EPHA2
Ephrin type-A receptor 2
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.96 | J. Med. Chem., (2011) 54:6:1836 | ||||
DDR2
Discoidin domain-containing receptor 2
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.15 | J. Med. Chem., (2011) 54:6:1836 | ||||
RET
Proto-oncogene tyrosine-protein kinase receptor Ret
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 9.1 | J. Med. Chem., (2011) 54:6:1836 | ||||