CHEMBL72511
Ligand Summary
Name: N*4*-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-N*1*-hydroxy-2-hydroxymethyl-3-(4-methoxy-phenyl)-succinamide
PubChem: 9886977
ChEMBL: CHEMBL72511
LyCHI: 8H14WVJH5GJZ
Target Activities
ADAM17
Disintegrin and metalloproteinase domain-containing protein 17
4 Activities
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1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 9.22 | J. Med. Chem., (2002) 45:11:2289 | ||||
Ki | 9.22 | Bioorg. Med. Chem. Lett., (2006) 16:10:2632 | ||||
IC50 | 7.32 | Bioorg. Med. Chem. Lett., (2006) 16:10:2632 | ||||
IC50 | 7.25 | Bioorg. Med. Chem., (2009) 17:2:444 | ||||
MMP3
Stromelysin-1
2 Activities
MMP1
Interstitial collagenase
2 Activities
TNF
Tumor necrosis factor
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.32 | J. Med. Chem., (2002) 45:11:2289 | ||||
MMP2
72 kDa type IV collagenase
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 9.3 | J. Med. Chem., (2002) 45:11:2289 | ||||
MMP13
Collagenase 3
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 9.3 | Bioorg. Med. Chem. Lett., (2006) 16:10:2632 | ||||