Pharos : Ligand Details - 9HMDC3VW2Z3N

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Ligand Summary

Ligand Structure

Rendered image for the query structure

Synonyms & Links

Name: GDC-0994

PubChem: 71727581

ChEMBL: CHEMBL3544964

LyCHI: 9HMDC3VW2Z3N

Target Activities

Explore Associated and Predicted Targets

MAPK1

Tchem

Mitogen-activated protein kinase 1

7 Activities

Items per page:

1 – 7 of 7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	9.52		Bioorg. Med. Chem. Lett., (2015) 25:19:4047	26298497

Kd	8.8		J Med Chem, (2019) 62:24:11004	31710489

Kd	8.8		J Med Chem, (2019) 62:24:11004	31710489

IC50	8.51		J Med Chem, (2016) 59:12:5650	27227380

IC50	8.48		None, (2014) None:None:None

IC50	8.48		None, (2016) None:None:None

Kd	7.66		Science, (2017) 358:6367:None	29191878

MAPK3

Tchem

Mitogen-activated protein kinase 3

3 Activities

Items per page:

1 – 3 of 3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	8.92		Bioorg. Med. Chem. Lett., (2015) 25:19:4047	26298497

IC50	8.21		J Med Chem, (2016) 59:12:5650	27227380

Kd	7.72		Science, (2017) 358:6367:None	29191878

Q6ZSR9

Tchem

Uncharacterized protein FLJ45252

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Kd	6.33		Science, (2017) 358:6367:None	29191878