epigallocatechin gallate
Ligand Summary
Name: epigallocatechin gallate
PubChem: 65064
Guide to Pharmacology: 7002
ChEMBL: CHEMBL297453
LyCHI: 8G955XN2LS69
Target Activities
TERT
Telomerase reverse transcriptase
2 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6 | J. Med. Chem., (2012) 55:8:3678 | ||||
IC50 | 6 | MedChemComm, (2011) 2:4:229 | ||||
ABCB1
Multidrug resistance protein 1
2 Activities
PSMB5
Proteasome subunit beta type-5
2 Activities
BCL2
Apoptosis regulator Bcl-2
2 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 6.63 | Proc. Natl. Acad. Sci. U.S.A., (2007) 104:49:19512 | ||||
Ki | 6.47 | Med Chem Res, (2010) 19:8:817 | ||||
RAD52
DNA repair protein RAD52 homolog
2 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.56 | None, None:None:None | ||||
IC50 | 6.56 | |||||
EP300
Histone acetyltransferase p300
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 4.52 | |||||
KAT2B
Histone acetyltransferase KAT2B
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 4.22 | |||||
APP
Amyloid-beta A4 protein
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.3 | J. Nat. Prod., (2015) 78:6:1221 | ||||
DNMT1
DNA (cytosine-5)-methyltransferase 1
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.3 | J. Med. Chem., (2015) 58:6:2569 | ||||
TTR
Transthyretin
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 6.4 | J Med Chem, (2017) 60:13:5749 | ||||
PGD
6-phosphogluconate dehydrogenase, decarboxylating
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.14 | Bioorg. Med. Chem., (2008) 16:7:3580 | ||||
BACE1
Beta-secretase 1
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 6.12 | Bioorg. Med. Chem. Lett., (2012) 22:3:1408 | ||||
STAT1
Signal transducer and activator of transcription 1-alpha/beta
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 6.16 | J. Nat. Prod., (2014) 77:3:543 | ||||
PGAM1
Phosphoglycerate mutase 1
1 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | 6.31 | Bioorg Med Chem, (2018) 26:8:1961 | ||||